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Database: UniProt/TrEMBL
Entry: Q8Z1U8_SALTI
LinkDB: Q8Z1U8_SALTI
Original site: Q8Z1U8_SALTI 
ID   Q8Z1U8_SALTI            Unreviewed;       449 AA.
AC   Q8Z1U8; A0A0B4NQY2; A0A0C9E9H6; Q7C5P6;
DT   01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2002, sequence version 1.
DT   20-JAN-2016, entry version 106.
DE   RecName: Full=Aspartokinase {ECO:0000256|RuleBase:RU003448};
DE            EC=2.7.2.4 {ECO:0000256|RuleBase:RU003448};
GN   Name=lysC {ECO:0000313|EMBL:AAO71590.1};
GN   OrderedLocusNames=STY4416 {ECO:0000313|EMBL:CAD09204.1}, t4126
GN   {ECO:0000313|EMBL:AAO71590.1};
GN   ORFNames=ACT03_16375 {ECO:0000313|EMBL:ALG18662.1}, ACT04_22985
GN   {ECO:0000313|EMBL:ALG24236.1}, ERS083263_01428
GN   {ECO:0000313|EMBL:CET15765.1}, ERS325172_04035
GN   {ECO:0000313|EMBL:CER24978.1}, ERS325188_03969
GN   {ECO:0000313|EMBL:CQV78927.1}, ERS325190_01798
GN   {ECO:0000313|EMBL:CQX34106.1}, ERS325196_04060
GN   {ECO:0000313|EMBL:CQT85361.1}, ERS325215_03956
GN   {ECO:0000313|EMBL:CRB72118.1}, ERS325223_03955
GN   {ECO:0000313|EMBL:CQT77183.1}, ERS325225_03940
GN   {ECO:0000313|EMBL:CQT73479.1}, ERS325232_04142
GN   {ECO:0000313|EMBL:CQT85783.1}, ERS325296_03864
GN   {ECO:0000313|EMBL:CQW06606.1}, ERS325302_03606
GN   {ECO:0000313|EMBL:CQT57360.1}, ERS325320_03984
GN   {ECO:0000313|EMBL:CQT79937.1}, ERS325374_01823
GN   {ECO:0000313|EMBL:CQS78104.1}, ERS325389_04050
GN   {ECO:0000313|EMBL:CQT79243.1}, ERS325400_01679
GN   {ECO:0000313|EMBL:CQS66370.1}, ERS325434_01665
GN   {ECO:0000313|EMBL:CQW78131.1}, ERS325436_03924
GN   {ECO:0000313|EMBL:CQX85264.1}, ERS325437_01531
GN   {ECO:0000313|EMBL:CQW76396.1}, ERS325458_01506
GN   {ECO:0000313|EMBL:CQS61128.1}, ERS326267_04052
GN   {ECO:0000313|EMBL:CES39803.1}, ERS326384_04083
GN   {ECO:0000313|EMBL:CES23770.1}, ERS326389_01710
GN   {ECO:0000313|EMBL:CES18574.1}, ERS326420_01530
GN   {ECO:0000313|EMBL:CER50441.1}, ERS326462_01668
GN   {ECO:0000313|EMBL:CES86648.1}, ERS326499_01874
GN   {ECO:0000313|EMBL:CRC46969.1}, ERS327392_04089
GN   {ECO:0000313|EMBL:CER76063.1};
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370 {ECO:0000313|Proteomes:UP000000541};
RN   [1] {ECO:0000313|EMBL:CAD09204.1, ECO:0000313|Proteomes:UP000000541}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18 {ECO:0000313|EMBL:CAD09204.1,
RC   ECO:0000313|Proteomes:UP000000541};
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P.,
RA   Cronin A., Davis P., Davies R.M., Dowd L., White N., Farrar J.,
RA   Feltwell T., Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K.,
RA   Krogh A., Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C.,
RA   Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K.,
RA   Whitehead S., Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella
RT   enterica serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [2] {ECO:0000313|EMBL:AAO71590.1, ECO:0000313|Proteomes:UP000002670}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2 {ECO:0000313|Proteomes:UP000002670}, and Ty2
RC   {ECO:0000313|EMBL:AAO71590.1};
RX   PubMed=12644504; DOI=10.1128/JB.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J.,
RA   Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2
RT   and CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
RN   [3] {ECO:0000313|EMBL:CER24978.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=A59307 {ECO:0000313|EMBL:CER76063.1}, Dn136
RC   {ECO:0000313|EMBL:CQT85361.1}, Dn160 {ECO:0000313|EMBL:CQT73479.1},
RC   Dn189 {ECO:0000313|EMBL:CQT85783.1}, Dn45
RC   {ECO:0000313|EMBL:CQV78927.1}, Dtc103 {ECO:0000313|EMBL:CQT77183.1},
RC   Dtc81 {ECO:0000313|EMBL:CQX34106.1}, Dtc98
RC   {ECO:0000313|EMBL:CRB72118.1}, IB5341 {ECO:0000313|EMBL:CET15765.1},
RC   Ipt57 {ECO:0000313|EMBL:CQT57360.1}, MDUST167
RC   {ECO:0000313|EMBL:CES39803.1}, MDUST284 {ECO:0000313|EMBL:CES23770.1},
RC   MDUST289 {ECO:0000313|EMBL:CES18574.1}, MDUST320
RC   {ECO:0000313|EMBL:CER50441.1}, MDUST362 {ECO:0000313|EMBL:CES86648.1},
RC   MDUST399 {ECO:0000313|EMBL:CRC46969.1}, Np93
RC   {ECO:0000313|EMBL:CER24978.1}, Ty1-16 {ECO:0000313|EMBL:CQS66370.1},
RC   Ty2-101 {ECO:0000313|EMBL:CQX85264.1}, Ty2-107
RC   {ECO:0000313|EMBL:CQT79243.1}, Ty2-115 {ECO:0000313|EMBL:CQW76396.1},
RC   Ty2-120 {ECO:0000313|EMBL:CQS78104.1}, Ty2-170
RC   {ECO:0000313|EMBL:CQW06606.1}, Ty2-71 {ECO:0000313|EMBL:CQW78131.1},
RC   Ty2-75 {ECO:0000313|EMBL:CQS61128.1}, and Ty3-193
RC   {ECO:0000313|EMBL:CQT79937.1};
RA   Informatics Pathogen;
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:ALG24236.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=B/SF/13/03/195 {ECO:0000313|EMBL:ALG24236.1};
RA   Muhamad Harish S., Sim K.S., Mohd Nor F., Mat Hussin H., Hamzah W.M.,
RA   Mohd Najimuddin M.N., Ismail A.;
RT   "Complete Genome Sequence of Salmonella enterica sibsp. enterica
RT   serovar Typhi Isolate B/SF/13/03/195 Associated with a Typhoid Carrier
RT   in Pasir Mas, Kelantan, Malaysia.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:ALG18662.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PM016/13 {ECO:0000313|EMBL:ALG18662.1};
RA   Ismail A., Muhamad Harish S., Sim K.S., Mohd Najimuddin M.N.;
RT   "Genome Sequence of Salmonella enterica subsp. enterica serovar Typhi
RT   Isolate PM016/13 from Well Water Associated with a Typhoid Outbreak in
RT   Pasir Mas, Kelantan, Malaysia.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: ATP + L-aspartate = ADP + 4-phospho-L-
CC       aspartate. {ECO:0000256|RuleBase:RU003448}.
CC   -!- SIMILARITY: Belongs to the aspartokinase family.
CC       {ECO:0000256|RuleBase:RU003448}.
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DR   EMBL; AE014613; AAO71590.1; -; Genomic_DNA.
DR   EMBL; CP012091; ALG18662.1; -; Genomic_DNA.
DR   EMBL; CP012151; ALG24236.1; -; Genomic_DNA.
DR   EMBL; AL513382; CAD09204.1; -; Genomic_DNA.
DR   EMBL; CEXJ01000022; CER24978.1; -; Genomic_DNA.
DR   EMBL; CEXP01000006; CER50441.1; -; Genomic_DNA.
DR   EMBL; CEXU01000023; CER76063.1; -; Genomic_DNA.
DR   EMBL; CEYF01000006; CES18574.1; -; Genomic_DNA.
DR   EMBL; CEYE01000023; CES23770.1; -; Genomic_DNA.
DR   EMBL; CEYH01000023; CES39803.1; -; Genomic_DNA.
DR   EMBL; CEYU01000006; CES86648.1; -; Genomic_DNA.
DR   EMBL; CEZA01000005; CET15765.1; -; Genomic_DNA.
DR   EMBL; CUZM01000006; CQS61128.1; -; Genomic_DNA.
DR   EMBL; CUYO01000006; CQS66370.1; -; Genomic_DNA.
DR   EMBL; CUYZ01000006; CQS78104.1; -; Genomic_DNA.
DR   EMBL; CUYQ01000019; CQT57360.1; -; Genomic_DNA.
DR   EMBL; CUYJ01000023; CQT73479.1; -; Genomic_DNA.
DR   EMBL; CUZV01000021; CQT77183.1; -; Genomic_DNA.
DR   EMBL; CUZH01000023; CQT79243.1; -; Genomic_DNA.
DR   EMBL; CUZW01000022; CQT79937.1; -; Genomic_DNA.
DR   EMBL; CUYV01000024; CQT85361.1; -; Genomic_DNA.
DR   EMBL; CUYW01000023; CQT85783.1; -; Genomic_DNA.
DR   EMBL; CVAI01000021; CQV78927.1; -; Genomic_DNA.
DR   EMBL; CVBK01000021; CQW06606.1; -; Genomic_DNA.
DR   EMBL; CVCL01000006; CQW76396.1; -; Genomic_DNA.
DR   EMBL; CVCJ01000006; CQW78131.1; -; Genomic_DNA.
DR   EMBL; CVCV01000006; CQX34106.1; -; Genomic_DNA.
DR   EMBL; CVCK01000021; CQX85264.1; -; Genomic_DNA.
DR   EMBL; CVFY01000022; CRB72118.1; -; Genomic_DNA.
DR   EMBL; CVGS01000006; CRC46969.1; -; Genomic_DNA.
DR   RefSeq; NP_458518.1; NC_003198.1.
DR   RefSeq; WP_000136394.1; NZ_CXZB01000006.1.
DR   STRING; 220341.STY4416; -.
DR   EnsemblBacteria; CAD09204; CAD09204; CAD09204.
DR   EnsemblBacteria; CEP54868; CEP54868; ERS325052_04058.
DR   EnsemblBacteria; CEQ58720; CEQ58720; ERS326331_01841.
DR   EnsemblBacteria; CER12516; CER12516; ERS248971_01697.
DR   EnsemblBacteria; CER18189; CER18189; ERS326259_01662.
DR   EnsemblBacteria; CER24978; CER24978; ERS325172_04035.
DR   EnsemblBacteria; CER32424; CER32424; ERS326407_03994.
DR   EnsemblBacteria; CER45931; CER45931; ERS326268_01842.
DR   EnsemblBacteria; CER50441; CER50441; ERS326420_01530.
DR   EnsemblBacteria; CER61198; CER61198; ERS325165_03944.
DR   EnsemblBacteria; CER62277; CER62277; ERS326373_01698.
DR   EnsemblBacteria; CER62924; CER62924; ERS326475_01840.
DR   EnsemblBacteria; CER68788; CER68788; ERS325101_03979.
DR   EnsemblBacteria; CES10017; CES10017; ERS326256_01846.
DR   EnsemblBacteria; CES14698; CES14698; ERS326249_04030.
DR   EnsemblBacteria; CES18574; CES18574; ERS326389_01710.
DR   EnsemblBacteria; CES23770; CES23770; ERS326384_04083.
DR   EnsemblBacteria; CES39803; CES39803; ERS326267_04052.
DR   EnsemblBacteria; CES86648; CES86648; ERS326462_01668.
DR   EnsemblBacteria; CET15765; CET15765; ERS083263_01428.
DR   EnsemblBacteria; CET17277; CET17277; ERS326456_03970.
DR   EnsemblBacteria; CET24312; CET24312; ERS326469_01591.
DR   EnsemblBacteria; CET75761; CET75761; ERS326314_01843.
DR   EnsemblBacteria; CET87224; CET87224; ERS326275_01659.
DR   EnsemblBacteria; CEU05109; CEU05109; ERS326422_01821.
DR   EnsemblBacteria; CEU05706; CEU05706; ERS326412_04060.
DR   GeneID; 1250633; -.
DR   KEGG; stt:t4126; -.
DR   KEGG; sty:STY4416; -.
DR   PATRIC; 18547073; VBISalEnt120419_4516.
DR   eggNOG; COG0527; LUCA.
DR   eggNOG; ENOG4105CFH; Bacteria.
DR   HOGENOM; HOG000293094; -.
DR   KO; K00928; -.
DR   OMA; MICFGAN; -.
DR   OrthoDB; EOG6M0T34; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR   GO; GO:0004072; F:aspartate kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009089; P:lysine biosynthetic process via diaminopimelate; IEA:InterPro.
DR   Gene3D; 3.40.1160.10; -; 2.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR   InterPro; IPR005260; Asp_kin_monofn.
DR   InterPro; IPR001341; Asp_kinase_dom.
DR   InterPro; IPR018042; Aspartate_kinase_CS.
DR   Pfam; PF00696; AA_kinase; 1.
DR   Pfam; PF01842; ACT; 1.
DR   PIRSF; PIRSF000726; Asp_kin; 1.
DR   SUPFAM; SSF53633; SSF53633; 1.
DR   TIGRFAMs; TIGR00656; asp_kin_monofn; 1.
DR   TIGRFAMs; TIGR00657; asp_kinases; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS00324; ASPARTOKINASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000541,
KW   ECO:0000313|Proteomes:UP000002670};
KW   Kinase {ECO:0000256|RuleBase:RU003448, ECO:0000313|EMBL:CAD09204.1};
KW   Transferase {ECO:0000256|RuleBase:RU003416,
KW   ECO:0000313|EMBL:CAD09204.1}.
FT   DOMAIN      313    394       ACT. {ECO:0000259|PROSITE:PS51671}.
SQ   SEQUENCE   449 AA;  48595 MW;  2B485698881A09A8 CRC64;
     MTEIVVSKFG GTSVADFDAM NRSADIVLSD ANVRLVVLSA SAGITNLLVA LAEGMEPGER
     FATLDAIRKI QFDILDRLRH PNVIREEIER LLENITILAE AASLATSAAL TDELVSHGEL
     MSTLLFVEIL RERDVQAHWF DVRKVMRTSD RFGRAEPDVA ALAELAAQQL LPRLSETLVI
     TQGFIGSESK GRTTTLGRGG SDYTAALLAE ALHAARVDIW TDVPGIYTTD PRVVPVAQRI
     DEIDFEEAAE MATFGAKVLH PATLLPAVRS DIPVFVGSSK DPQAGGTLVC NKTQNPPLFR
     ALALRRNQTL LTLHSLNMLH SRGFLAEVFG ILARHNISVD LITTSEVSVA LTLDTTGSTS
     TGDTLLTQSL LMELSALCRV EVEEGLALVA LIGNNLSKAC GVGKEVFGVL EPFNIRMICY
     GASSHNLCFL VPGDDAEKVV QKLHQNLFE
//
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