ID Q8ZL87_SALTY Unreviewed; 675 AA.
AC Q8ZL87;
DT 01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2002, sequence version 1.
DT 24-JAN-2024, entry version 109.
DE SubName: Full=Alpha-amylase {ECO:0000313|EMBL:AAL22523.1};
DE EC=3.2.1.1 {ECO:0000313|EMBL:AAL22523.1};
GN Name=malS {ECO:0000313|EMBL:AAL22523.1};
GN OrderedLocusNames=STM3664 {ECO:0000313|EMBL:AAL22523.1};
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287 {ECO:0000313|EMBL:AAL22523.1, ECO:0000313|Proteomes:UP000001014};
RN [1] {ECO:0000313|EMBL:AAL22523.1, ECO:0000313|Proteomes:UP000001014}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720
RC {ECO:0000313|Proteomes:UP000001014};
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|PIRSR:PIRSR036917-2};
CC Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR036917-2};
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DR EMBL; AE006468; AAL22523.1; -; Genomic_DNA.
DR RefSeq; NP_462564.1; NC_003197.2.
DR RefSeq; WP_000761305.1; NC_003197.2.
DR AlphaFoldDB; Q8ZL87; -.
DR STRING; 99287.STM3664; -.
DR CAZy; GH13; Glycoside Hydrolase Family 13.
DR PaxDb; 99287-STM3664; -.
DR GeneID; 1255188; -.
DR PATRIC; fig|99287.12.peg.3877; -.
DR HOGENOM; CLU_022115_1_0_6; -.
DR OMA; DKVMVVW; -.
DR PhylomeDB; Q8ZL87; -.
DR BioCyc; SENT99287:STM3664-MONOMER; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0042597; C:periplasmic space; IEA:InterPro.
DR GO; GO:0004556; F:alpha-amylase activity; IEA:UniProtKB-EC.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0030980; P:alpha-glucan catabolic process; IEA:InterPro.
DR GO; GO:0009313; P:oligosaccharide catabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.80; Glycosidases; 2.
DR InterPro; IPR014635; A_amylase_MalS.
DR InterPro; IPR006047; Glyco_hydro_13_cat_dom.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR10357; ALPHA-AMYLASE FAMILY MEMBER; 1.
DR PANTHER; PTHR10357:SF209; PERIPLASMIC ALPHA-AMYLASE; 1.
DR Pfam; PF00128; Alpha-amylase; 2.
DR PIRSF; PIRSF036917; Alph_amls_MalS; 1.
DR SMART; SM00642; Aamy; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|PIRSR:PIRSR036917-2};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR036917-4};
KW Glycosidase {ECO:0000313|EMBL:AAL22523.1};
KW Hydrolase {ECO:0000313|EMBL:AAL22523.1};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR036917-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000001014};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..675
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004318437"
FT DOMAIN 192..636
FT /note="Glycosyl hydrolase family 13 catalytic"
FT /evidence="ECO:0000259|SMART:SM00642"
FT ACT_SITE 459
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR036917-1"
FT ACT_SITE 502
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR036917-1"
FT BINDING 313
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR036917-2"
FT SITE 564
FT /note="Transition state stabilizer"
FT /evidence="ECO:0000256|PIRSR:PIRSR036917-3"
FT DISULFID 57..75
FT /evidence="ECO:0000256|PIRSR:PIRSR036917-4"
FT DISULFID 121..536
FT /evidence="ECO:0000256|PIRSR:PIRSR036917-4"
SQ SEQUENCE 675 AA; 75742 MW; 711E25C319D7EFB9 CRC64;
MKLAAFALTL IPGIAIASSW TSPGFPTFST QETGRFTSHA ALTKGTRALT LHIDQQCWQP
SGAIKLNQML SLKPCEGAPP QWRLFKDGDY TITVDTRSGT PTLLLSIKTE PERTAQLAYQ
CPVWDGSPLT LDVRQTFPEG TVVRDYYSGQ TDTVQNGQIT LQPADSHGLL LLERAETHAP
APFNWRNATV YFVLTDRFRN GDPTNDHSYS RHKDGMQEIG TFHGGDLRGL TSQLDYLQQL
GVNALWISSP FEQIHGWVGG GTKGDFPHYA YHGYYTQDWT TLDANMGSEA DLRALVDGAH
QRGIRILFDV VMNHAGYATL ADMQEYQFGA LYLSGAERQK ILGDRWTNWR PAAGQSWHSF
NDYINFSDSA AWEKWWGKKW IRTDIGDYDS PGFDDLTLSL AFLPDIKTES TTPSGLPAFY
ANKPDTKAKF IEGYTPRDYL THWLSQWVHD YGIDGFRVDT AKNVELPAWQ QLKTQASAAL
REWKQANPDK ALDNSPFWMT GEAWGHGVMK SDYYRYGFDA MINFDYQEQA AKAVDCLAEM
GPVWQQMTDK MQDFNVLSYL SSHDTRLFRE GGDKAAELLL LSPGAVQIFY GDESARPFGP
TGSDPLQGTR SDMNWQDVSG KSAAAVAHWQ RISQFRARHP AIGAGQQTTL TLKHGYGFVR
QYGDDTVMVV WAGRR
//