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Database: UniProt/TrEMBL
Entry: Q99ZX8_STRP1
LinkDB: Q99ZX8_STRP1
Original site: Q99ZX8_STRP1 
ID   Q99ZX8_STRP1            Unreviewed;       322 AA.
AC   Q99ZX8; Q48Z49;
DT   01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2001, sequence version 1.
DT   09-JUL-2014, entry version 83.
DE   SubName: Full=Putative acetoin dehydrogenase (TPP-dependent) alpha chain;
DE   SubName: Full=Pyruvate dehydrogenase E1 component alpha subunit;
DE            EC=1.2.4.1;
GN   Name=acoA; OrderedLocusNames=M5005_Spy0751, SPy_1026;
OS   Streptococcus pyogenes serotype M1.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=301447;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700294 / SF370 / Serotype M1, and SF370;
RX   PubMed=11296296; DOI=10.1073/pnas.071559398;
RA   Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K.,
RA   Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P.,
RA   Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J.,
RA   Yuan X., Clifton S.W., Roe B.A., McLaughlin R.E.;
RT   "Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-947 / MGAS5005 / Serotype M1, and MGAS5005;
RX   PubMed=16088826; DOI=10.1086/432514;
RA   Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K.,
RA   Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J.,
RA   Hoe N.P., Musser J.M.;
RT   "Evolutionary origin and emergence of a highly successful clone of
RT   serotype M1 group A Streptococcus involved multiple horizontal gene
RT   transfer events.";
RL   J. Infect. Dis. 192:771-782(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=MGAS5005;
RX   PubMed=24733896; DOI=10.1073/pnas.1403138111;
RA   Nasser W., Beres S.B., Olsen R.J., Dean M.A., Rice K.A., Long S.W.,
RA   Kristinsson K.G., Gottfredsson M., Vuopio J., Raisanen K., Cauget D.,
RA   Steinbakk M., Lowe D.E., McGeere A., Darenberg J.,
RA   Henriques-Normark B., van Benedeng C.A., Hoffmann S., Musser J.M.;
RT   "Evolutionary pathway to increased virulence and epidemic group A
RT   Streptococcus disease derived from 3,615 genome sequences.";
RL   Proc. Natl. Acad. Sci. U.S.A. 111:E1768-E1776(2014).
RN   [4]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SF370;
RA   Nasser W., Beres S.B., Olsen R.J., Dean M.A., Rice K.A., Long S.W.,
RA   Kristinsson K.G., Gottfredsson M., Vuopio J., Raisanen K., Cauget D.,
RA   Steinbakk M., Lowe D.E., McGeere A., Darenberg J.,
RA   Henriques-Normark B., van Benedeng C.A., Hoffmann S., Mussera J.M.;
RT   "Evolutionary pathway to increased virulence and epidemic group A
RT   Streptococcus disease derived from 3,615 genome sequences.";
RL   Proc. Natl. Acad. Sci. U.S.A. 0:0-0(2014).
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DR   EMBL; AE004092; AAK33920.1; -; Genomic_DNA.
DR   EMBL; CP000017; AAZ51369.1; -; Genomic_DNA.
DR   RefSeq; NP_269199.1; NC_002737.1.
DR   RefSeq; YP_282114.1; NC_007297.1.
DR   EnsemblBacteria; AAK33920; AAK33920; SPy_1026.
DR   EnsemblBacteria; AAZ51369; AAZ51369; M5005_Spy0751.
DR   GeneID; 3572155; -.
DR   GeneID; 901160; -.
DR   KEGG; spy:SPy_1026; -.
DR   KEGG; spz:M5005_Spy_0751; -.
DR   PATRIC; 19715639; VBIStrPyo79812_0884.
DR   HOGENOM; HOG000281336; -.
DR   KO; K00161; -.
DR   OMA; RERTCHA; -.
DR   OrthoDB; EOG6JMMWC; -.
DR   BioCyc; SPYO160490:GJ81-847-MONOMER; -.
DR   BioCyc; SPYO293653:GHFC-810-MONOMER; -.
DR   GO; GO:0004739; F:pyruvate dehydrogenase (acetyl-transferring) activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.970; -; 1.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR029061; THDP-binding.
DR   Pfam; PF00676; E1_dh; 1.
DR   SUPFAM; SSF52518; SSF52518; 1.
PE   4: Predicted;
KW   Complete proteome; Oxidoreductase; Pyruvate.
SQ   SEQUENCE   322 AA;  35445 MW;  E884B46D80CE0EBF CRC64;
     MVTVSKEQHL DMFLKMERIR EFDSRINKLV RRGFVQGMTH FSVGEEAANV GAVAHLSYDD
     IIFSNHRGHG QSIAKDMDLN KMMAELAGKA TGVSKGRGGS MHLADFEKGN YGTNGIVGGG
     YALAVGAALT QQYKGTNNIA VAFSGDGATN EGSFHESVNM AATWKLPVIF FIINNRYGIS
     MSINNATNTP HLYTRAEAYG VPGFYCEDGN DVMAVYETMG KAVEHVRGGN GPAIVEVESY
     RWFGHSTADA GKYRTKEEVD EWKEKDPMIK YRTYLTSEGI ATDDELDAIQ AQVKKEVDDA
     YEFAQNSPDP ELSVAFEDVW VD
//
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