ID   Q9DGH5_DANRE            Unreviewed;       319 AA.
AC   Q9DGH5;
DT   01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2001, sequence version 1.
DT   03-APR-2013, entry version 77.
DE   SubName: Full=Thymidylate synthase;
GN   Name=tyms;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RA   Gill R.L.Jr., Warren J.T.Jr.;
RT   "Molecular Genetic Analysis of Folate Metabolism in the Zebrafish.";
RL   Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: 5,10-methylenetetrahydrofolate + dUMP =
CC       dihydrofolate + dTMP.
CC   -!- PATHWAY: Pyrimidine metabolism; dTTP biosynthesis.
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DR   EMBL; AY005804; AAF97476.1; -; mRNA.
DR   IPI; IPI00510414; -.
DR   RefSeq; NP_571835.1; NM_131760.1.
DR   UniGene; Dr.1047; -.
DR   HSSP; P04818; 1HW4.
DR   ProteinModelPortal; Q9DGH5; -.
DR   SMR; Q9DGH5; 36-319.
DR   GeneID; 81540; -.
DR   KEGG; dre:81540; -.
DR   CTD; 7298; -.
DR   ZFIN; ZDB-GENE-040426-59; tyms.
DR   HOVERGEN; HBG001934; -.
DR   InParanoid; Q9DGH5; -.
DR   KO; K00560; -.
DR   UniPathway; UPA00575; -.
DR   NextBio; 20934154; -.
DR   GO; GO:0004799; F:thymidylate synthase activity; IDA:ZFIN.
DR   GO; GO:0006231; P:dTMP biosynthetic process; IDA:ZFIN.
DR   GO; GO:0006235; P:dTTP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0060041; P:retina development in camera-type eye; IMP:ZFIN.
DR   Gene3D; 3.30.572.10; -; 1.
DR   HAMAP; MF_00008; Thymidy_synth_bact; 1; -.
DR   InterPro; IPR023451; Thymidate_synth/dCMP_Mease.
DR   InterPro; IPR000398; Thymidylate_synthase.
DR   InterPro; IPR020940; Thymidylate_synthase_AS.
DR   Pfam; PF00303; Thymidylat_synt; 1.
DR   PRINTS; PR00108; THYMDSNTHASE.
DR   SUPFAM; SSF55831; Thymidylat_synth_C; 1.
DR   TIGRFAMs; TIGR03284; thym_sym; 1.
DR   PROSITE; PS00091; THYMIDYLATE_SYNTHASE; 1.
PE   2: Evidence at transcript level;
KW   Methyltransferase; Nucleotide biosynthesis; Transferase.
SQ   SEQUENCE   319 AA;  36313 MW;  E08B155B09DE1E84 CRC64;
     MPDTAVEVTN GHCVNGESKK EETNGGKKEF SLFCDERGYL SLVEFILQNG AKKGDRTGTG
     VISVFGTQAR YSLRDQFPLL TTKRVFWKGI LEELLWFIKG STNAKDLSEK GVRIWDANGS
     REFLDKNGFT DREEGDLGPV YGFQWRHFGA EYKDMHTDYS GEGVDQLQKV IDTIKSNPED
     RRIIMCAWNP KDLPLMALPP CHALCQFYVS NGELSCQLYQ RSGDIGLGVP FNIASYALLT
     YMIAHITGLK PGDFVHTLGD AHIYTNHIEP LKEQIQREPR PFPKLRIKRK VEQINDFCAE
     DFEIYDYDPH PTIKMQMAV
//