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Database: UniProt/TrEMBL
Entry: Q9I0L4_PSEAE
LinkDB: Q9I0L4_PSEAE
Original site: Q9I0L4_PSEAE 
ID   Q9I0L4_PSEAE            Unreviewed;       741 AA.
AC   Q9I0L4;
DT   01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2001, sequence version 1.
DT   22-NOV-2017, entry version 97.
DE   SubName: Full=Isocitrate dehydrogenase {ECO:0000313|EMBL:AAG06012.1};
GN   Name=idh {ECO:0000313|EMBL:AAG06012.1};
GN   OrderedLocusNames=PA2624 {ECO:0000313|EMBL:AAG06012.1};
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 /
OS   JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964 {ECO:0000313|EMBL:AAG06012.1, ECO:0000313|Proteomes:UP000002438};
RN   [1] {ECO:0000313|EMBL:AAG06012.1, ECO:0000313|Proteomes:UP000002438}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 /
RC   1C / PRS 101 / PAO1 {ECO:0000313|Proteomes:UP000002438};
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.Q., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.,
RA   Smith K., Spencer D., Wong G.K., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H., Hancock R.E., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an
RT   opportunistic pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; AE004091; AAG06012.1; -; Genomic_DNA.
DR   PIR; A83317; A83317.
DR   RefSeq; NP_251314.1; NC_002516.2.
DR   RefSeq; WP_003113369.1; NC_002516.2.
DR   ProteinModelPortal; Q9I0L4; -.
DR   SMR; Q9I0L4; -.
DR   STRING; 208964.PA2624; -.
DR   PaxDb; Q9I0L4; -.
DR   PRIDE; Q9I0L4; -.
DR   EnsemblBacteria; AAG06012; AAG06012; PA2624.
DR   GeneID; 882330; -.
DR   KEGG; pae:PA2624; -.
DR   PATRIC; fig|208964.12.peg.2746; -.
DR   PseudoCAP; PA2624; -.
DR   eggNOG; ENOG4105E9K; Bacteria.
DR   eggNOG; COG2838; LUCA.
DR   HOGENOM; HOG000240860; -.
DR   InParanoid; Q9I0L4; -.
DR   KO; K00031; -.
DR   OMA; RDSGKMW; -.
DR   PhylomeDB; Q9I0L4; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   PANTHER; PTHR36999; PTHR36999; 1.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002438};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002438}.
FT   REGION      133    140       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       350    350       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       548    548       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       552    552       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     146    146       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     547    547       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        255    255       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        420    420       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   741 AA;  81634 MW;  AA77F0720EADC1B5 CRC64;
     MSIRSKITYT FTDEAPALAT YSLLPIVKAF AASAGIDVET SDISLAGRIL ANFADRLEAD
     QRIEDDLARL AVLATSPDAN IIKLPNISAS VPQLKGAIAE LQGLGYKVPD FPEDPQTDEE
     KEVRARYAKI LGSAVNPVLR EGNSDRRAPA AVKAYARKHP HSMGKWSMAS RSHADYMRGG
     DFFSSEQSIT MAKAGDVRIE FVGKDGKVEV KKQLSLQEGE VLDSMFMSCG KLRDFFEKTL
     QDCKETGVMW SLHVKATMMK ISHPIVFGHA VSVYYKDVFD KWGQLFEELG VNPNNGISSV
     YDKIKSLPAS QQEEILHDIH EVYSHRPEMA MVDSVKGITN LHIPSDVIVD ASMPAMIRNS
     GQMWGKDGKQ KDTKAVMPES TYARIYQEMI NFCKTNGAFD PTTMGSVPNV GLMAQKAEEY
     GSHDKTFEMT ADGTMRVVLA DGSVLMQHKV ETGDIWRACQ TKDAPIRDWV KLAVTRARQS
     DTPAIFWLDP ERAHDRELRK KVELYLKDHD LTGLDISIMG YNEAIRVSME RLIRGKDTIS
     VTGNVLRDYL TDLFPIMELG TSAKMLSIVP LMAGGGMYET GAGGSAPKHV QQLVEENYLR
     WDSLGEFLAL AVSLEETGIK TGNAKAKLLG KALDEATGKL LDNNKSPSRK VGDIDNRGSH
     FYLAMYWAQA LAAQNEDAEL KAHFAPLAKA LTEQEATIVA ELNAVQGKPA EIGGYYRSNP
     ELTSKVMRPS ATFNAAIDSL A
//
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