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Database: UniProt/TrEMBL
Entry: Q9KZF3_STRCO
LinkDB: Q9KZF3_STRCO
Original site: Q9KZF3_STRCO 
ID   Q9KZF3_STRCO            Unreviewed;       739 AA.
AC   Q9KZF3;
DT   01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2000, sequence version 1.
DT   07-JUN-2017, entry version 95.
DE   SubName: Full=Isocitrate dehydrogenase {ECO:0000313|EMBL:CAB88977.1};
GN   OrderedLocusNames=SCO7000 {ECO:0000313|EMBL:CAB88977.1};
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226 {ECO:0000313|Proteomes:UP000001973};
RN   [1] {ECO:0000313|EMBL:CAB88977.1, ECO:0000313|Proteomes:UP000001973}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145
RC   {ECO:0000313|Proteomes:UP000001973};
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H.,
RA   Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M.,
RA   Cronin A., Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S.,
RA   Huang C.H., Kieser T., Larke L., Murphy L., Oliver K., O'Neil S.,
RA   Rabbinowitsch E., Rajandream M.A., Rutherford K., Rutter S.,
RA   Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K.,
RA   Warren T., Wietzorrek A., Woodward J., Barrell B.G., Parkhill J.,
RA   Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces
RT   coelicolor A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; AL939130; CAB88977.1; -; Genomic_DNA.
DR   RefSeq; NP_631065.1; NC_003888.3.
DR   RefSeq; WP_011031369.1; NC_003888.3.
DR   ProteinModelPortal; Q9KZF3; -.
DR   STRING; 100226.SCO7000; -.
DR   PRIDE; Q9KZF3; -.
DR   EnsemblBacteria; CAB88977; CAB88977; CAB88977.
DR   GeneID; 1102438; -.
DR   KEGG; sco:SCO7000; -.
DR   PATRIC; fig|100226.15.peg.7102; -.
DR   eggNOG; COG2838; LUCA.
DR   HOGENOM; HOG000240860; -.
DR   InParanoid; Q9KZF3; -.
DR   KO; K00031; -.
DR   OMA; RDSGKMW; -.
DR   OrthoDB; POG091H0B3N; -.
DR   PhylomeDB; Q9KZF3; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001973};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001973}.
FT   REGION      132    139       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       348    348       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       546    546       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       550    550       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     145    145       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     545    545       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        255    255       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        418    418       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   739 AA;  79520 MW;  FCDF3F1D006AFC2D CRC64;
     MTDSTIIYTH TDEAPALATY SFLPVVRAYA SQAGVAVETR DISLAGRIIA LFPEYLTEDQ
     RIPDALAELG ELAKTPAANI IKLPNISASI PQLKAAVAEL QGQGYALPAY PDDPKTDEER
     DIRARYDKVK GSAVNPVLRE GNSDRRAPAS VKNYAKTHPH RMGAWTGESK TNVATMGEND
     FRSTEKSAVI AEDGTLRIEL VGDDGTTTVL RESVPVKKDE VVDASVLRVA ALREFLTAQV
     ARAKAEGILY SVHLKATMMK VSDPIIFGHV VRAFFPKTFA QYGDVLAKAG LTPNDGLGGI
     YKGLESLPEG AEIKASFDAE LAEGPELAMV DSDKGITNLH VPSDVIIDAS MPAMIRTSGH
     MWGADGGEHD ALAVIPDSSY AGVYQAVIED CRANGAYDPS TMGSVPNVGL MAQKAEEYGS
     HDKTFEIPTT GTVRLVDAAG NAVLEQTVSA GDIFRACQTK DAPIRDWVKL AVTRARATGD
     PAVFWLDEGR AHDANLIAKV KQYLSEHDTE GLDIRILDPV EATKLSVERI RRGENTISVT
     GNVLRDYLTD LFPILELGTS AKMLSVVPLM AGGGLFETGA GGSAPKHVQQ LVKEDYLRWD
     SLGEFFALVP SLEKYAEATG NGKAKVLADT LDRATATFLN EDKSPTRRVG GIDNRGSHFY
     LSLYWAQELA KQTDDADLAK AFAPLAETLT ASEQKIVEEL NAVQGKPAEI GGYYQPDPAK
     AAKIMRPSTT WNEALASLA
//
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