UniProt/TrEMBL: R4GBA0

Database: UniProt/TrEMBL
Entry: R4GBA0_ANOCA

LinkDB:  R4GBA0_ANOCA 
Original site:  R4GBA0_ANOCA

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Ontology (2)   
   GO (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (5)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
   ENSEMBL-UP (3)   
Protein sequence (1)   
   RefSeq(pep) (1)   
Protein domain (4)   
   InterPro (2)   
   Pfam (1)   
   PROSITE (1)   
All databases (13)   

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ID   R4GBA0_ANOCA            Unreviewed;       528 AA.
AC   R4GBA0;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   27-MAR-2024, entry version 52.
DE   RecName: Full=UDP-glucuronosyltransferase {ECO:0000256|RuleBase:RU362059};
DE            EC=2.4.1.17 {ECO:0000256|RuleBase:RU362059};
GN   Name=LOC100560189 {ECO:0000313|Ensembl:ENSACAP00000022571.1};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Iguania; Dactyloidae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000022571.1, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000022571.1, ECO:0000313|Proteomes:UP000001646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000022571.1,
RC   ECO:0000313|Proteomes:UP000001646};
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACAP00000022571.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor
CC         beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223,
CC         ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17;
CC         Evidence={ECO:0000256|RuleBase:RU362059};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU362059}; Single-
CC       pass membrane protein {ECO:0000256|RuleBase:RU362059}.
CC   -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00009995, ECO:0000256|RuleBase:RU003718}.
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DR   RefSeq; XP_003222407.1; XM_003222359.3.
DR   AlphaFoldDB; R4GBA0; -.
DR   STRING; 28377.ENSACAP00000022571; -.
DR   Ensembl; ENSACAT00000029988.2; ENSACAP00000022571.1; ENSACAG00000029696.2.
DR   GeneID; 100560189; -.
DR   KEGG; acs:100560189; -.
DR   eggNOG; KOG1192; Eukaryota.
DR   GeneTree; ENSGT00940000153212; -.
DR   HOGENOM; CLU_012949_3_0_1; -.
DR   OrthoDB; 382054at2759; -.
DR   Proteomes; UP000001646; Chromosome 6.
DR   Bgee; ENSACAG00000029696; Expressed in liver and 10 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015020; F:glucuronosyltransferase activity; IBA:GO_Central.
DR   CDD; cd03784; GT1_Gtf-like; 1.
DR   Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR   InterPro; IPR002213; UDP_glucos_trans.
DR   InterPro; IPR035595; UDP_glycos_trans_CS.
DR   PANTHER; PTHR48043; EG:EG0003.4 PROTEIN-RELATED; 1.
DR   PANTHER; PTHR48043:SF140; UDP-GLUCURONOSYLTRANSFERASE 2A1; 1.
DR   Pfam; PF00201; UDPGT; 1.
DR   SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
DR   PROSITE; PS00375; UDPGT; 1.
PE   3: Inferred from homology;
KW   Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW   ECO:0000256|RuleBase:RU003718}; Membrane {ECO:0000256|RuleBase:RU362059};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW   Signal {ECO:0000256|RuleBase:RU362059};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003718};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362059};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362059}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|RuleBase:RU362059"
FT   CHAIN           23..528
FT                   /note="UDP-glucuronosyltransferase"
FT                   /evidence="ECO:0000256|RuleBase:RU362059"
FT                   /id="PRO_5005145379"
FT   TRANSMEM        493..516
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362059"
SQ   SEQUENCE   528 AA;  60610 MW;  7C5030615044430B CRC64;
     MSMKLMLVVP FIMMFLLGSA STGNVLVWPY DYSHWMHMKS VIHELTARGH RVTVVMASSY
     QAAESSESSN FHVEVIPVPF TRKEMEMLTQ DALYLWSYET HKIPFWDSFI KIYSHLMKMQ
     SKYKSFCDNV FWNEKLLQKL ESAAFDVLIS DGVMPGGELL AEKLRVPFLY SLRLTPGNTM
     ERICGHVPAP SSYVPTGLVG LTDRMSFMER TANMLTYLSL DIMFHHFFNK DWDQYFSDVL
     GKPTTLCEIM GKAEIWLIRT YWDFEFPRPL LPNFEYVGGL HCQPAKPLPK EMEEFVQSSG
     EHGIVVFSLG TMIQNLTDEK GNLVALAFSR LPQKVVWRYK GKRPETLGTN TRIYDWIPQN
     DLLGHPKTKA FITHGGTNGI YEAIYHGIPM IGIPMFGDQS DNIAHVCAKG MAIELNINTM
     TAQDLVDAVN TIIHNTTYKE NAVRLSQIHH DQPMKPLDRA VFWIEFVMRH KGAKHLRVAA
     HDLTWYQYHC LDVIAFLISC VALFMFIMVK CCSFCCRKCG ITRKTKIE
//

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