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Database: UniProt/TrEMBL
Entry: R4MCC7_MYCTX
LinkDB: R4MCC7_MYCTX
Original site: R4MCC7_MYCTX 
ID   R4MCC7_MYCTX            Unreviewed;       433 AA.
AC   R4MCC7;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   25-OCT-2017, entry version 24.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   Name=ligB {ECO:0000313|EMBL:AGL28510.1};
GN   ORFNames=J113_21330 {ECO:0000313|EMBL:AGL28510.1};
OS   Mycobacterium tuberculosis CAS/NITR204.
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=1310114 {ECO:0000313|EMBL:AGL28510.1, ECO:0000313|Proteomes:UP000013548};
RN   [1] {ECO:0000313|EMBL:AGL28510.1, ECO:0000313|Proteomes:UP000013548}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CAS/NITR204 {ECO:0000313|EMBL:AGL28510.1,
RC   ECO:0000313|Proteomes:UP000013548};
RX   PubMed=23788533;
RA   Narayanan S., Deshpande U.;
RT   "Whole-Genome Sequences of Four Clinical Isolates of Mycobacterium
RT   tuberculosis from Tamil Nadu, South India.";
RL   Genome Announc. 1:e00186-13(2013).
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000256|RuleBase:RU000617}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|RuleBase:RU004196}.
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DR   EMBL; CP005386; AGL28510.1; -; Genomic_DNA.
DR   EnsemblBacteria; AGL28510; AGL28510; J113_21330.
DR   KEGG; mtuc:J113_21330; -.
DR   PATRIC; fig|1310114.3.peg.4495; -.
DR   KO; K10747; -.
DR   OrthoDB; POG091H0BGA; -.
DR   Proteomes; UP000013548; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   SUPFAM; SSF117018; SSF117018; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000617};
KW   Complete proteome {ECO:0000313|Proteomes:UP000013548};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|RuleBase:RU000617, ECO:0000313|EMBL:AGL28510.1};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000617}.
FT   DOMAIN      214    338       DNA_LIGASE_A3. {ECO:0000259|PROSITE:
FT                                PS50160}.
SQ   SEQUENCE   433 AA;  45916 MW;  E24277A51FDF2CF0 CRC64;
     MTVTGVDATL SKIGTLPGKG SQAQRAALVA ELFSAATEAE QTFLLRLLGG ELRQGAKGGI
     MADAVAQAAG LPAATVQRAA MLGGDLAAAA AAGLSGAALD TFTLRVGRPI GPMLAQTATS
     VHDALERHGG TTIFEAKLDG ARVQIHRAND QVRIYTRSLD DVTARLPEVV EATLALPVRD
     LVADGEAIAL CPDNRPQRFQ VTASRFGRSV DVAAARATQP LSVFFFDILH RDGTDLLEAP
     TTERLAALDA LVPARHRVDR LITSDPTDAA NFLDATLAAG HEGVMAKAPA ARYLAGRRGA
     GWLKVKPVHT LDLVVLAVEW GSGRRRGKLS NIHLGARDPA TGGFVMVGKT FKGMTDAMLD
     WQTTRFHEIA VGPTDGYVVQ LRPEQVVEVA LDGVQRSSRY PGGLALRFAR VVRYRADKDP
     AEADTIDAVR ALY
//
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