ID R4Q8V0_HELPX Unreviewed; 314 AA.
AC R4Q8V0;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE RecName: Full=Catalase-related peroxidase {ECO:0000256|PIRNR:PIRNR000296};
DE EC=1.11.1.- {ECO:0000256|PIRNR:PIRNR000296};
GN ORFNames=K750_03890 {ECO:0000313|EMBL:AGL69729.1};
OS Helicobacter pylori UM037.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=1321939 {ECO:0000313|EMBL:AGL69729.1, ECO:0000313|Proteomes:UP000013898};
RN [1] {ECO:0000313|EMBL:AGL69729.1, ECO:0000313|Proteomes:UP000013898}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UM037 {ECO:0000313|EMBL:AGL69729.1,
RC ECO:0000313|Proteomes:UP000013898};
RA Khosravi Y., Rehvathy V., Amoyo A., Seow S., Ong J., Susana W., Primo B.,
RA Meredith A., Siddarth S., Pettersson S., Loke M., Goh K., Vadivelu J.;
RT "Draft Genome Sequences of Helicobacter pylori Strain UM037 and UM066 using
RT PacBio Sequencing Platform.";
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Has an organic peroxide-dependent peroxidase activity.
CC {ECO:0000256|PIRNR:PIRNR000296}.
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413;
CC Evidence={ECO:0000256|PIRNR:PIRNR000296};
CC -!- SIMILARITY: Belongs to the catalase family.
CC {ECO:0000256|PIRNR:PIRNR000296}.
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DR EMBL; CP005492; AGL69729.1; -; Genomic_DNA.
DR RefSeq; WP_015644059.1; NZ_AUSI01000044.1.
DR AlphaFoldDB; R4Q8V0; -.
DR KEGG; hpyi:K750_03890; -.
DR PATRIC; fig|1321939.6.peg.807; -.
DR HOGENOM; CLU_045961_2_0_7; -.
DR Proteomes; UP000013898; Chromosome.
DR GO; GO:0004096; F:catalase activity; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR CDD; cd08153; srpA_like; 1.
DR Gene3D; 1.20.1280.120; -; 1.
DR Gene3D; 2.40.180.10; Catalase core domain; 1.
DR InterPro; IPR018028; Catalase.
DR InterPro; IPR011614; Catalase_core.
DR InterPro; IPR020835; Catalase_sf.
DR InterPro; IPR024168; Catalase_SrpA-type_pred.
DR PANTHER; PTHR11465; CATALASE; 1.
DR PANTHER; PTHR11465:SF9; CATALASE; 1.
DR Pfam; PF00199; Catalase; 1.
DR PIRSF; PIRSF000296; SrpA; 1.
DR SUPFAM; SSF56634; Heme-dependent catalase-like; 1.
PE 3: Inferred from homology;
KW Heme {ECO:0000256|PIRNR:PIRNR000296, ECO:0000256|PIRSR:PIRSR000296-2};
KW Iron {ECO:0000256|PIRNR:PIRNR000296, ECO:0000256|PIRSR:PIRSR000296-2};
KW Metal-binding {ECO:0000256|PIRNR:PIRNR000296,
KW ECO:0000256|PIRSR:PIRSR000296-2};
KW Oxidoreductase {ECO:0000256|PIRNR:PIRNR000296};
KW Peroxidase {ECO:0000256|PIRNR:PIRNR000296};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..314
FT /note="Catalase-related peroxidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004369831"
FT DOMAIN 43..309
FT /note="Catalase core"
FT /evidence="ECO:0000259|Pfam:PF00199"
FT ACT_SITE 45
FT /evidence="ECO:0000256|PIRSR:PIRSR000296-1"
FT BINDING 306
FT /ligand="heme"
FT /ligand_id="ChEBI:CHEBI:30413"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000256|PIRSR:PIRSR000296-2"
SQ SEQUENCE 314 AA; 35942 MW; C54CD6C8415718B3 CRC64;
MKKIGLSLCL VLSLGFLKAH EVSAEEIADI FYKLNAKEPK MKINHTKGFC AKGVFLPNLQ
AREDLDVPLL NEKEIPASVR YSLGGVAMDD KSKVRGMALK LENQNASWTM VMLNTEINFA
KNPKEFAQFF EMRIPKNGKV DEARIKKLYE EVPSYRNFAA YTKTIGISSS VANTPYYSVH
AFRFKDKKEE LLPARWKFVP KDGVKYLNPQ ELKQKDSNYL LSSFQQHLKN KPIEYQMYLV
FANKNDATND TTALWKGKHK ELLVGTLKVE KYEGMGCNKD VYFPADLPKG VEAPTDPLFQ
IRNEVYGITF SRRQ
//