GenomeNet

Database: UniProt/TrEMBL
Entry: R4T0A5_AMYOR
LinkDB: R4T0A5_AMYOR
Original site: R4T0A5_AMYOR 
ID   R4T0A5_AMYOR            Unreviewed;       394 AA.
AC   R4T0A5;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   07-JUN-2017, entry version 24.
DE   RecName: Full=Kynureninase {ECO:0000256|PIRNR:PIRNR038800};
DE            EC=3.7.1.3 {ECO:0000256|PIRNR:PIRNR038800};
GN   ORFNames=AORI_6446 {ECO:0000313|EMBL:AGM09029.1};
OS   Amycolatopsis orientalis HCCB10007.
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Amycolatopsis.
OX   NCBI_TaxID=1156913 {ECO:0000313|EMBL:AGM09029.1, ECO:0000313|Proteomes:UP000013968};
RN   [1] {ECO:0000313|EMBL:AGM09029.1, ECO:0000313|Proteomes:UP000013968}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HCCB10007 {ECO:0000313|EMBL:AGM09029.1};
RX   PubMed=23627759; DOI=10.1186/1471-2164-14-289;
RA   Tang B., Wang Q., Yang M., Xie F., Zhu Y., Zhuo Y., Wang S., Gao H.,
RA   Ding X., Zhang L., Zhao G., Zheng H.;
RT   "ContigScape: a Cytoscape plugin facilitating microbial genome gap
RT   closing.";
RL   BMC Genomics 14:289-289(2013).
CC   -!- FUNCTION: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-
CC       hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-
CC       hydroxyanthranilic acid (3-OHAA), respectively.
CC       {ECO:0000256|PIRNR:PIRNR038800}.
CC   -!- CATALYTIC ACTIVITY: L-3-hydroxykynurenine + H(2)O = 3-
CC       hydroxyanthranilate + L-alanine. {ECO:0000256|PIRNR:PIRNR038800}.
CC   -!- CATALYTIC ACTIVITY: L-kynurenine + H(2)O = anthranilate + L-
CC       alanine. {ECO:0000256|PIRNR:PIRNR038800}.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|PIRNR:PIRNR038800};
CC   -!- PATHWAY: Amino-acid degradation; L-kynurenine degradation; L-
CC       alanine and anthranilate from L-kynurenine: step 1/1.
CC       {ECO:0000256|PIRNR:PIRNR038800}.
CC   -!- PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate
CC       from L-kynurenine: step 2/3. {ECO:0000256|PIRNR:PIRNR038800}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|PIRNR:PIRNR038800}.
CC   -!- SIMILARITY: Belongs to the kynureninase family.
CC       {ECO:0000256|PIRNR:PIRNR038800}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CP003410; AGM09029.1; -; Genomic_DNA.
DR   RefSeq; WP_016336743.1; NC_021252.1.
DR   EnsemblBacteria; AGM09029; AGM09029; AORI_6446.
DR   KEGG; aoi:AORI_6446; -.
DR   PATRIC; fig|1156913.3.peg.6574; -.
DR   KO; K01556; -.
DR   OrthoDB; POG091H0D63; -.
DR   UniPathway; UPA00253; UER00329.
DR   UniPathway; UPA00334; UER00455.
DR   Proteomes; UP000013968; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0030429; F:kynureninase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0097053; P:L-kynurenine catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0009435; P:NAD biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006569; P:tryptophan catabolic process; IEA:InterPro.
DR   Gene3D; 3.40.640.10; -; 1.
DR   Gene3D; 3.90.1150.10; -; 1.
DR   InterPro; IPR000192; Aminotrans_V_dom.
DR   InterPro; IPR010111; Kynureninase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major_sub1.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_sub2.
DR   PANTHER; PTHR14084; PTHR14084; 1.
DR   Pfam; PF00266; Aminotran_5; 1.
DR   PIRSF; PIRSF038800; KYNU; 1.
DR   SUPFAM; SSF53383; SSF53383; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000013968};
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR038800};
KW   Pyridine nucleotide biosynthesis {ECO:0000256|PIRNR:PIRNR038800};
KW   Pyridoxal phosphate {ECO:0000256|PIRNR:PIRNR038800};
KW   Reference proteome {ECO:0000313|Proteomes:UP000013968}.
FT   DOMAIN       81    293       Aminotran_5. {ECO:0000259|Pfam:PF00266}.
SQ   SEQUENCE   394 AA;  42306 MW;  AAD6B5E2A9F2441F CRC64;
     MVAVTDLVAE AAALDVADPL AHKRNEFDLD TDVAYFDGNS LGAPPKHVAG RLAAIVREQW
     GGRLIRSWSE GWWEAPVRVG ERIAPLVGAA PGQVVVADST SVDLFKALVA ATRLRPGRDE
     ILVDADTFPT DGYIADEAAR LTGRTVRRVV AEEMPAQVSE RTAVALINHV DYVTGRAHDM
     AELTAALHRA GALALWDLCH SVGALPVELD AAGVDLAVGC TYKFLNGGPG SPAFLYVAAK
     WLDRFDQPLA GWAGDRDPFA MRGAYEAHAS IARGRAGTPD ILSLLALDAA LDVWDGVDRG
     LLREKGLALG DFFFRCADEL LDGAKIPTPR GRDRGHQVSV LDDDAAKTMA ALIDRGVIGD
     FRPPNVLRFG LAPLYTTYGE VLRAVTTLRE LRAE
//
DBGET integrated database retrieval system