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Database: UniProt/TrEMBL
Entry: R7SRX2_DICSQ
LinkDB: R7SRX2_DICSQ
Original site: R7SRX2_DICSQ 
ID   R7SRX2_DICSQ            Unreviewed;       408 AA.
AC   R7SRX2;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   31-JAN-2018, entry version 26.
DE   RecName: Full=Histone deacetylase {ECO:0000256|SAAS:SAAS00894283};
DE            EC=3.5.1.98 {ECO:0000256|SAAS:SAAS00894283};
GN   ORFNames=DICSQDRAFT_156483 {ECO:0000313|EMBL:EJF58949.1};
OS   Dichomitus squalens (strain LYAD-421) (Western red white-rot fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina;
OC   Agaricomycetes; Polyporales; Polyporaceae; Dichomitus.
OX   NCBI_TaxID=732165 {ECO:0000313|EMBL:EJF58949.1, ECO:0000313|Proteomes:UP000053319};
RN   [1] {ECO:0000313|EMBL:EJF58949.1, ECO:0000313|Proteomes:UP000053319}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LYAD-421 SS1 {ECO:0000313|EMBL:EJF58949.1,
RC   ECO:0000313|Proteomes:UP000053319};
RX   PubMed=22745431; DOI=10.1126/science.1221748;
RA   Floudas D., Binder M., Riley R., Barry K., Blanchette R.A.,
RA   Henrissat B., Martinez A.T., Otillar R., Spatafora J.W., Yadav J.S.,
RA   Aerts A., Benoit I., Boyd A., Carlson A., Copeland A., Coutinho P.M.,
RA   de Vries R.P., Ferreira P., Findley K., Foster B., Gaskell J.,
RA   Glotzer D., Gorecki P., Heitman J., Hesse C., Hori C., Igarashi K.,
RA   Jurgens J.A., Kallen N., Kersten P., Kohler A., Kues U., Kumar T.K.,
RA   Kuo A., LaButti K., Larrondo L.F., Lindquist E., Ling A., Lombard V.,
RA   Lucas S., Lundell T., Martin R., McLaughlin D.J., Morgenstern I.,
RA   Morin E., Murat C., Nagy L.G., Nolan M., Ohm R.A., Patyshakuliyeva A.,
RA   Rokas A., Ruiz-Duenas F.J., Sabat G., Salamov A., Samejima M.,
RA   Schmutz J., Slot J.C., St John F., Stenlid J., Sun H., Sun S.,
RA   Syed K., Tsang A., Wiebenga A., Young D., Pisabarro A., Eastwood D.C.,
RA   Martin F., Cullen D., Grigoriev I.V., Hibbett D.S.;
RT   "The Paleozoic origin of enzymatic lignin decomposition reconstructed
RT   from 31 fungal genomes.";
RL   Science 336:1715-1719(2012).
CC   -!- CATALYTIC ACTIVITY: Hydrolysis of an N(6)-acetyl-lysine residue of
CC       a histone to yield a deacetylated histone.
CC       {ECO:0000256|SAAS:SAAS00894227}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00894298}.
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DR   EMBL; JH719429; EJF58949.1; -; Genomic_DNA.
DR   RefSeq; XP_007368252.1; XM_007368190.1.
DR   EnsemblFungi; EJF58949; EJF58949; DICSQDRAFT_156483.
DR   GeneID; 18837630; -.
DR   KEGG; dsq:DICSQDRAFT_156483; -.
DR   KO; K11405; -.
DR   OMA; YGGRHHC; -.
DR   Proteomes; UP000053319; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:UniProtKB-EC.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.800.20; -; 1.
DR   InterPro; IPR000286; His_deacetylse.
DR   InterPro; IPR003084; His_deacetylse_1.
DR   InterPro; IPR023801; His_deacetylse_dom.
DR   InterPro; IPR037138; His_deacetylse_dom_sf.
DR   InterPro; IPR023696; Ureohydrolase_dom_sf.
DR   PANTHER; PTHR10625; PTHR10625; 3.
DR   Pfam; PF00850; Hist_deacetyl; 1.
DR   PRINTS; PR01270; HDASUPER.
DR   PRINTS; PR01271; HISDACETLASE.
DR   SUPFAM; SSF52768; SSF52768; 1.
PE   4: Predicted;
KW   Chromatin regulator {ECO:0000256|SAAS:SAAS00894233};
KW   Complete proteome {ECO:0000313|Proteomes:UP000053319};
KW   Hydrolase {ECO:0000256|SAAS:SAAS00870288};
KW   Nucleus {ECO:0000256|SAAS:SAAS00894277};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053319};
KW   Transcription {ECO:0000256|SAAS:SAAS00894309};
KW   Transcription regulation {ECO:0000256|SAAS:SAAS00894290}.
FT   DOMAIN       27    343       Hist_deacetyl. {ECO:0000259|Pfam:
FT                                PF00850}.
SQ   SEQUENCE   408 AA;  45103 MW;  890D18CA7AC781B2 CRC64;
     MQNSGEERRV AYVVSNELVK ISSQLPSNRN RSFLVHSLVK AFGLLKPPGR DSVAGIQPLR
     PLPAQFKELS AYHDRDYLER LLQGEVYGAT NDTQHTEYGL EEDCPAFPHL PDYVRYVAGA
     TLAAARALKD DTADISVCWD GGRHHAQKAR ASGFCYVADC VLAILLLKRS LPATTERPLF
     RPRVMYLDFD LHFADGVSEA FYSSSKHSSS PQVLTLSIHH TAPGFFPVSH LAGLTDPQDS
     QFDPFTLSLP LERGASNKTF HRIWPLIEHV KDAFQPHYVV VQCGADGLSG DPYATWNWSL
     GGEGGMGWCV DRICHWPSRT LLLGGGGYNS PNVARAWTFL TSIALGRILP LDSDIPDHGA
     FPLYASSFTL DVPSGNIQDQ NTDAYLERVD QVFAQVVDAI REKMRSSS
//
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