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Database: UniProt/TrEMBL
Entry: S3DT02_GLAL2
LinkDB: S3DT02_GLAL2
Original site: S3DT02_GLAL2 
ID   S3DT02_GLAL2            Unreviewed;       971 AA.
AC   S3DT02;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   07-JUN-2017, entry version 17.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   ORFNames=GLAREA_00723 {ECO:0000313|EMBL:EPE29563.1};
OS   Glarea lozoyensis (strain ATCC 20868 / MF5171).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Helotiales; Helotiaceae; Glarea.
OX   NCBI_TaxID=1116229 {ECO:0000313|EMBL:EPE29563.1, ECO:0000313|Proteomes:UP000016922};
RN   [1] {ECO:0000313|EMBL:EPE29563.1, ECO:0000313|Proteomes:UP000016922}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 20868 / MF5171 {ECO:0000313|Proteomes:UP000016922};
RX   PubMed=23688303; DOI=10.1186/1471-2164-14-339;
RA   Chen L., Yue Q., Zhang X., Xiang M., Wang C., Li S., Che Y.,
RA   Ortiz-Lopez F.J., Bills G.F., Liu X., An Z.;
RT   "Genomics-driven discovery of the pneumocandin biosynthetic gene
RT   cluster in the fungus Glarea lozoyensis.";
RL   BMC Genomics 14:339-339(2013).
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000256|RuleBase:RU000617}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|RuleBase:RU004196}.
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DR   EMBL; KE145367; EPE29563.1; -; Genomic_DNA.
DR   RefSeq; XP_008083672.1; XM_008085481.1.
DR   EnsemblFungi; EPE29563; EPE29563; GLAREA_00723.
DR   GeneID; 19459781; -.
DR   OrthoDB; EOG092C18KW; -.
DR   Proteomes; UP000016922; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd00027; BRCT; 1.
DR   Gene3D; 1.10.3260.10; -; 1.
DR   Gene3D; 3.40.50.10190; -; 2.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR029710; LIG4.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR10459:SF84; PTHR10459:SF84; 1.
DR   Pfam; PF16589; BRCT_2; 1.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   SMART; SM00292; BRCT; 2.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF52113; SSF52113; 2.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS50172; BRCT; 2.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000617};
KW   Complete proteome {ECO:0000313|Proteomes:UP000016922};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|RuleBase:RU000617, ECO:0000313|EMBL:EPE29563.1};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000617};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016922}.
FT   DOMAIN      431    542       DNA_LIGASE_A3. {ECO:0000259|PROSITE:
FT                                PS50160}.
FT   DOMAIN      701    786       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   DOMAIN      905    971       BRCT. {ECO:0000259|PROSITE:PS50172}.
SQ   SEQUENCE   971 AA;  111017 MW;  89272598DA128457 CRC64;
     MPASQRLPDD GANEEDQSQY HRNAASNEDL DEKYPNRPHN HSRTLFFGDL LTDLFNPLNE
     NKKRPSGPKI ARAKVGPHGP GVKSAHEVRR SIIERFISKW RTVVGNDFYP ALRLILPEKD
     RDRLMYGLKE KAIGKIVVRM LSIAKGSDDA SDVLNWKLPA KNASTQMAGD FAGRCYELLK
     GRAMINGKGD MRIAEVNELL DDLSKEGKED AQLKIFDKFY HRMSADELMW LIRIILRQMK
     IGASEKTILE LWHPNAEALF NVCSSLRRVC WELTDPESIL DSEDTGVELM ACFQPQLAQF
     QQHNFQKMVD KMGMPAENPA FWIEEKLDGE RMQMHMVVDD SHPGGKRFGF WSRKGKDYTY
     LYGDGYEDDN SALTRHIKNA FDPRLRNIIL DGEMITWDPD IDKIVAFGTL KTAALSEQKN
     PFQTSGQRPL FRVFDCLYLN DRDITRYTLR DRRKALEKVL TDVYRRIELH HYEEVQEAQA
     IEPALRQVVA EASEGLVLKN PESPYRLSMR DNVWMKVKPE YMMDFGESLD CIVIGGYYGS
     GRANPMKCFS FCKVGGGFRA EDYAAIRHLT GGKWVDWNRD NPPNEFIELA GGDRQLERPD
     MWIKPSDSVV LEVKAASVGP SESFKTNYTL RFPRFKKLRE DKDWQSALSL SEFALLKTKV
     EAESSQRGFV VQAKRKMTKR LKKEVVIAGT DSKIKTPYAG PQTKVFEGLD FHVMTDMLQP
     FKKSKAELEQ MIKANGGSIY ASPTAKEHII CIAEKRPVKV ASIIKRGETN IVRPAWLFDA
     IQQSEIDGPH RSRFLIPFEP THMFHLIESS REDIEGNVDI YGDSYMRDIT PLELGKLCEE
     MLHPKTQDFD AGMFRLQLEE RGRGIGELPG NIFGRHMIRF VSSARTDAEK DIDLFLLRTQ
     FSFAGGKIAE SDGADGITHF VVVDEGDEDV VSGLRRKIAE RRGPVPRIVR LKWLRDSWAE
     KTVLDEERYA I
//
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