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Database: UniProt/TrEMBL
Entry: S5TW48_9GAMM
LinkDB: S5TW48_9GAMM
Original site: S5TW48_9GAMM 
ID   S5TW48_9GAMM            Unreviewed;       748 AA.
AC   S5TW48;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   07-JUN-2017, entry version 25.
DE   SubName: Full=Isocitrate dehydrogenase {ECO:0000313|EMBL:AGS39223.1};
DE            EC=1.1.1.42 {ECO:0000313|EMBL:AGS39223.1};
GN   Name=icd {ECO:0000313|EMBL:AGS39223.1};
GN   ORFNames=CYCME_0890 {ECO:0000313|EMBL:AGS39223.1};
OS   Cycloclasticus zancles 78-ME.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Thiotrichales;
OC   Piscirickettsiaceae; Cycloclasticus.
OX   NCBI_TaxID=1198232 {ECO:0000313|EMBL:AGS39223.1, ECO:0000313|Proteomes:UP000015380};
RN   [1] {ECO:0000313|EMBL:AGS39223.1, ECO:0000313|Proteomes:UP000015380}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=7-ME {ECO:0000313|Proteomes:UP000015380};
RA   Yakimov M.M., Messina E., Genovese M., Denaro R., Crisafi F.,
RA   Russo D., Cappello S., Santisi S., Smedile F., Golyshina O.V.,
RA   Tran H., Pieper D.H., Golyshin P.N., Giuliano L.;
RT   "Between feast and famine: a lifestyle of most important marine PAH-
RT   degrading bacterium Cycloclasticus sp. 7ME.";
RL   Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP005996; AGS39223.1; -; Genomic_DNA.
DR   EnsemblBacteria; AGS39223; AGS39223; CYCME_0890.
DR   KEGG; cza:CYCME_0890; -.
DR   PATRIC; fig|1198232.3.peg.889; -.
DR   KO; K00031; -.
DR   OrthoDB; POG091H0B3N; -.
DR   BioCyc; CZAN1198232:G1355-890-MONOMER; -.
DR   Proteomes; UP000015380; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000015380};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Oxidoreductase {ECO:0000313|EMBL:AGS39223.1}.
FT   REGION      139    146       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       357    357       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       555    555       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       559    559       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     152    152       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     554    554       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        262    262       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        427    427       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   748 AA;  83010 MW;  9B190B1300A912AE CRC64;
     MHGERMTVKK SKIIYTLTDE APLLATASFL PIVEAFAGAA GIDVEVSDIS LASRVLATFA
     DQLPDDQKVP DALSELGRLT QNPETNIIKL PNISASVPQL KAIINELQGK GFDIPNYPED
     PQTDEEKALQ QKYGKVLGSA VNPVLREGNS DRRAPKAVKE YAKKNPHSMG KWSQASRTHV
     SHMRSGDFYS SEKSLTLDKA CKVNIEFVAK NGEVTVLKKG LALQEGEIID SMFMSKKQLC
     AYLEDEMNDA KETGVMFSFH VKATMMKVSH PIVFGHAVKV YYKDLFEKHG KLFDELGVNP
     NDGLSSVYEH IEKLPASIKE EILSDMHACY EKRPELAMVD SAKGISNLHT PNEVIVDASM
     PAMIRAGGKM WGPDGKMKDT KAVMPESTFA RIYQEIINFC KTHGEFDPTT MGTVPNVGLM
     AQKAEEYGSH DKTFEMKADG STRIVDEEGN VLLEMDVEEG DIWRMCQVKD APIQDWVKLA
     VKRARLSNTP AVFWLDKYRP HENELIKKVE KYLKDHDLTG VDIKIKSQTR AMRYTLERIL
     RGKDTISVTG NILRDYLTDL FPILELGTSA KMLSIVPLMA GGGLFETGAG GSAPKHVKQL
     IEENHLRWDS LGEFLALCAS LEHTAISDGN AKAAVLAKTL DEATAKLLDT GKSPSRKTGE
     LDNRGSHFYL ALYWAQALAE QTEDEALQTH FQPLAASLTE NEEKIVGTLT TEQWHAVDIG
     GYYKPDVDKV REVMRPSEIF NEALASLK
//
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