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Database: UniProt/TrEMBL
Entry: T1G3D8_HELRO
LinkDB: T1G3D8_HELRO
Original site: T1G3D8_HELRO 
ID   T1G3D8_HELRO            Unreviewed;       260 AA.
AC   T1G3D8;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-SEP-2017, entry version 28.
DE   RecName: Full=Superoxide dismutase {ECO:0000256|RuleBase:RU000414};
DE            EC=1.15.1.1 {ECO:0000256|RuleBase:RU000414};
GN   Name=20215586 {ECO:0000313|EnsemblMetazoa:HelroP78629};
GN   ORFNames=HELRODRAFT_78629 {ECO:0000313|EMBL:ESO04737.1};
OS   Helobdella robusta (Californian leech).
OC   Eukaryota; Metazoa; Lophotrochozoa; Annelida; Clitellata; Hirudinea;
OC   Rhynchobdellida; Glossiphoniidae; Helobdella.
OX   NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP78629, ECO:0000313|Proteomes:UP000015101};
RN   [1] {ECO:0000313|EnsemblMetazoa:HelroP78629, ECO:0000313|Proteomes:UP000015101}
RP   NUCLEOTIDE SEQUENCE.
RA   Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA   Otillar R.P., Terry A.Y., Boore J.L., Simakov O., Marletaz F.,
RA   Cho S.-J., Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T.,
RA   Lv J., Arendt D., Savage R., Osoegawa K., de Jong P., Lindberg D.R.,
RA   Seaver E.C., Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL   Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ESO04737.1, ECO:0000313|EnsemblMetazoa:HelroP78629, ECO:0000313|Proteomes:UP000015101}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23254933; DOI=10.1038/nature11696;
RA   Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA   Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA   Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H.,
RA   Aerts A., Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V.,
RA   Lindberg D.R., Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT   "Insights into bilaterian evolution from three spiralian genomes.";
RL   Nature 493:526-531(2013).
RN   [3] {ECO:0000313|EnsemblMetazoa:HelroP78629}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- FUNCTION: Destroys radicals which are normally produced within the
CC       cells and which are toxic to biological systems.
CC       {ECO:0000256|RuleBase:RU000414}.
CC   -!- CATALYTIC ACTIVITY: 2 superoxide + 2 H(+) = O(2) + H(2)O(2).
CC       {ECO:0000256|RuleBase:RU000414}.
CC   -!- SIMILARITY: Belongs to the iron/manganese superoxide dismutase
CC       family. {ECO:0000256|RuleBase:RU000414}.
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DR   EMBL; AMQM01004207; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KB096457; ESO04737.1; -; Genomic_DNA.
DR   RefSeq; XP_009017316.1; XM_009019068.1.
DR   EnsemblMetazoa; HelroT78629; HelroP78629; HelroG78629.
DR   GeneID; 20215586; -.
DR   KEGG; hro:HELRODRAFT_78629; -.
DR   CTD; 20215586; -.
DR   KO; K04564; -.
DR   OMA; YWATMSP; -.
DR   OrthoDB; EOG091G0UM0; -.
DR   Proteomes; UP000015101; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004784; F:superoxide dismutase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR001189; Mn/Fe_SOD.
DR   InterPro; IPR019833; Mn/Fe_SOD_BS.
DR   InterPro; IPR019832; Mn/Fe_SOD_C.
DR   InterPro; IPR019831; Mn/Fe_SOD_N.
DR   Pfam; PF02777; Sod_Fe_C; 1.
DR   Pfam; PF00081; Sod_Fe_N; 1.
DR   PIRSF; PIRSF000349; SODismutase; 1.
DR   PRINTS; PR01703; MNSODISMTASE.
DR   SUPFAM; SSF46609; SSF46609; 1.
DR   SUPFAM; SSF54719; SSF54719; 1.
DR   PROSITE; PS00088; SOD_MN; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000015101};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000349-1,
KW   ECO:0000256|RuleBase:RU000414};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000414};
KW   Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    260       Superoxide dismutase. {ECO:0000256|SAM:
FT                                SignalP}.
FT                                /FTId=PRO_5010981114.
FT   DOMAIN       31    124       Sod_Fe_N. {ECO:0000259|Pfam:PF00081}.
FT   DOMAIN      134    239       Sod_Fe_C. {ECO:0000259|Pfam:PF02777}.
FT   METAL        56     56       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000349-1}.
FT   METAL       116    116       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000349-1}.
FT   METAL       208    208       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000349-1}.
FT   METAL       212    212       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000349-1}.
SQ   SEQUENCE   260 AA;  30770 MW;  738C786549DBD0A5 CRC64;
     MHFSHLIVLL FCVQNSFSLS PHEVPAENLI EYPLPKLEYD FDDLEPYIDG ATVRAHYNGH
     HESYRKKMNE FLQKWRSSVS SKLPYQSLYQ ILQNLNKVPH DLEISILNNV GGYVNHALYW
     SILSPNPSKQ LRLPEGHLLE RIKSDFDSFD EFKNKFTAEA LKLFGSGYVW LVSEKPNFDG
     SEGRLRIVSS SNQDSPITFK LLPLLVIDVW EHAYYLKHQY KRVEHVEDFW YLVDWKKVDA
     LVKFWEEFNW ELHGTYREDL
//
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