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Database: UniProt/TrEMBL
Entry: T2M5F0_HYDVU
LinkDB: T2M5F0_HYDVU
Original site: T2M5F0_HYDVU 
ID   T2M5F0_HYDVU            Unreviewed;       327 AA.
AC   T2M5F0;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   07-JUN-2017, entry version 25.
DE   SubName: Full=Histone-lysine N-methyltransferase SUV39H2 {ECO:0000313|EMBL:CDG67359.1};
GN   Name=SUV39H2 {ECO:0000313|EMBL:CDG67359.1};
OS   Hydra vulgaris (Hydra) (Hydra attenuata).
OC   Eukaryota; Metazoa; Cnidaria; Hydrozoa; Hydroidolina; Anthoathecata;
OC   Aplanulata; Hydridae; Hydra.
OX   NCBI_TaxID=6087 {ECO:0000313|EMBL:CDG67359.1};
RN   [1] {ECO:0000313|EMBL:CDG67359.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Whole animals {ECO:0000313|EMBL:CDG67359.1};
RX   PubMed=24065732; DOI=10.1093/gbe/evt142;
RA   Wenger Y., Galliot B.;
RT   "Punctuated emergences of genetic and phenotypic innovations in
RT   eumetazoan, bilaterian, euteleostome, and hominidae ancestors.";
RL   Genome Biol. Evol. 5:1949-1968(2013).
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] =
CC       S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
CC       {ECO:0000256|SAAS:SAAS00591578}.
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|SAAS:SAAS00563877}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00574581}.
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DR   EMBL; HAAD01001127; CDG67359.1; -; mRNA.
DR   RefSeq; XP_002162409.3; XM_002162373.3.
DR   GeneID; 100204516; -.
DR   KEGG; hmg:100204516; -.
DR   KO; K11419; -.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR011381; Histone_H3-K9_MeTrfase.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR007728; Pre-SET_dom.
DR   InterPro; IPR001214; SET_dom.
DR   Pfam; PF05033; Pre-SET; 1.
DR   Pfam; PF00856; SET; 1.
DR   PIRSF; PIRSF009343; SUV39_SET; 1.
DR   SMART; SM00468; PreSET; 1.
DR   SMART; SM00317; SET; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS50867; PRE_SET; 1.
DR   PROSITE; PS50280; SET; 1.
PE   2: Evidence at transcript level;
KW   Chromosome {ECO:0000256|SAAS:SAAS00508265};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009343-2};
KW   Methyltransferase {ECO:0000256|SAAS:SAAS00590675,
KW   ECO:0000313|EMBL:CDG67359.1};
KW   Nucleus {ECO:0000256|SAAS:SAAS00574642};
KW   S-adenosyl-L-methionine {ECO:0000256|SAAS:SAAS00591079};
KW   Transferase {ECO:0000256|SAAS:SAAS00591533,
KW   ECO:0000313|EMBL:CDG67359.1}; Zinc {ECO:0000256|PIRSR:PIRSR009343-2}.
FT   DOMAIN      112    172       Pre-SET. {ECO:0000259|PROSITE:PS50867}.
FT   DOMAIN      175    299       SET. {ECO:0000259|PROSITE:PS50280}.
FT   DOMAIN      311    327       Post-SET. {ECO:0000259|PROSITE:PS50868}.
FT   METAL       114    114       Zinc 1. {ECO:0000256|PIRSR:PIRSR009343-
FT                                2}.
FT   METAL       114    114       Zinc 2. {ECO:0000256|PIRSR:PIRSR009343-
FT                                2}.
FT   METAL       116    116       Zinc 1. {ECO:0000256|PIRSR:PIRSR009343-
FT                                2}.
FT   METAL       125    125       Zinc 1. {ECO:0000256|PIRSR:PIRSR009343-
FT                                2}.
FT   METAL       127    127       Zinc 2. {ECO:0000256|PIRSR:PIRSR009343-
FT                                2}.
FT   METAL       154    154       Zinc 2. {ECO:0000256|PIRSR:PIRSR009343-
FT                                2}.
FT   METAL       154    154       Zinc 3. {ECO:0000256|PIRSR:PIRSR009343-
FT                                2}.
FT   METAL       158    158       Zinc 2. {ECO:0000256|PIRSR:PIRSR009343-
FT                                2}.
FT   METAL       160    160       Zinc 3. {ECO:0000256|PIRSR:PIRSR009343-
FT                                2}.
FT   METAL       164    164       Zinc 3. {ECO:0000256|PIRSR:PIRSR009343-
FT                                2}.
FT   METAL       259    259       Zinc 4. {ECO:0000256|PIRSR:PIRSR009343-
FT                                2}.
FT   METAL       315    315       Zinc 4. {ECO:0000256|PIRSR:PIRSR009343-
FT                                2}.
FT   METAL       317    317       Zinc 4. {ECO:0000256|PIRSR:PIRSR009343-
FT                                2}.
FT   METAL       322    322       Zinc 4. {ECO:0000256|PIRSR:PIRSR009343-
FT                                2}.
SQ   SEQUENCE   327 AA;  37534 MW;  BF33784B8C1BF0C7 CRC64;
     MGKPKPKKDK PLLACKVVVL EDVNQLAKKY RGKFQLTLKT IKKKGYENCI DPAQNMLLVQ
     WETLLNKICH EDPVIAVENF VDNEGPPDNF TYVRQNITHG LANDLLDPNF LAGCECFPRC
     SQNTCSCPKN SGHKFAYDRN KRVLLPPQSP IYECNKRCKC GDDCPNRVLQ KGLTVRVCIF
     RTDNGRGWGL KTREFIPKDM FVVEYVGEVI TSDDAERRGK LYDERQQTYL FDLDFNGDPT
     FTIDAHEYGN VSHFINHSCD PNLRVFTVWV DTLDPRLPRL GLFALRDIKQ GEELTFDYTC
     GQKESKTSNE IKMYCACGAP NCRKYLF
//
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