ID   T2ME06_HYDVU            Unreviewed;       914 AA.
AC   T2ME06;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   27-MAR-2024, entry version 51.
DE   SubName: Full=Rap guanine nucleotide exchange factor 1 {ECO:0000313|EMBL:CDG70130.1, ECO:0000313|RefSeq:XP_002156706.1};
GN   Name=RAPGEF1 {ECO:0000313|EMBL:CDG70130.1};
GN   Synonyms=LOC100200352 {ECO:0000313|RefSeq:XP_002156706.1};
OS   Hydra vulgaris (Hydra) (Hydra attenuata).
OC   Eukaryota; Metazoa; Cnidaria; Hydrozoa; Hydroidolina; Anthoathecata;
OC   Aplanulata; Hydridae; Hydra.
OX   NCBI_TaxID=6087 {ECO:0000313|EMBL:CDG70130.1};
RN   [1] {ECO:0000313|EMBL:CDG70130.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Whole animals {ECO:0000313|EMBL:CDG70130.1};
RX   PubMed=24065732; DOI=10.1093/gbe/evt142;
RA   Wenger Y., Galliot B.;
RT   "Punctuated emergences of genetic and phenotypic innovations in eumetazoan,
RT   bilaterian, euteleostome, and hominidae ancestors.";
RL   Genome Biol. Evol. 5:1949-1968(2013).
RN   [2] {ECO:0000313|RefSeq:XP_002156706.1}
RP   IDENTIFICATION.
RC   STRAIN=105 {ECO:0000313|RefSeq:XP_002156706.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; HAAD01003898; CDG70130.1; -; mRNA.
DR   RefSeq; XP_002156706.1; XM_002156670.3.
DR   EnsemblMetazoa; XM_002156670.3; XP_002156706.1; LOC100200352.
DR   EnsemblMetazoa; XM_002156670.4; XP_002156706.1; LOC100200352.
DR   GeneID; 100200352; -.
DR   KEGG; hmg:100200352; -.
DR   OrthoDB; 68574at2759; -.
DR   Proteomes; UP000694840; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00155; RasGEF; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   2: Evidence at transcript level;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000694840}.
FT   DOMAIN          549..667
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          687..912
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   REGION          247..273
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          321..355
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        321..349
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   914 AA;  105485 MW;  C334A90A2371A0AC CRC64;
     MISNNKQDLS STNRSTDHLK VNLVHVDGKV KRMQAFIKKI GKNRKTSLGD NEFDKGNHDE
     FEVIESKKEA KTQETLLLQY KKDVNSALTY YKAILKRGVV QKLPGTATAI LESIINAENT
     IESCLEVLFR LKEFEPEKNK VSPLKVSLYR SITALIRLSD NVLFESYTHI NIDTESANKA
     ADNVLTSLEC LYEFVLPKIR KSSLNEELMH CGTSSHSSLD ALDNIPEKDN VDDSAFSDND
     LSINHFGPSL KMPEKKGDPP PKPYLPNGNR NFYGNYDNTQ LRKAISQPDE ISSFKDDLNQ
     VSGRPLSELQ ILDYGRRYSA NNKSSSCKSS KSSISTTSNS SLGSPSKNNK YDTTDEDYAM
     NRRLEAFNKI EMNDSINKDE ISMSSNLVKK IHKYSSRYEI LAKSTLSLFN DEDDNNDSLD
     TSDDSIPPAL PKKKTKHTAD SYLTFVKGYD VIDYNERPSS YYDNLPVPNV HNITEDQFIK
     GDGLPKLPPK KGTYRNCVEP PQAFRTNEGT LKRQRHSIRE SSAVYDEDNI PALDCHDVSK
     FLVFKEEENG PLLCGGTVDA LIVYSTQVED MLFYRAFLAT YRTFVSPTEL ICKLLYRANR
     FQDKGNEETS KSVLRLLVKV MEEMYEELDK SLFDQLRSVV HRLLNLGQLK LAKDLRDKIV
     NYCIKLQVNH MPIYIPRKSD SELFDFKSFL LAQQMCVLDA DYFIKIELPE VLRWGKEQSE
     TLSPNLCRFI GHFNRMSFWV RTLILNEQRQ QEREKIFKKF LKIMRILKRL NNFSAFLAIL
     SALDSSPLRR LEWPKQYIEL LAEDTKLIDS TSAFKTYRKA LSEAKPPCIP YLGLILTDIT
     FIHLGNPQDL PDGKVNFVKR WQQYNILDTV RRFKENLYDF SRDEKILDFF NEYEEHMEEE
     EMWEKSQQIR PRVR
//