ID T2ME94_HYDVU Unreviewed; 350 AA.
AC T2ME94;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=ADP-ribosyl cyclase 2 {ECO:0000313|EMBL:CDG70287.1};
DE SubName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase-like isoform X1 {ECO:0000313|RefSeq:XP_002166775.2};
GN Name=BST1 {ECO:0000313|EMBL:CDG70287.1};
GN Synonyms=LOC100201399 {ECO:0000313|RefSeq:XP_002166775.2};
OS Hydra vulgaris (Hydra) (Hydra attenuata).
OC Eukaryota; Metazoa; Cnidaria; Hydrozoa; Hydroidolina; Anthoathecata;
OC Aplanulata; Hydridae; Hydra.
OX NCBI_TaxID=6087 {ECO:0000313|EMBL:CDG70287.1};
RN [1] {ECO:0000313|EMBL:CDG70287.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Whole animals {ECO:0000313|EMBL:CDG70287.1};
RX PubMed=24065732; DOI=10.1093/gbe/evt142;
RA Wenger Y., Galliot B.;
RT "Punctuated emergences of genetic and phenotypic innovations in eumetazoan,
RT bilaterian, euteleostome, and hominidae ancestors.";
RL Genome Biol. Evol. 5:1949-1968(2013).
RN [2] {ECO:0000313|RefSeq:XP_002166775.2}
RP IDENTIFICATION.
RC STRAIN=105 {ECO:0000313|RefSeq:XP_002166775.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the ADP-ribosyl cyclase family.
CC {ECO:0000256|ARBA:ARBA00005406}.
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DR EMBL; HAAD01004055; CDG70287.1; -; mRNA.
DR RefSeq; XP_002166775.2; XM_002166739.3.
DR EnsemblMetazoa; XM_002166739.3; XP_002166775.2; LOC100201399.
DR EnsemblMetazoa; XM_002166739.4; XP_002166775.2; LOC100201399.
DR GeneID; 100201399; -.
DR KEGG; hmg:100201399; -.
DR OMA; VWDAFEQ; -.
DR OrthoDB; 4265952at2759; -.
DR Proteomes; UP000694840; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProt.
DR GO; GO:0050135; F:NAD(P)+ nucleosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0061809; F:NAD+ nucleotidase, cyclic ADP-ribose generating; IEA:UniProtKB-EC.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR CDD; cd04759; Rib_hydrolase; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR003193; ADP-ribosyl_cyclase.
DR PANTHER; PTHR10912; ADP-RIBOSYL CYCLASE; 1.
DR PANTHER; PTHR10912:SF7; ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE; 1.
DR Pfam; PF02267; Rib_hydrolayse; 1.
DR SUPFAM; SSF52309; N-(deoxy)ribosyltransferase-like; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801,
KW ECO:0000313|RefSeq:XP_002166775.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000694840};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..350
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041199424"
SQ SEQUENCE 350 AA; 40463 MW; B6C64A69CF780179 CRC64;
MFFQILLLQG ILLKDVVMVA PPSLFDTFKS YFSADLNKQI STKGNIDPDF QNSDSDSDWL
INNYANFFKS DVNQKGNQAS INKISEIQKY GTTRHIKEIF LGRCYEYQYK NGVLEENEWN
CENLWNLFFK AFGFKKPCDV TSADYKELLD NIDERIPRDK ALLWSGTREL AHKYSDFLYT
KRFTTLEDTL AGYLLNGLTW CGSDQPPGIN FNQCPWECSI QAPYWSLANQ RFAQKLSGVI
HIVLNGTRQH YTDKKLYPAY MKHRYYLGPY MIPEFNKRNI TMVVIIVAHT LHLKPIESCG
QKTVQMLADD IKAKDIPVVC YDDPSVVKHI LCVDDPMSLE CMQISRGARL
//
