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Database: UniProt/TrEMBL
Entry: U3JBK4_FICAL
LinkDB: U3JBK4_FICAL
Original site: U3JBK4_FICAL 
ID   U3JBK4_FICAL            Unreviewed;       917 AA.
AC   U3JBK4;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   22-NOV-2017, entry version 36.
DE   SubName: Full=Hexokinase 2 {ECO:0000313|Ensembl:ENSFALP00000000158};
GN   Name=HK2 {ECO:0000313|Ensembl:ENSFALP00000000158};
OS   Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae;
OC   Ficedula.
OX   NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000000158, ECO:0000313|Proteomes:UP000016665};
RN   [1] {ECO:0000313|Ensembl:ENSFALP00000000158}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23103876; DOI=10.1038/nature11584;
RA   Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N.,
RA   Kawakami T., Kunstner A., Makinen H., Nadachowska-Brzyska K.,
RA   Qvarnstrom A., Uebbing S., Wolf J.B.;
RT   "The genomic landscape of species divergence in Ficedula
RT   flycatchers.";
RL   Nature 491:756-760(2012).
RN   [2] {ECO:0000313|Ensembl:ENSFALP00000000158}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2013) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the hexokinase family.
CC       {ECO:0000256|SAAS:SAAS00672880}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSFALP00000000158}.
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DR   EMBL; AGTO01021790; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005057993.1; XM_005057936.1.
DR   Ensembl; ENSFALT00000000159; ENSFALP00000000158; ENSFALG00000000141.
DR   GeneID; 101810322; -.
DR   GeneTree; ENSGT00390000017159; -.
DR   OMA; HAIAPVK; -.
DR   OrthoDB; EOG091G08MD; -.
DR   Proteomes; UP000016665; Unplaced.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR   GO; GO:0004396; F:hexokinase activity; IEA:Ensembl.
DR   GO; GO:0008637; P:apoptotic mitochondrial changes; IEA:Ensembl.
DR   GO; GO:0001678; P:cellular glucose homeostasis; IEA:InterPro.
DR   GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl.
DR   GO; GO:0072655; P:establishment of protein localization to mitochondrion; IEA:Ensembl.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:Ensembl.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-KW.
DR   GO; GO:0072656; P:maintenance of protein location in mitochondrion; IEA:Ensembl.
DR   GO; GO:0035795; P:negative regulation of mitochondrial membrane permeability; IEA:Ensembl.
DR   GO; GO:2000378; P:negative regulation of reactive oxygen species metabolic process; IEA:Ensembl.
DR   GO; GO:1904925; P:positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization; IEA:Ensembl.
DR   GO; GO:0046324; P:regulation of glucose import; IEA:Ensembl.
DR   InterPro; IPR001312; Hexokinase.
DR   InterPro; IPR019807; Hexokinase_BS.
DR   InterPro; IPR022673; Hexokinase_C.
DR   InterPro; IPR022672; Hexokinase_N.
DR   PANTHER; PTHR19443; PTHR19443; 4.
DR   Pfam; PF00349; Hexokinase_1; 2.
DR   Pfam; PF03727; Hexokinase_2; 2.
DR   PROSITE; PS00378; HEXOKINASE_1; 2.
DR   PROSITE; PS51748; HEXOKINASE_2; 2.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00672869};
KW   Complete proteome {ECO:0000313|Proteomes:UP000016665};
KW   Glycolysis {ECO:0000256|SAAS:SAAS00672870};
KW   Kinase {ECO:0000256|SAAS:SAAS00672871};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00672883};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW   Transferase {ECO:0000256|SAAS:SAAS00672884}.
FT   DOMAIN       22    219       Hexokinase_1. {ECO:0000259|Pfam:PF00349}.
FT   DOMAIN      225    459       Hexokinase_2. {ECO:0000259|Pfam:PF03727}.
FT   DOMAIN      471    667       Hexokinase_1. {ECO:0000259|Pfam:PF00349}.
FT   DOMAIN      673    907       Hexokinase_2. {ECO:0000259|Pfam:PF03727}.
SQ   SEQUENCE   917 AA;  102454 MW;  04C1538BEF29C6F0 CRC64;
     MIASHLLAYF FTELNHDQTQ KIDKYLYHMR LSDETLLEVS QRFEKEMEKG LGADTNPTAS
     VKMLPTFVRS TPDGTEDGDF LALDLGGTNF RVLRVKVSDN GLRKVEMENQ IYAIPEELMR
     GSGVQLFDHI AECLANFLDK LQIKDKKLPL GFTFSFPCHQ TKLDESILVT WTKGFKCSSV
     EGRDVVSLLR KSIRKRGDFD IDIVAVVNDT VGTMMTCGYD DHNCEVGLIV GTGTNACYME
     EMRHIDLVEG DEGRMCINME WGAFGDDGVL NDIRTEFDRE IDMGSLNPGK QLFEKMISGM
     YMGELVRLIL VKMAKEGLLF GGRLTPDLLT TGHFETRFVS AIEKEKEGLQ KAHEILSKLG
     LEPSHEDCLA TLRICQIVST RSASLCGATL AAVLRRIKDN KGVERLRSTV GVDGSVYKKH
     PHFARRLHKT VRKLLPDCEI RFIRSEDGSG KGAAMVTAVA YRLAAQHKAR QKILEPLKLS
     HEQLLEVKER MRIEMEKGLG KETHAEATVK MLPTYVCSTP DGTEKGDFLA LDLGGTNFRV
     LLVRVRNGMR RGVEMHNKIY SIPVEIMQGT GEELFDHIVH CISDFLEYMG MKGVSLPLGF
     TFSFPCQQNN LDEGILLKWT KGFKATGCEG EDVVGLLKEA IHRREEFDLD VVAVVNDTVG
     TMMTCGYEDP YCEVGLIVGT GSNACYMEEM RNVELVEGDE GRMCVNMEWG AFGDSGCLDD
     IRTEFDVAVD ELSLNPGKQR YEKMISGMYL GEIVRNILMD FTKKGLLFRG RISERLKTRG
     IFETKFLSQI ESDCLALLQV RSILQHLGLE STCDDSIIVK EVCTVVARRA AQLCGAGMAA
     VVDKIRENRG LDFLKITVGV DGTLYKLHPH FSNILHETVK QLSPKCEVTF LQSEDGSGKG
     AALITAVACR IREAGQR
//
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