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Database: UniProt/TrEMBL
Entry: U3QWC9_RALPI
LinkDB: U3QWC9_RALPI
Original site: U3QWC9_RALPI 
ID   U3QWC9_RALPI            Unreviewed;       745 AA.
AC   U3QWC9;
DT   11-DEC-2013, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2013, sequence version 1.
DT   22-NOV-2017, entry version 24.
DE   SubName: Full=Isocitrate dehydrogenase {ECO:0000313|EMBL:AGW94548.1};
DE            EC=1.1.1.42 {ECO:0000313|EMBL:AGW94548.1};
GN   ORFNames=N234_31370 {ECO:0000313|EMBL:AGW94548.1};
OS   Ralstonia pickettii DTP0602.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Ralstonia.
OX   NCBI_TaxID=1366050 {ECO:0000313|EMBL:AGW94548.1, ECO:0000313|Proteomes:UP000016821};
RN   [1] {ECO:0000313|EMBL:AGW94548.1, ECO:0000313|Proteomes:UP000016821}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DTP0602 {ECO:0000313|EMBL:AGW94548.1,
RC   ECO:0000313|Proteomes:UP000016821};
RA   Ohtsubo Y., Fujita N., Nagata Y., Tsuda M., Hatta T.;
RT   "Complete genomic sequence of a trichlorophenol degrader Ralstonia
RT   pickettii DTP0602 (=NBRC 109403).";
RL   Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP006668; AGW94548.1; -; Genomic_DNA.
DR   EnsemblBacteria; AGW94548; AGW94548; N234_31370.
DR   KEGG; rpj:N234_31370; -.
DR   PATRIC; fig|1366050.3.peg.6252; -.
DR   KO; K00031; -.
DR   OrthoDB; POG091H0B3N; -.
DR   Proteomes; UP000016821; Chromosome 2.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   PANTHER; PTHR36999; PTHR36999; 1.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000016821};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Oxidoreductase {ECO:0000313|EMBL:AGW94548.1}.
FT   REGION      134    141       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       352    352       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       551    551       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       555    555       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     147    147       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     550    550       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        257    257       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        422    422       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   745 AA;  81974 MW;  71B0F10C518CB624 CRC64;
     MSIQQPTIIY TLTDEAPLLA TSAFLPIIQT FTKPAGINVT TSDISVAGRI LGEFSEFLTE
     EQRVPDNLAE LGKLTQSPDT NIIKLPNISA SVHQLVSAIR ELQGKGYKVP DYPEDPKTDE
     EKAIQKRYSK CLGSAVNPVL REGNSDRRAP AAVKNYARKH PHSMGEWSMA SRTHVAHMKH
     GDFYHGEKSM TLDKARDVKM ELVTRSGKTI VLKPKVSLQD GEIIDSMFMS KKALCAFYEE
     QFEDARQTGV MLSLHVKATM MKVSHPIVFG HAVKIFYKEA FAKHGALFDE LGVNVNNGLV
     NLYEKIESLP SSKREEIIRD LHACHEHRPE LAMVDSAKGI SNLHAPNDVI VDASMPAMIR
     IGGKMWGADG RPKDTKAVIP ESTFARIYQE IINFCKTNGN FDPTTMGTVP NVGLMAQKAE
     EYGSHDKTFE ITEDGVANIV DLATGEVLLT QNVEQGDIWR MCQVKDAPIR DWVKLAVTRA
     RNSGMPAVFW LDPYRPHEAE LIKKVEAYLK DYDTNGLDIQ IMSQVRAMRY TLERVIRGLD
     TISVTGNILR DYLTDLFPIM ELGTSAKMLS IVPLMAGGGM YETGAGGSAP KHVKQLVEEN
     HLRWDSLGEF LALAVSLEDV GIKTGNAKAK ILAKTLDAAT GKLLDNNKSP SPKTGQLDNR
     GSQFYLAMYW AQELAAQSDD AELAAKFAPL AKTLTDNEQK IVGELAAVQG QPVDIGGYYQ
     PDAAKLSAAM RPSQTLNAAL QTVAA
//
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