ID V4AHI0_LOTGI Unreviewed; 740 AA.
AC V4AHI0;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Histone-lysine N-methyltransferase ASH1L {ECO:0008006|Google:ProtNLM};
GN ORFNames=LOTGIDRAFT_143999 {ECO:0000313|EMBL:ESO96362.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO96362.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO96362.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; KB201470; ESO96362.1; -; Genomic_DNA.
DR RefSeq; XP_009052947.1; XM_009054699.1.
DR AlphaFoldDB; V4AHI0; -.
DR STRING; 225164.V4AHI0; -.
DR EnsemblMetazoa; LotgiT143999; LotgiP143999; LotgiG143999.
DR GeneID; 20234774; -.
DR KEGG; lgi:LOTGIDRAFT_143999; -.
DR CTD; 20234774; -.
DR HOGENOM; CLU_352882_0_0_1; -.
DR OMA; TCEQEEH; -.
DR OrthoDB; 2882778at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0140938; F:histone H3 methyltransferase activity; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:UniProt.
DR CDD; cd04717; BAH_polybromo; 1.
DR CDD; cd15548; PHD_ASH1L; 1.
DR CDD; cd19174; SET_ASH1L; 1.
DR Gene3D; 2.30.30.490; -; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001025; BAH_dom.
DR InterPro; IPR043151; BAH_sf.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR043319; PHD_ASH1L.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46147; HISTONE-LYSINE N-METHYLTRANSFERASE ASH1; 1.
DR PANTHER; PTHR46147:SF3; HISTONE-LYSINE N-METHYLTRANSFERASE ASH1; 1.
DR Pfam; PF01426; BAH; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF20826; PHD_5; 1.
DR Pfam; PF00856; SET; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00439; BAH; 1.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00249; PHD; 1.
DR SMART; SM00508; PostSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51038; BAH; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 1..119
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 127..143
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT DOMAIN 309..379
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 517..654
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT REGION 149..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 681..740
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 708..724
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 740 AA; 86208 MW; 86206BC7DE37F84A CRC64;
MYNTIIIHSC ISQIVSTKFY VVIISGDFIL EYLGEVVSEQ EFRRRMTEDY SKDCHHYCLS
LDSGMVIDGY RMANIGRFVN HSCEPNCEMQ KWTVNGLYRM VLFALRDIDP MEELTYDYNF
DSFNMETQQV CKCGSENCRG VIGGKTQKNN QIKEKLSSTR PVGRPPKDKR KSKYKLKKFK
DKVKPTSANN KLLNHSVIKP MSNRERTYCI KHGVFLIRNV ERTKHKQLKQ DGVEVKETCN
ISTTVNNTDN NNITTVIKPG YQLTQREDRS VKTRLVSRVE DNPELQKRCQ LIKLFNKVYD
TVANYKDEDD NILATPLMNL PNKKKCPDYY KIIDEPVDLT TIRNQIQTGE YETLDSLDKD
VLQLFRNVER YCGRKSDMGR LVLKLRKVYC SAKNEVIPLI DDILSDGQIV SNTPPIAPPE
IDTESIENRA IRDPPDEEEE IIRCLCNVFR DEGLMIQCEK CFIWQHCDCV GATGNEEYYV
CEKCDGRTYD KEIKLVPQPT DGDSENDYYM TLLRDDLQVA IGECVYILRD YKRNSDGTPD
IRPLSDYTNI TPDKLDIFRI ERLWKNKAGE RFADGHPFVR PHETFHEPTR KFFPNELFRL
PTLEIVPVEV MVGTCCVMDL YTYCKGRPKL VKEKDIYICE YRVDKTAHLF YKVVKNWYPI
NTKSYCFNTF KEKLNAKRTY SPHQVPEEYL RRTDKQSSTS KSSTDNSSKN TDKNKTEDKN
SKKSNKTTKI KKRLSVSFSL
//
