ID V4AIR3_LOTGI Unreviewed; 770 AA.
AC V4AIR3;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ESO93356.1};
GN ORFNames=LOTGIDRAFT_189988 {ECO:0000313|EMBL:ESO93356.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO93356.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO93356.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005232, ECO:0000256|RuleBase:RU003801}.
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DR EMBL; KB201931; ESO93356.1; -; Genomic_DNA.
DR RefSeq; XP_009056051.1; XM_009057803.1.
DR AlphaFoldDB; V4AIR3; -.
DR STRING; 225164.V4AIR3; -.
DR EnsemblMetazoa; LotgiT189988; LotgiP189988; LotgiG189988.
DR GeneID; 20244869; -.
DR KEGG; lgi:LOTGIDRAFT_189988; -.
DR CTD; 20244869; -.
DR HOGENOM; CLU_013513_2_1_1; -.
DR OMA; PWAQMRQ; -.
DR OrthoDB; 1429709at2759; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004095; F:carnitine O-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR Gene3D; 6.10.250.1760; -; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR InterPro; IPR000542; Carn_acyl_trans.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR039551; Cho/carn_acyl_trans.
DR InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR InterPro; IPR032476; CPT_N.
DR PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR22589:SF31; CARNITINE O-PALMITOYLTRANSFERASE; 1.
DR Pfam; PF00755; Carn_acyltransf; 1.
DR Pfam; PF16484; CPT_N; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR PROSITE; PS00439; ACYLTRANSF_C_1; 1.
DR PROSITE; PS00440; ACYLTRANSF_C_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000256|RuleBase:RU003801};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003801};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 54..77
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 103..126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..47
FT /note="Carnitine O-palmitoyltransferase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16484"
FT DOMAIN 175..758
FT /note="Choline/carnitine acyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00755"
FT ACT_SITE 475
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ SEQUENCE 770 AA; 87388 MW; C3F7A3790BB068ED CRC64;
MAEAHAAVAF SFSVTPDGVN VAVNHEALWA VFHSGVLSWN RKIHRIKNSF HNGIYPASAM
SLLFTISIVL ALCLGGFDVS YGSIKYIQTH FPGISYANDT VNFVISSVIF STILWITVIN
VIKYILRLLF NYQNWMYEVR GKKVSWQTKL WVVLVKSFSG RHPKLYSYQA SLPKLPVPGV
EDTMNRYLLS VRPLLDDEKY NRMKGLAEEF KNGIGNKLQR YLILKSWWAS NYVSDWWEEY
VYLRGRAPIM INSNFYGIDA VFLKPTHRPL SRAGNIIYSM LKFRREVDRE ELEPIILNKT
VPLCSSQYER QFNTTRIPGV ETDQLIQYHD SSHIAVYHKG RYYKVYIRNK GVLLTPCEIE
YTLQKIVDDD SVPSPGEKEL AALTAGERVA WAKARAEYFS KGKNKASLHA IEKAAFCVTL
DEDAQEFDLN VEEKPELLDV YGQAMLHGKG YDRWFDKSFT LVVCANGRIG FNAEHSWADA
PIMAHLWEYA ISEDNLILGY TEDGHCKGEL GPTPPPHPIR LEWDIPKPCQ SIIEEQLQVA
KQLISDVDLH LMVHTAFGKG LIKQCKVSPD AFLQIALQLT YYRTAGKFCL TYESSMTRLY
REGRTETVRS CTVDSCEFVK SMDDPNCTNE ERIAKFQRAS ESHQQGYRDA MTGKGIDRHL
FCLYVVSKYL GVDSPFLAEV LSEPWRLSTS QTPHTQTNRI DLVKYPKQIC AGGGFGPVAD
DGYGVSYIVA GEDTLFFHIS SKKSCPTTSS KKFGAGINKA LQDLKNLFGK
//
