ID V4BRT3_LOTGI Unreviewed; 4455 AA.
AC V4BRT3;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=AAA+ ATPase domain-containing protein {ECO:0000259|SMART:SM00382};
DE Flags: Fragment;
GN ORFNames=LOTGIDRAFT_122204 {ECO:0000313|EMBL:ESO91629.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO91629.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO91629.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; KB202237; ESO91629.1; -; Genomic_DNA.
DR RefSeq; XP_009057694.1; XM_009059446.1.
DR STRING; 225164.V4BRT3; -.
DR EnsemblMetazoa; LotgiT122204; LotgiP122204; LotgiG122204.
DR GeneID; 20232077; -.
DR KEGG; lgi:LOTGIDRAFT_122204; -.
DR CTD; 20232077; -.
DR HOGENOM; CLU_000038_9_1_1; -.
DR OMA; LHCHFGE; -.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF343; DYNEIN AXONEMAL HEAVY CHAIN 10; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746}.
FT DOMAIN 1799..1935
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2088..2236
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2430..2581
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 82..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3245..3307
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 82..106
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ESO91629.1"
SQ SEQUENCE 4455 AA; 512579 MW; 5D52F4EFCAE16073 CRC64;
VFRTYLFMCY EHLPEEVSDL NSVYFLRNTP GMVPLPNSVE EADEMLPGYF EFGVLNGHSL
VMLEQIITQV YMPLLSFNQH KNAGSRQDTG TTQSSESSTP EESSKINVAE SRAKALLRDE
FLISMQKFSA SINRTLQQIE GEVRLEIPEL EVGSNIDEIL ANNDLMWQIR EICGEWRKQV
QEALDSQLKK GHHSNGPLAE IDFWRERNAS LSALSEQLKI PKVKQFLKIY SQVDSDFDDL
ISELTKYDTE AKDNVRFLST LERHFKNIAH GATFQVVIET IPSMMNALRM VWIISRHYNK
DERMVPLMER IAWELAERVA KVIDVREIFD DGTDEVKTKT AEASKMLTTW RESYFEVRGM
IEASGRDQRW EFDRKKLFER TDYMTSICDD LHEIAQVLEE FYNIFGPELK SVTGDPKRIE
DVVYRVDALV FPIQQITFDP FSQKEQHQWH RLKANFKKEV EEIEGEAKMF IDESFKTLRS
AEGAFDMLLN FKHIRSREAI NNQMMQKFKD ILNQYGKEVD TMDHLFREFQ DSPPLNKNNP
PTSGTIFWER SLFHRIKHTI IRFQTMDEMM LTADGKDTRA KYLKVGKDMK RFEDIKYEQW
RDHVEQILPS LLRRNLLLKP HHAQSGSLFE IKYLVDFDPQ LHEIIAETKY MEQLGFSVPE
LARNVALQEE KYIKYVDGLQ NMLSRYHRLL GSLDPAEVTL LDDHMKDLRR VLRPGAKRLN
WNSLGINDYM SKCQSAIAKF ESLVNQIQKN ARDINQRLSM IEHSNMFKHL PPKYDDILPS
CKEFFEHIES ERHRDFELLA RKYRAIGPLL TKMEGLVVHT NTGKSPKLSQ YYAYWEKRVY
ESLTKLVIRN LKSFHHALIG DKALFQVETL LVAPDVVLHP HTNEINKLIL QCVRDGVEGT
KLFVRWMNGT CIECPPQKVE GEDEPHVFSF FSDISNNSEI LEVCSSIHQS VRRTLTSLAR
YLIRWKKYKS IWKVDKQPIA DKWFSKGPSV VEFDDKLQYY YKTIDEVAAL PTVKEQDFIK
LHMGPLATDV KKHAKQWIDC LGNILHTSAK ESLDQLWNMM DDKSDDLDQS PGVLEDLKSV
LSTISDIKTM SLEVETQMRD IQERYRTLAM YNVEVPEAER DLQARLPEIW ADLVLKSKNV
DASLIVVKKK FTEITQDEIK EFRKNLEKFA ETFKIEGPGA VGNDLDLGLE KMKKFRQEVA
QYEGQRNELA NAEKLFDLPI TMYPDLVQVT KDMKGLEMIY ALYEEQLAAR EQWAETLWAN
LNVQILQDGI EGFLKTLRKF PKDVRSLPVA RTLEEKMKEF RDSLPLFVDL KHEALRERHW
KDLMSKTGQK FDINPETFTL ANVFAMELHR FQETIGEIVT CASKEMGIEK GVREVEETWS
NMKFTVQAYM KGTSNRGYIL GAVDDILQIL DDSAMNLQSM SASRFVGPFL NSVQNWEKGL
SLISEVLDVW MVVQRKWMYL EGIFIGGDIR SQLPEEAKKF DQIDKTFKKI MNDTFKVPTI
KTACHAQNRL ADLQNLSSGL EKCQKSLNDY LDSKRNAFPR FFFISDDELL SILGSSDPEC
VQEHMIKMFD NISSLKFQKG ANNEMVVTAM VSAEGEMMDY RTTVSAEGRV EDWMTSVLDE
MRRSNRLITK EAIFTYCNNI KRVDWMMQYQ GMVCLAGNQV WWTWEVEDVF RKVKKGKKTA
LKDYAKQLHG QIDDLVVKVR SPLTKNDRLK FNSVLIIDVH ARDIIDGFVR DSIMDAREFE
WESQLRFYWE KEPDELLIRQ CTGDFGYGYE YMGLNGRLVI TPLTDRIYLT LTQALSMNLG
GAPAGPAGTG KTETTKDLAK ALGLLCVVTN CGEGMDFKAV GKIFSGLCQC GAWGCFDEFN
RIDVSVLSVI STQLKTIQNG LLLKLKRFHF EGQEINLDSR VGIFITMNPG YAGRTELPES
VKALFRPVVV IVPDLQQICE IMLFSEGFLL AKVLAKKMTV LYKLAKEQLS KQYHYDFGLR
ALKSVLVMAG ELKRGSPDLS EDVVLMRALR DMNLPKFVFE DVPLFLGLIG DLFPGLDCPR
VRYPNFNDAV EAVIQENNYI ELPQQVRDFS LIGFRVDKVV QMYETMLTRH TTMIVGPTGG
GKSVVINTLS QAQSRLGIQT KLFTINPKDR SVIELYGILD PATRDWTDGL LSNIFREINK
PTDKNEKKYI VFDGDVDALW VENMNSVMDD NRLMTLANGE RIRLQKHCAL LFEVYDLQYA
SPATISRCGM VYVDPKNLGY KPYWDKWVNV RNCGKSEKDD LNRLYEKYVP NLIDMVVEGV
VEGRQQEKIK TIVPLTNLNM VTQLSMMLNA LLTKEIPEFE ELEALFLQAL YWSIGAGLLE
AGRTKFDAYV KYLASLTMIT DDDQQAGPGE LPQSSLLYEY YWDGEQKKWI PWAKLVPKYI
HNPEVKFNEI LVPTIDTVRT TWLIKLMVEI KRPVVLIGET GTSKSATTAN FLRGMDQDAH
LLLNMNFSSR TTSLDVQRNL EANVEKRTKD TYGPPMGKRL IIFVDDMNMP QVDTYGTQQP
IALLKLLLER GGIYDRGKDL NWKNLKDIGY IAAMGKAGGG RNETDPRFVS LFSVFNMTFP
SEESLYSIYY SILKGHTQAF PQEIQDIVSS ITKMTMTLYG MIVKELPPTP SKFHYIFNLR
DLSRIYNGLC LTTPDRFQKP EQFLRVWRNE CLRVIGDRLI NEQDKEIVNV TMKGLLEENF
NSSTEFVLRD PCLFGDYRTA LEESEPRLYE DVQDYDASKA LFQEILEEYN ESHTPMNLVL
FDDALEHLTR IHRVLRMDRG HSLLVGVGGS GKQSLCRLAS FTAGCEVFEI TLSRGYSESS
FRDDLKVLYN MLGTENKKVS FLFTDQHVVE EGFLELINNM LTSGMVPALY ADDEKEGIIS
GIRDEAIKNG AAHARESIWQ YFVNKCANNL HVVMAMSPVG DTLRTRCRNF PGMVNNASID
WFFPWPEQAL YAVASVFISP ENNLIPDEHR ENLVTHIVLV HTSVGHYSKM FLQRLRRNNY
VTPKNYLDFI NTYLKLLEEK DQYILSQCER LAGGLSKIAD ASDMLAVLSD KLAVQEVAVR
EKTAACQELL EEIAIGTKQA TEKKEMAQKK GKEIEEQNKI IVVEKKEAED ALAEALPALE
MARIALEDLE KSDVTEIRSF AKPPKAVQTV CECIVVMRGI REVSWKSAKG MMSEANFLKS
LTEMDVDGIT PKQTAAVKGL LKEMDTTPAD MKAVSRAGAG LLKFVEAVMG YCSVAREIKP
KREKVAKLER SYHQAKRDLD KITKEISALE SELSKLNQKY EEAMSEKKAL QEEAEIMERR
LRAADKLISG LGSENVRWVK NLEELKNKRV RLLGDCLLNS AFLSYVGAFS WEFRNDLVYQ
EWKNDLKERE IPLSDPFKLE DLLTNDVEIS KWTSEGLPPD DLSIQNGILT TRASRFPMCI
DPQQQALKWI KKKEEANNLK VCTFNDPDFL KQLELAIKYG FPFLFQDVDE YIDPVIDNVL
ERNIKGGQGR EFVMLGDKEV DYDPNFRLYL NTKLANPKYG PNVFGKSMVI NYTVTLKGLE
DQLLSVIVKY ERKELEEQRE RLIQETSVNK RLLKDLEDSL LRELATSQGN MLDNVELVET
LEETKTKASE VSIKLKQGAE TAIDIEKLRD GYRPAAKRGA ILFFVLAEMS LVNTMYQYSL
ASYLDVFEFS LKKSLPDSIL HKRLRNIMET LTHNVYNYGC TGIFEKHKLL FSLQITIKLE
QDQSHLGQEE LDFFIKGNIA LEKSKRKKPF GWLPDEGWED CTRLATEFSD KFGTLLDDIE
KNENAWKEWY DHDTPESQPF PGRYEQSLAA FQRLMLLRCF RVDRIYRAVT EYITSVMGEK
YVTPPIISFE AIFEQSTPMS PIVFILSPGS DPASDLMKLA ERLEFGTNKL KYLSMGQGQE
QVALQLLETA IARGQWLMLQ NCHLLVNWLL ELEKHLEKLN KPHPDFRLWL TTDPTPRFPI
GILQRSLKVV TEPPNGLKLN LRSTYHKIPA TALSECPHPA FSSLIFVLAF FHAVVQERRK
YGKIGWNVSY DFNESDFRVC MQILNTYLTK STDQGDSKIP WASLKYLIGE VMYGGRAIDD
FDRRVLRTYM DEYMGDFIFD TFQPFHFYHN EEVDYKIPEP GPRDNYIDFL ESLPLSNTPE
VFGLHPNAEI GYYTQAARDM WSHLVELQPQ TGESGGGISR EEFIDKIATD VLNKLPEEFD
LDKIRKKFGI DISPTTVVLL QELERFDKLI IRMRRSLTTL QRALAGEVGM SSELDEVARA
LFNGQIPSIW RRLAPDTLKS LGNWMIHFER RFKQYNFWVN ESEPPVMWLS GLHIPESYLT
ALVQATCRKN GWPLDKSTLY TSVTQYQTAD DVTERAHSGC FVTGLYLEGA AWDRKEMCLI
RQKPKQLIQE LPVLKIIPIE SHRLKLQNTL RTPVYVTSQR RNAMGVGLVF EADLATTEHI
SHWVLQGACL ILNTD
//
