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Database: UniProt/TrEMBL
Entry: V5IP39_NEUCR
LinkDB: V5IP39_NEUCR
Original site: V5IP39_NEUCR 
ID   V5IP39_NEUCR            Unreviewed;       489 AA.
AC   V5IP39;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   07-JUN-2017, entry version 32.
DE   RecName: Full=Phosphotransferase {ECO:0000256|RuleBase:RU362007};
DE            EC=2.7.1.- {ECO:0000256|RuleBase:RU362007};
GN   Name=emp-1 {ECO:0000313|EMBL:ESA43908.1};
GN   ORFNames=NCU02542 {ECO:0000313|EMBL:ESA43908.1};
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM
OS   1257 / FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Sordariomycetidae; Sordariales; Sordariaceae;
OC   Neurospora.
OX   NCBI_TaxID=367110 {ECO:0000313|EMBL:ESA43908.1, ECO:0000313|Proteomes:UP000001805};
RN   [1] {ECO:0000313|EMBL:ESA43908.1, ECO:0000313|Proteomes:UP000001805}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC   {ECO:0000313|Proteomes:UP000001805};
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D., FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A.,
RA   Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L.,
RA   Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes W., Staben C.,
RA   Marcotte E., Greenberg D., Roy A., Foley K., Naylor J.,
RA   Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M.,
RA   Mauceli E., Bielke C., Rudd S., Frishman D., Krystofova S.,
RA   Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C.,
RA   Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M.,
RA   Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- SIMILARITY: Belongs to the hexokinase family.
CC       {ECO:0000256|RuleBase:RU362007, ECO:0000256|SAAS:SAAS00672880}.
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DR   EMBL; CM002236; ESA43908.1; -; Genomic_DNA.
DR   RefSeq; XP_011392961.1; XM_011394659.1.
DR   ProteinModelPortal; V5IP39; -.
DR   EnsemblFungi; ESA43908; ESA43908; NCU02542.
DR   GeneID; 3881807; -.
DR   KEGG; ncr:NCU02542; -.
DR   EuPathDB; FungiDB:NCU02542; -.
DR   KO; K00844; -.
DR   OrthoDB; EOG092C2JW4; -.
DR   Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR   GO; GO:0004396; F:hexokinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001678; P:cellular glucose homeostasis; IEA:InterPro.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-KW.
DR   InterPro; IPR001312; Hexokinase.
DR   InterPro; IPR019807; Hexokinase_BS.
DR   InterPro; IPR022673; Hexokinase_C.
DR   InterPro; IPR022672; Hexokinase_N.
DR   PANTHER; PTHR19443; PTHR19443; 1.
DR   Pfam; PF00349; Hexokinase_1; 1.
DR   Pfam; PF03727; Hexokinase_2; 1.
DR   PROSITE; PS00378; HEXOKINASE_1; 1.
DR   PROSITE; PS51748; HEXOKINASE_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU362007,
KW   ECO:0000256|SAAS:SAAS00672869};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001805};
KW   Glycolysis {ECO:0000256|RuleBase:RU362007,
KW   ECO:0000256|SAAS:SAAS00672870};
KW   Kinase {ECO:0000256|RuleBase:RU362007, ECO:0000256|SAAS:SAAS00672871,
KW   ECO:0000313|EMBL:ESA43908.1};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU362007,
KW   ECO:0000256|SAAS:SAAS00672883};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001805};
KW   Transferase {ECO:0000256|RuleBase:RU362007,
KW   ECO:0000256|SAAS:SAAS00672884}.
FT   DOMAIN       17    212       Hexokinase_1. {ECO:0000259|Pfam:PF00349}.
FT   DOMAIN      218    461       Hexokinase_2. {ECO:0000259|Pfam:PF03727}.
SQ   SEQUENCE   489 AA;  54176 MW;  DA94335EDBC782FA CRC64;
     MASGTLDNLP KDLRNEIEHL ERLFTVDGAK LKEVTNHFVH ELEKGLSVQG GSIPMNPTWV
     MSFPDGNETG TYLALDMGGT NLRVCQVTLT ETKSEFDIIQ SKYRMPEELK TGDAEELWEY
     IADCLMQFIE THHGDPTKLD ALPLGFTFSY PATQNYIDEG ILQRWTKGFD IAGVEGHNVV
     PMFEAALQRR GVPIKLTALI NDTTGTLIAS AYTDPKMRIG CIFGTGCNAA YMENCGSIPK
     LAHMNLPPDM PMAINCEWGA FDNEHKVLPR TPYDVIIDKD SPRPGQQSFE KMVAGLYLGE
     IFRLVLVDLH DNQEIKIFPG QDIAKLRKAY SLDSSFLSLI EEDPFENLSE TFELFQTKLG
     LTPTGPELEL IRRTAELIGT RAARLSACGV AAISKKKGYK QCHVGADGSV FNKYPNFKAR
     GAQALREILD WPEKADPKED DPIEILAAED GSGVGAALIA ALTMQRIKQG NMHGILHPEN
     FRTTEPLPA
//
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