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Database: UniProt/TrEMBL
Entry: V5PPP5_9BURK
LinkDB: V5PPP5_9BURK
Original site: V5PPP5_9BURK 
ID   V5PPP5_9BURK            Unreviewed;       746 AA.
AC   V5PPP5;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   07-JUN-2017, entry version 20.
DE   SubName: Full=Isocitrate dehydrogenase {ECO:0000313|EMBL:AHB05227.1};
DE            EC=1.1.1.42 {ECO:0000313|EMBL:AHB05227.1};
GN   ORFNames=U875_07315 {ECO:0000313|EMBL:AHB05227.1};
OS   Pandoraea pnomenusa 3kgm.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Pandoraea.
OX   NCBI_TaxID=1416914 {ECO:0000313|EMBL:AHB05227.1, ECO:0000313|Proteomes:UP000018768};
RN   [1] {ECO:0000313|EMBL:AHB05227.1, ECO:0000313|Proteomes:UP000018768}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3kgm {ECO:0000313|EMBL:AHB05227.1};
RX   PubMed=24812228;
RA   Chan K.G., Yin W.F., Goh S.Y.;
RT   "Complete Genome Sequence of Pandoraea pnomenusa 3kgm, a Quorum-
RT   Sensing Strain Isolated from a Former Landfill Site.";
RL   Genome Announc. 2:e00427-14(2014).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP006900; AHB05227.1; -; Genomic_DNA.
DR   RefSeq; WP_023595151.1; NC_022904.2.
DR   EnsemblBacteria; AHB05227; AHB05227; U875_07315.
DR   KEGG; ppk:U875_07315; -.
DR   PATRIC; fig|1416914.3.peg.1472; -.
DR   KO; K00031; -.
DR   BioCyc; PPNO1416914:G13BI-1440-MONOMER; -.
DR   Proteomes; UP000018768; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000018768};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Oxidoreductase {ECO:0000313|EMBL:AHB05227.1}.
FT   REGION      134    141       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       352    352       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       551    551       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       555    555       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     147    147       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     550    550       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        257    257       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        422    422       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   746 AA;  82646 MW;  6076027291E9A1C5 CRC64;
     MSTQQSSIIY TLTDEAPLLA TGAFLPIIRT FTAPAGVAIE TSDISVAGRI LGEFPEFLTE
     EQRVPDNLAE LGRLTQDPDT NIIKLPNISA SVFQLQSAIK ELQSKGYKVP DYPEDPKTDE
     EKAIQKRYSK CLGSAVNPVL REGNSDRRAP LAVKNYAKKH PHSMGEWSMA SRTHVAHMKH
     GDFYHGEKSM TIDKACDVRM ELVTKSGKTI VLKPKVSLLD GEIIDSMFMS KKALCEFYEE
     QMEDARKTGV MFSLHVKATM MKVSHPIVFG HAVKIFYKEA FEKHGKLFDE LGVNVNNGLV
     NLYEKIEALP STQREEIIRD LHACHEHRPE LAMVDSAKGI SNLHAPNDVI VDASMPAMIR
     LGGKMWGADG RPKDTKAVIP ESTFARIYQE IINFCKTNGA FDPTTMGTVP NVGLMAQKAE
     EYGSHDKTFE IVEDGVANIV NIATGEVLLS QNVEAGDIWR MCQVKDAPIR DWVKLAVNRV
     RNSGMPAVFW LDPYRPHEAE LIKKVETYLK DHDTTGLDIQ IMSQVRAMRY TLERVIRGLD
     TISVTGNILR DYLTDLFPIM ELGTSAKMLS IVPLMAGGGM YETGAGGSAP KHVKQLVEEN
     HLRWDSLGEF LALAVSLEDL GIKTGNNRAK ILARTLDAAT GKLLDNNKGP SPKTGELDNR
     GSQFYLSMYW AQELAEQTDD AELAQRFAPL AKRLAENEKT IVAELAEVQG KPADIGGYYK
     PDFDKLEQVM RPSKTFNAAL ASVATA
//
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