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Database: UniProt/TrEMBL
Entry: V5UA69_9BURK
LinkDB: V5UA69_9BURK
Original site: V5UA69_9BURK 
ID   V5UA69_9BURK            Unreviewed;       746 AA.
AC   V5UA69;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   22-NOV-2017, entry version 23.
DE   SubName: Full=Isocitrate dehydrogenase {ECO:0000313|EMBL:AHB74400.1};
DE            EC=1.1.1.42 {ECO:0000313|EMBL:AHB74400.1};
GN   ORFNames=A6P55_03525 {ECO:0000313|EMBL:ANC43460.1}, X636_02265
GN   {ECO:0000313|EMBL:AHB74400.1};
OS   Pandoraea pnomenusa.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Pandoraea.
OX   NCBI_TaxID=93220 {ECO:0000313|EMBL:AHB74400.1, ECO:0000313|Proteomes:UP000018548};
RN   [1] {ECO:0000313|EMBL:AHB74400.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=RB-44 {ECO:0000313|EMBL:AHB74400.1};
RA   Robson E.H.-J.;
RL   Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AHB74400.1, ECO:0000313|Proteomes:UP000018548}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RB-44 {ECO:0000313|EMBL:AHB74400.1,
RC   ECO:0000313|Proteomes:UP000018548};
RX   PubMed=24699956;
RA   Ee R., Lim Y.L., Yin W.F., Chan K.G.;
RT   "De Novo Assembly of the Quorum-Sensing Pandoraea sp. Strain RB-44
RT   Complete Genome Sequence Using PacBio Single-Molecule Real-Time
RT   Sequencing Technology.";
RL   Genome Announc. 2:e00245-14(2014).
RN   [3] {ECO:0000313|EMBL:ANC43460.1, ECO:0000313|Proteomes:UP000076792}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MCB032 {ECO:0000313|EMBL:ANC43460.1,
RC   ECO:0000313|Proteomes:UP000076792};
RA   Chao H.-J., Zhou N.-Y.;
RT   "Complete Genome Sequence of a Chlorobenzene Degrader, Pandoraea sp.
RT   MCB032.";
RL   Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP006938; AHB74400.1; -; Genomic_DNA.
DR   EMBL; CP015371; ANC43460.1; -; Genomic_DNA.
DR   RefSeq; WP_023871811.1; NZ_CP015371.1.
DR   EnsemblBacteria; AHB74400; AHB74400; X636_02265.
DR   EnsemblBacteria; ANC43460; ANC43460; A6P55_03525.
DR   KEGG; ppno:DA70_24380; -.
DR   KEGG; prb:X636_02265; -.
DR   PATRIC; fig|1380774.3.peg.451; -.
DR   KO; K00031; -.
DR   Proteomes; UP000018548; Chromosome.
DR   Proteomes; UP000076792; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   PANTHER; PTHR36999; PTHR36999; 1.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000018548,
KW   ECO:0000313|Proteomes:UP000076792};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Oxidoreductase {ECO:0000313|EMBL:AHB74400.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018548}.
FT   REGION      134    141       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       352    352       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       551    551       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       555    555       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     147    147       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     550    550       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        257    257       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        422    422       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   746 AA;  82659 MW;  C45B291E84004E5E CRC64;
     MSTQQSSIIY TLTDEAPLLA TGAFLPIIRT FTAPAGVAIE TSDISVAGRI LGEFPEFLTE
     EQRVPDNLAE LGRLTQDPDT NIIKLPNISA SVFQLQSAIK ELQSKGYKVP DYPEDPKTDE
     EKAIQKRYSK CLGSAVNPVL REGNSDRRAP LAVKNYAKKH PHSMGEWSMA SRTHVAHMKH
     GDFYHGEKSM TIDKACDVRM ELVTKSGKTI VLKPKVSLLD GEIIDSMFMS KKALCEFYEE
     QMEDARKTGV MFSLHVKATM MKVSHPIVFG HAVKIFYKEA FEKHGKLFDE LGVNVNNGLV
     NLYEKIEALP STQREEIIRD LHACHEHRPE LAMVDSAKGI SNLHAPNDVI VDASMPAMIR
     LGGKMWGADG RPKDTKAVIP ESTFARIYQE IINFCKTNGA FDPTTMGTVP NVGLMAQKAE
     EYGSHDKTFE IVEDGVANIV NIATGEVLLS QNVEAGDIWR MCQVKDAPIR DWVKLAVNRV
     RNSGMPAVFW LDPYRPHEAE LIKKVETYLK DHDTTGLDIQ IMSQVRAMRY TLERVIRGLD
     TISVTGNILR DYLTDLFPIM ELGTSAKMLS IVPLMAGGGM YETGAGGSAP KHVKQLVEEN
     HLRWDSLGEF LALAVSLEDL GIKTGNNRAK ILAKTLDAAT GKLLDNNKGP SPKTGELDNR
     GSQFYLSMYW AQELAEQKED AELAQRFAPL AKRLAENEKT IVAELAEVQG KPADIGGYYK
     PDFDKLEQVM RPSKTFNAAL ASVATA
//
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