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Database: UniProt/TrEMBL
Entry: V5XBX5_MYCNE
LinkDB: V5XBX5_MYCNE
Original site: V5XBX5_MYCNE 
ID   V5XBX5_MYCNE            Unreviewed;       506 AA.
AC   V5XBX5;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   25-OCT-2017, entry version 25.
DE   RecName: Full=Probable DNA ligase {ECO:0000256|HAMAP-Rule:MF_00407};
DE            EC=6.5.1.1 {ECO:0000256|HAMAP-Rule:MF_00407};
DE   AltName: Full=Polydeoxyribonucleotide synthase [ATP] {ECO:0000256|HAMAP-Rule:MF_00407};
GN   Name=ligB {ECO:0000313|EMBL:AHC24914.1};
GN   Synonyms=lig {ECO:0000256|HAMAP-Rule:MF_00407};
GN   ORFNames=D174_10145 {ECO:0000313|EMBL:AHC24914.1};
OS   Mycobacterium neoaurum VKM Ac-1815D.
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=700508 {ECO:0000313|EMBL:AHC24914.1, ECO:0000313|Proteomes:UP000018763};
RN   [1] {ECO:0000313|EMBL:AHC24914.1, ECO:0000313|Proteomes:UP000018763}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VKM Ac-1815D {ECO:0000313|EMBL:AHC24914.1};
RX   PubMed=24435872;
RA   Shtratnikova V.Y., Bragin E.Y., Dovbnya D.V., Pekov Y.A.,
RA   Schelkunov M.I., Strizhov N., Ivashina T.V., Ashapkin V.V.,
RA   Donova M.V.;
RT   "Complete Genome Sequence of Sterol-Transforming Mycobacterium
RT   neoaurum Strain VKM Ac-1815D.";
RL   Genome Announc. 2:e01177-13(2014).
CC   -!- FUNCTION: DNA ligase that seals nicks in double-stranded DNA
CC       during DNA replication, DNA recombination and DNA repair.
CC       {ECO:0000256|HAMAP-Rule:MF_00407}.
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000256|HAMAP-Rule:MF_00407,
CC       ECO:0000256|RuleBase:RU000617}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00407};
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|HAMAP-Rule:MF_00407, ECO:0000256|RuleBase:RU004196}.
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DR   EMBL; CP006936; AHC24914.1; -; Genomic_DNA.
DR   RefSeq; WP_019514537.1; NC_023036.2.
DR   EnsemblBacteria; AHC24914; AHC24914; D174_10145.
DR   KEGG; mne:D174_10145; -.
DR   KO; K10747; -.
DR   Proteomes; UP000018763; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.3260.10; -; 2.
DR   HAMAP; MF_00407; DNA_ligase; 1.
DR   InterPro; IPR022865; DNA_ligae_ATP-dep_bac/arc.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   SUPFAM; SSF117018; SSF117018; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS00333; DNA_LIGASE_A2; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00407,
KW   ECO:0000256|RuleBase:RU000617};
KW   Cell cycle {ECO:0000256|HAMAP-Rule:MF_00407};
KW   Cell division {ECO:0000256|HAMAP-Rule:MF_00407};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018763};
KW   DNA damage {ECO:0000256|HAMAP-Rule:MF_00407,
KW   ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|HAMAP-Rule:MF_00407,
KW   ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|HAMAP-Rule:MF_00407,
KW   ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00407,
KW   ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|HAMAP-Rule:MF_00407,
KW   ECO:0000256|RuleBase:RU000617, ECO:0000313|EMBL:AHC24914.1};
KW   Magnesium {ECO:0000256|HAMAP-Rule:MF_00407};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_00407};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00407,
KW   ECO:0000256|RuleBase:RU000617};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018763}.
FT   DOMAIN      283    407       DNA_LIGASE_A3. {ECO:0000259|PROSITE:
FT                                PS50160}.
FT   ACT_SITE    209    209       N6-AMP-lysine intermediate.
FT                                {ECO:0000256|HAMAP-Rule:MF_00407}.
FT   BINDING     207    207       ATP. {ECO:0000256|HAMAP-Rule:MF_00407}.
FT   BINDING     214    214       ATP. {ECO:0000256|HAMAP-Rule:MF_00407}.
FT   BINDING     229    229       ATP. {ECO:0000256|HAMAP-Rule:MF_00407}.
FT   BINDING     258    258       ATP. {ECO:0000256|HAMAP-Rule:MF_00407}.
FT   BINDING     295    295       ATP. {ECO:0000256|HAMAP-Rule:MF_00407}.
FT   BINDING     367    367       ATP. {ECO:0000256|HAMAP-Rule:MF_00407}.
FT   BINDING     373    373       ATP. {ECO:0000256|HAMAP-Rule:MF_00407}.
SQ   SEQUENCE   506 AA;  53941 MW;  C3F9FEC27B903F6C CRC64;
     MQLAEIAAAS DDIGATSSRT AKVGLVAAAL RRVDPDEISV VVTWLSGELP QRQIGVGWAG
     LRDLPPPAGD ATLTVAAVHA MLTEIKDIAG KGSKGRRAQR VLDLFAAATE TEQQFLRRLL
     SGELRQGALA GVMADAVAKA AGLPAAAVRR AAMLAGDLSA VAVSAITDGD IGRFTLRVGR
     PVSPMLAQTA TGVAEALDKL DGEAAFETKL DGARVQIHRA GDRVTIYTRT LDDVTERLPE
     VVDAALALPV TDLIADAEAI ALRPDGRPHR FQVTASRFGS RSAAARAEPL SVFFFDLLHR
     DGVDLLDLPL TDRMAALDEV VPAAQRMQRL VTTDPAAAHA FLETTLAAGH EGVMAKAPRA
     PYEAGRRGSG WLKVKPVHTL DLVVLAVEWG SGRRTGTLSN IHLGARDPDT GEFVMLGKTF
     KGMTDEMLAW QTRRFTELAV EGTDGGVVRV RPEQVVEIAI DGVQASSRYP AGMALRFARV
     VRYRDDKPAA QADTVHTVRE LFERSG
//
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