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Database: UniProt/TrEMBL
Entry: W2SHD2_NECAM
LinkDB: W2SHD2_NECAM
Original site: W2SHD2_NECAM 
ID   W2SHD2_NECAM            Unreviewed;       788 AA.
AC   W2SHD2;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   22-NOV-2017, entry version 17.
DE   RecName: Full=Histone deacetylase {ECO:0000256|SAAS:SAAS00894283};
DE            EC=3.5.1.98 {ECO:0000256|SAAS:SAAS00894283};
GN   ORFNames=NECAME_01169 {ECO:0000313|EMBL:ETN69059.1};
OS   Necator americanus (Human hookworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Strongylida; Ancylostomatoidea; Ancylostomatidae; Bunostominae;
OC   Necator.
OX   NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN69059.1, ECO:0000313|Proteomes:UP000053676};
RN   [1] {ECO:0000313|Proteomes:UP000053676}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24441737; DOI=10.1038/ng.2875;
RA   Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K.,
RA   Martin J., Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V.,
RA   Minx P., Warren W.C., Wang Q., Zhan B., Hotez P.J., Sternberg P.W.,
RA   Dougall A., Gaze S.T., Mulvenna J., Sotillo J., Ranganathan S.,
RA   Rabelo E.M., Wilson R.K., Felgner P.L., Bethony J., Hawdon J.M.,
RA   Gasser R.B., Loukas A., Mitreva M.;
RT   "Genome of the human hookworm Necator americanus.";
RL   Nat. Genet. 46:261-269(2014).
CC   -!- CATALYTIC ACTIVITY: Hydrolysis of an N(6)-acetyl-lysine residue of
CC       a histone to yield a deacetylated histone.
CC       {ECO:0000256|SAAS:SAAS00894227}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00894298}.
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DR   EMBL; KI669176; ETN69059.1; -; Genomic_DNA.
DR   RefSeq; XP_013291286.1; XM_013435832.1.
DR   GeneID; 25341213; -.
DR   KEGG; nai:NECAME_01169; -.
DR   CTD; 25341213; -.
DR   KO; K11406; -.
DR   Proteomes; UP000053676; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:UniProtKB-EC.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.800.20; -; 1.
DR   InterPro; IPR000286; His_deacetylse.
DR   InterPro; IPR023801; His_deacetylse_dom.
DR   InterPro; IPR037138; His_deacetylse_dom_sf.
DR   InterPro; IPR023696; Ureohydrolase_dom_sf.
DR   PANTHER; PTHR10625; PTHR10625; 1.
DR   Pfam; PF00850; Hist_deacetyl; 1.
DR   PRINTS; PR01270; HDASUPER.
DR   SUPFAM; SSF52768; SSF52768; 1.
PE   4: Predicted;
KW   Chromatin regulator {ECO:0000256|SAAS:SAAS00894233};
KW   Complete proteome {ECO:0000313|Proteomes:UP000053676};
KW   Hydrolase {ECO:0000256|SAAS:SAAS00870288};
KW   Nucleus {ECO:0000256|SAAS:SAAS00894277};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW   Transcription {ECO:0000256|SAAS:SAAS00894309};
KW   Transcription regulation {ECO:0000256|SAAS:SAAS00894290}.
FT   DOMAIN      413    718       Hist_deacetyl. {ECO:0000259|Pfam:
FT                                PF00850}.
SQ   SEQUENCE   788 AA;  85160 MW;  725858944EFC0E32 CRC64;
     MCQVFKQKQM DLMAHFERAQ QALNMQHLQQ YYQTLQQHAQ QQVANNAAQA GPERMDEGLC
     DAAVAPLALA SSMGSLLGSS QSPTTSREAP PQRVRSEHRN ASTNSSSQTI SQHTKDRLKN
     MIAQRNREGS QTNLAGTPPQ QHAPMSPQVN VSSPHFEPYR VPVSLHTAQA VSSQPSSEYQ
     LRKVNSEPNL KMRIRAKLLS KGSSPVQNQN NFNFTHPQLK RSDSETSGNG ATAGSLPMDA
     LLSNAATAFP PHLIMPSPSL PNLAAPNLAQ APQLPIDLAS LMAAAQLTPF LSLPSLFKTH
     IGLGGGLLEE DVADRAKLAP GLAALGTLSQ QLPVFGNPSL LKQQLRELVL RRKSLVREEP
     EDDDSLCAQP VLSPGQLPTS LGLSDMSGGK ATGLAYDSSM ARHECVCGES SSHVEHGGRV
     QSIWSRLCER IAAKKASLEQ LRMVHSPTYV TFFAVSPTAC LKMEASQLPL KSFVQLPCGG
     IGIDSDTYFN DATTQTAARV AAGSLIELAS QVAENRLRNG FACIRPPGHH SERDQAMGFC
     FFNNVAITAR YLQNRYPQQC SRIAIIDWDV HHGNGTQLCF EEDPSVLYLS LHRHDNGNFF
     PGTGAVTEVG RGAGKGFSVN VPFSGGVMRD ADYLAAWRVI VQPVLEQFQP TFILVSAGFD
     ACCGHPNALG GYKISAEMFG FMTRQLMGFA GGRVVLALEG GYDLASISDA AEQCVKVLCG
     DDDKAGVLKN EALEGIPCLS AQETIQKVIA IHKGYWPTLT AEQGLSISEL HWQTVGRQFQ
     KLTMGTVS
//
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