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Database: UniProt/TrEMBL
Entry: W5P655_SHEEP
LinkDB: W5P655_SHEEP
Original site: W5P655_SHEEP 
ID   W5P655_SHEEP            Unreviewed;       921 AA.
AC   W5P655;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   25-OCT-2017, entry version 31.
DE   SubName: Full=Hexokinase 1 {ECO:0000313|Ensembl:ENSOARP00000005909};
GN   Name=HK1 {ECO:0000313|Ensembl:ENSOARP00000005909};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000005909, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000005909, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000005909};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
RA   Wang J., Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000005909}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the hexokinase family.
CC       {ECO:0000256|SAAS:SAAS00672880}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOARP00000005909}.
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DR   EMBL; AMGL01071348; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01071349; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01071350; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01071351; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01071352; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01071353; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_011960600.1; XM_012105210.2.
DR   UniGene; Oar.6581; -.
DR   Ensembl; ENSOART00000005999; ENSOARP00000005909; ENSOARG00000005491.
DR   GeneID; 100036759; -.
DR   CTD; 3098; -.
DR   GeneTree; ENSGT00390000017159; -.
DR   OMA; YDDQQCE; -.
DR   OrthoDB; EOG091G08MD; -.
DR   Proteomes; UP000002356; Chromosome 25.
DR   ExpressionAtlas; W5P655; baseline.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0045121; C:membrane raft; IEA:Ensembl.
DR   GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR   GO; GO:0097228; C:sperm principal piece; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004340; F:glucokinase activity; IEA:Ensembl.
DR   GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR   GO; GO:0001678; P:cellular glucose homeostasis; IEA:InterPro.
DR   GO; GO:0072655; P:establishment of protein localization to mitochondrion; IEA:Ensembl.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-KW.
DR   GO; GO:0072656; P:maintenance of protein location in mitochondrion; IEA:Ensembl.
DR   InterPro; IPR001312; Hexokinase.
DR   InterPro; IPR019807; Hexokinase_BS.
DR   InterPro; IPR022673; Hexokinase_C.
DR   InterPro; IPR022672; Hexokinase_N.
DR   PANTHER; PTHR19443; PTHR19443; 4.
DR   Pfam; PF00349; Hexokinase_1; 2.
DR   Pfam; PF03727; Hexokinase_2; 2.
DR   PROSITE; PS00378; HEXOKINASE_1; 2.
DR   PROSITE; PS51748; HEXOKINASE_2; 2.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00672869};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002356};
KW   Glycolysis {ECO:0000256|SAAS:SAAS00672870};
KW   Kinase {ECO:0000256|SAAS:SAAS00672871};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00672883};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Transferase {ECO:0000256|SAAS:SAAS00672884}.
FT   DOMAIN       26    223       Hexokinase_1. {ECO:0000259|Pfam:PF00349}.
FT   DOMAIN      229    463       Hexokinase_2. {ECO:0000259|Pfam:PF03727}.
FT   DOMAIN      474    671       Hexokinase_1. {ECO:0000259|Pfam:PF00349}.
FT   DOMAIN      677    911       Hexokinase_2. {ECO:0000259|Pfam:PF03727}.
SQ   SEQUENCE   921 AA;  102541 MW;  BFE9D488C884CBAE CRC64;
     MGQTCQRGWC TETENSIRPP LTESKIDKYL YAMRLSDETL LDIMNRFKKE MKNGLSRDFN
     PTATVKMLPT FVRSIPDGSE KGDFIALDLG GSSFRILRVQ VNHEQNQAVH MESEVYDTPE
     NIMHGSGSQL FDHVAECLGD FMEKKKIKDK KLPVGFTFSF PCRQSRIDEA ILITWTKRFK
     ASGVEGTDVV KLLDKAIKKR GDYDANIVAV VNDTVGTMMT CGYDDQLCEV GLIIGTGTNA
     CYMEELRHID LVEGDEGRMC INTEWGAFGD DGALEDIRTE FDREIDRGSL NPGKQLFEKM
     VSGMYLGELV RLILVKMAKE GLLFEGRITP ELLTRGKFNT SDVSAIEKNK EGLHNAKEIL
     TRLGVEPSND DCVSVQHVCT IVSFRSANLV AATLGAILSR LRDNKGTPRL RTTVGVDGSL
     YKTHPQYSRR FHKTLRRLVP DCDVRFLLSE SGSGKGAAMV TAVAYRLAEQ HRQIEETLAH
     FSLTKEMLLE VKKRMRAEME LGLGKQTHDK AVVKMLPSFV RSIPDGTENG DFLALDLGGT
     NFRVLLVKIR SGKKRSVEMH NKIYAIPIEI MQGTGEELFD HIVSCISDFL DYMGIKGPKM
     PLGFTFSFPC KQTSLDAGIL ITWTKGFKAT DCVGHDVATL LREAIKRREE FDLDVVAVVN
     DTVGTMMTCA YEEPSCEVGL IVGTGSNACY MEEMKNVETL EGNQGQMCIN MEWGAFGDNG
     CLDDIRTIYD KLVDEFSLNS GKQRYEKMIS GMYLGEIVRN ILIDFAKRGF LFRGQISEPL
     KTRGLFQTKY LSQIESDRLA LLQVRAILQQ LGLNSTCDDS ILVKTVCGVV SKRAAQLCGA
     GMAAVGDKIR ENRGLDRLNV TVGVDGTLYK LHPHFSRIMH QTVKELSPKC NVSFLLSEDG
     SGKGAALITA VGVRLRQEMS S
//
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