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Database: UniProt/TrEMBL
Entry: W6REZ0_PSEP5
LinkDB: W6REZ0_PSEP5
Original site: W6REZ0_PSEP5 
ID   W6REZ0_PSEP5            Unreviewed;       742 AA.
AC   W6REZ0;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   07-JUN-2017, entry version 18.
DE   SubName: Full=Isocitrate dehydrogenase {ECO:0000313|EMBL:CDM40439.1};
DE            EC=1.1.1.42 {ECO:0000313|EMBL:CDM40439.1};
GN   Name=icd {ECO:0000313|EMBL:CDM40439.1};
GN   ORFNames=BN5_1863 {ECO:0000313|EMBL:CDM40439.1};
OS   Pseudomonas pseudoalcaligenes (strain CECT 5344).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas;
OC   Pseudomonas oleovorans/pseudoalcaligenes group.
OX   NCBI_TaxID=1182590 {ECO:0000313|EMBL:CDM40439.1, ECO:0000313|Proteomes:UP000032841};
RN   [1] {ECO:0000313|EMBL:CDM40439.1, ECO:0000313|Proteomes:UP000032841}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CECT 5344 {ECO:0000313|Proteomes:UP000032841};
RA   Wibberg D., Puehler A., Schlueter A.;
RT   "Complete genome sequence of the cyanide-degrading bacterium
RT   Pseudomonas pseudoalcaligenes CECT 5344.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; HG916826; CDM40439.1; -; Genomic_DNA.
DR   RefSeq; WP_003460437.1; NZ_HG916826.1.
DR   EnsemblBacteria; CDM40439; CDM40439; BN5_1863.
DR   KEGG; ppse:BN5_1863; -.
DR   KO; K00031; -.
DR   Proteomes; UP000032841; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000032841};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Oxidoreductase {ECO:0000313|EMBL:CDM40439.1}.
FT   REGION      133    140       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       350    350       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       548    548       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       552    552       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     146    146       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     547    547       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        255    255       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        420    420       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   742 AA;  81912 MW;  562C2BBF049C0335 CRC64;
     MSTPSKIIYT FTDEAPALAT YSLLPIVEAF AASANISVET RDISLAGRIL ASFADRLDAD
     KRIDDDLAKL AELTLQPDAN IIKLPNISAS VPQLKAAIAE LQAQGYNIPD FPEDPQSDED
     KEVRGRYAKI LGSAVNPVLR EGNSDRRAPA AVKAYARKHP HSMGKWSMAS QSHADYMRGG
     DFFSSEQSIT MAKAGDVRIE FVGKDGKVEV KKQLALQEGE VFDSMFMSCR KLRDFFEKTL
     QDCKETGVMW SLHVKATMMK VSHPIVFGHA VSVYYKDVFD KYGELFKELG VNPNNGISSV
     YDKIKALPAS QQEEILHDIH EVYAHRPEMA MVDSVKGITN LHIPSDVIVD ASMPAMIRNS
     GQMWGKDGKQ KDTKAVMPES TYARIYQEMI NFCKTNGAFD PTTMGSVPNV GLMAQKAEEY
     GSHDKTFEMT ADGTMRVVAA DGTVLMQQQV EAGDIWRACQ TKDAPIRDWV KLAVTRARQS
     NTPAIFWLDP ERAHDRELQK KVELYLKDHD LTGLDIRMMG YNEAIRVSME RMIRGQDTIS
     VTGNVLRDYL TDLFPIMELG TSAKMLSIVP LMAGGGMYET GAGGSAPKHV QQLVEENYLR
     WDSLGEFLAL AVSLEETGIK TNNAKAKVLG KTLDQATGKL LDNNKSPARK VGEIDNRGSH
     FYLALYWAQA LAEQNDDAEL KAHFAPLAKQ LTEQEATIVA ELAAVQGKPV DIGGYYRSNP
     ELTSKVMRPS ATFNAALAAL NA
//
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