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Database: UniProt/TrEMBL
Entry: W7MHW7_GIBM7
LinkDB: W7MHW7_GIBM7
Original site: W7MHW7_GIBM7 
ID   W7MHW7_GIBM7            Unreviewed;       984 AA.
AC   W7MHW7;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   25-OCT-2017, entry version 23.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   ORFNames=FVEG_10341 {ECO:0000313|EMBL:EWG51338.1};
OS   Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and
OS   stalk rot fungus) (Fusarium verticillioides).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Hypocreomycetidae; Hypocreales; Nectriaceae;
OC   Fusarium; Fusarium fujikuroi species complex.
OX   NCBI_TaxID=334819 {ECO:0000313|EMBL:EWG51338.1, ECO:0000313|Proteomes:UP000009096};
RN   [1] {ECO:0000313|EMBL:EWG51338.1, ECO:0000313|Proteomes:UP000009096}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M3125 / FGSC 7600 {ECO:0000313|Proteomes:UP000009096};
RX   PubMed=20237561; DOI=10.1038/nature08850;
RA   Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J.,
RA   Daboussi M.-J., Di Pietro A., Dufresne M., Freitag M., Grabherr M.,
RA   Henrissat B., Houterman P.M., Kang S., Shim W.-B., Woloshuk C.,
RA   Xie X., Xu J.-R., Antoniw J., Baker S.E., Bluhm B.H., Breakspear A.,
RA   Brown D.W., Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M.,
RA   Danchin E.G.J., Diener A., Gale L.R., Gardiner D.M., Goff S.,
RA   Hammond-Kosack K.E., Hilburn K., Hua-Van A., Jonkers W., Kazan K.,
RA   Kodira C.D., Koehrsen M., Kumar L., Lee Y.-H., Li L., Manners J.M.,
RA   Miranda-Saavedra D., Mukherjee M., Park G., Park J., Park S.-Y.,
RA   Proctor R.H., Regev A., Ruiz-Roldan M.C., Sain D., Sakthikumar S.,
RA   Sykes S., Schwartz D.C., Turgeon B.G., Wapinski I., Yoder O.,
RA   Young S., Zeng Q., Zhou S., Galagan J., Cuomo C.A., Kistler H.C.,
RA   Rep M.;
RT   "Comparative genomics reveals mobile pathogenicity chromosomes in
RT   Fusarium.";
RL   Nature 464:367-373(2010).
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000256|RuleBase:RU000617}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|RuleBase:RU004196}.
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DR   EMBL; DS022255; EWG51338.1; -; Genomic_DNA.
DR   RefSeq; XP_018757529.1; XM_018899460.1.
DR   STRING; 117187.FVEG_10341T0; -.
DR   GeneID; 30067935; -.
DR   KEGG; fvr:FVEG_10341; -.
DR   KO; K10777; -.
DR   Proteomes; UP000009096; Chromosome 9.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd00027; BRCT; 2.
DR   Gene3D; 1.10.3260.10; -; 1.
DR   Gene3D; 3.40.50.10190; -; 2.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR029710; LIG4.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR10459:SF7; PTHR10459:SF7; 1.
DR   Pfam; PF16589; BRCT_2; 2.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   SMART; SM00292; BRCT; 2.
DR   SUPFAM; SSF117018; SSF117018; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF52113; SSF52113; 2.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS50172; BRCT; 2.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000617};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009096};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|RuleBase:RU000617, ECO:0000313|EMBL:EWG51338.1};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000617};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009096}.
FT   DOMAIN      427    552       DNA_LIGASE_A3. {ECO:0000259|PROSITE:
FT                                PS50160}.
FT   DOMAIN      720    802       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   DOMAIN      882    983       BRCT. {ECO:0000259|PROSITE:PS50172}.
SQ   SEQUENCE   984 AA;  112793 MW;  4FE10ECD283C23DD CRC64;
     MSQTDEAQRE DEIQYGIVGM TREEIEEKFP NRPKNHSKTL VFSELFREVF NPLNENKKQN
     ATGTGPRKGF RGVNKLSPHE QRRHIIERFI TRWRKEVGPD FYPALRLILP DKDRDRGVYG
     LKENTIGKLL VKLMKIDKNS EDGYNLLHWK LPGQTTASRL AGDFAGRCFE VISKRPMRTE
     VGNMSIAEVN EQLDKLAASI GEAENLRVFE TFYNRMNSEE LMWLIRIVLK QMKVGATEKT
     FLDLWHPDGD ALFSVSSSLR RVCWELHDPE TRLEQEETGV ALMQCFQPQL AQFQMPSSFE
     KMIALLRPTE QDPEFWIEEK LDGERMQVHM VQDKSHPGGK RFCFWSRKAK DYTYLYGDGL
     QDENSSLTRH LKNAFASGVK NLILDGEMIT WDMGVDKIVP FGTLKTAALS EQKNKSDTDS
     AGHRPLFRTF DILYLNNKPL TQYTLRDRHR ALEKAIKPVH RRLEIHSYAK ATSADAIEPL
     LREVVANASE GLVLKNPRSM YRLNSRNDDW LKVKPEYMSE FGESLDCVII GGYYGSGKRG
     GMLSSFLCGL RVTQNHIQAG ANPEKCFSFF KVGGGFRAED YAEIRHRTEG KWIEWDQKNP
     PSKYIELGGG ELRQYERPDV WIRPKDSVVV SVKAASVGPS DQFARGFTLR FPRFRRLRLD
     RTWDTALSLE EFQELKERVD EESKEKAMTV EDRKRRNPKR VKRELIIAGE DAIVPESKGA
     TTDLFKGLDF CVLSEALRPY KKTKTQLETI IKENGGTVVQ RAVPGTNMVL IADKKVVKVA
     SLIKGGAVDI IRPKWIRDCL EQELGAFLLP FEPSHLFHAT DELQGAAEDN TDQFGDSYAR
     DLSIEELREL MHDIPKIEDG THFDKDEFLQ QLEEHGNDLG RLRSFTFRRC VVLFHAVEAG
     DNKISRLKHL VKYGGGNVTN DTNDLSVTHV VIEGDDLMQV GEAADMVRKE LSSRRVQPRL
     VTGKWIDDCW NESTLLDEEQ FMIP
//
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