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Database: UniProt/TrEMBL
Entry: W8QXD1_PSEST
LinkDB: W8QXD1_PSEST
Original site: W8QXD1_PSEST 
ID   W8QXD1_PSEST            Unreviewed;       741 AA.
AC   W8QXD1;
DT   14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT   14-MAY-2014, sequence version 1.
DT   22-NOV-2017, entry version 22.
DE   SubName: Full=Isocitrate dehydrogenase {ECO:0000313|EMBL:AHL75280.1};
DE            EC=1.1.1.42 {ECO:0000313|EMBL:AHL75280.1};
GN   ORFNames=CH92_09180 {ECO:0000313|EMBL:AHL75280.1};
OS   Pseudomonas stutzeri (Pseudomonas perfectomarina).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=316 {ECO:0000313|EMBL:AHL75280.1, ECO:0000313|Proteomes:UP000019522};
RN   [1] {ECO:0000313|EMBL:AHL75280.1, ECO:0000313|Proteomes:UP000019522}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=28a24 {ECO:0000313|EMBL:AHL75280.1,
RC   ECO:0000313|Proteomes:UP000019522};
RA   Baltrus D., Dougherty K.;
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP007441; AHL75280.1; -; Genomic_DNA.
DR   RefSeq; WP_025241452.1; NZ_CP007441.1.
DR   EnsemblBacteria; AHL75280; AHL75280; CH92_09180.
DR   GeneID; 31552727; -.
DR   KEGG; pstt:CH92_09180; -.
DR   PATRIC; fig|316.77.peg.1835; -.
DR   KO; K00031; -.
DR   Proteomes; UP000019522; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   PANTHER; PTHR36999; PTHR36999; 1.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000019522};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Oxidoreductase {ECO:0000313|EMBL:AHL75280.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019522}.
FT   REGION      133    140       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       350    350       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       548    548       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       552    552       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     146    146       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     547    547       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        255    255       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        420    420       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   741 AA;  81348 MW;  B29B58F762A4DF55 CRC64;
     MSTRSKIIYT FTDEAPALAT YSLLPIVEAF AASAGIAVET RDISLAGRIL ASFADQLDAD
     KVVADDLAKL AELTNQPDAN IVKLPNISAS VPQLKAAIAE LQALGYNIPN FPEDPQTEAE
     KDARARYSKV LGSAVNPVLR EGNSDRRAPA AVKAFARKHP HSMGKWSKAS QSHADYMRGG
     DFFSSEQSIT MDRAGDVRIE FVGKDGQVEV KKTVSLQNGE VLDGMFMSCQ KLRAFFEDTL
     QDCKETGVMW SLHVKATMMK ISHPIVFGHA VSVYYKDVFD KYGELFKELG VNPNNGLSSV
     YDKIKSLPDS QQEEILHDIH ACYAGRPEMA MVDSVKGITN LHIPSDVIVD ASMPAMIRSS
     GQMWGKDGKL KDTKAVMPES TYARIYQEMI NFCKTNGAFD PTTMGSVPNV GLMAQKAEEY
     GSHDKTFEMT ADGTMRVVLG DGTVLMQHAV EKGDIWRACQ TKDAPIRDWV KLAVTRARQS
     DTPAIFWLDP ERAHDRELQK KVEAYLQEHD LTGLDIRMMG YNEAIRVSME RLIRGQDTIS
     VTGNVLRDYL TDLFPIMELG TSAKMLSIVP LMAGGGMYET GAGGSAPKHV QQLIEENHLR
     WDSLGEFLAL AVSLEETGIK TDNLKAKLLG KALDAATGKL LDNNKSPSRR TGELDNRGSH
     FYLALYWAQE LAAQTEDSEL QAHFAPLAKQ LSENEQAIIA ELAAVQGEPV EIGGYYRTNS
     DLTSQVMRPS ATFNAALAAL G
//
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