UniProt/TrEMBL: W8UY26

Database: UniProt/TrEMBL
Entry: W8UY26_STAAU

LinkDB:  W8UY26_STAAU 
Original site:  W8UY26_STAAU

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Ontology (5)   
   GO (5)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (1)   
   KEGG GENES (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (23)   
   EMBL (23)   
Protein domain (14)   
   InterPro (8)   
   Pfam (2)   
   PROSITE (3)   
   SMART (1)   
Literature (2)   
   PubMed (2)   
All databases (47)   

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ID   W8UY26_STAAU            Unreviewed;       505 AA.
AC   W8UY26; A0A0D1HVS5; A0A1E8WWA2;
DT   14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT   14-MAY-2014, sequence version 1.
DT   27-MAR-2024, entry version 86.
DE   RecName: Full=Catalase {ECO:0000256|RuleBase:RU000498};
DE            EC=1.11.1.6 {ECO:0000256|RuleBase:RU000498};
GN   Name=katA {ECO:0000313|EMBL:CAA4381257.1};
GN   Synonyms=katA_1 {ECO:0000313|EMBL:CAD7354610.1}, katE
GN   {ECO:0000313|EMBL:GBV19215.1};
GN   ORFNames=C7M54_07725 {ECO:0000313|EMBL:AWW96490.1}, CV021_11030
GN   {ECO:0000313|EMBL:PPJ73260.1}, EP54_12365
GN   {ECO:0000313|EMBL:KMR56115.1}, EQ90_07505
GN   {ECO:0000313|EMBL:KMR36519.1}, FAF17_00925
GN   {ECO:0000313|EMBL:TJY14236.1}, G6Y24_03910
GN   {ECO:0000313|EMBL:NGW66643.1}, GO814_05715
GN   {ECO:0000313|EMBL:MVK34632.1}, GO852_08855
GN   {ECO:0000313|EMBL:MVK03035.1}, GO942_07895
GN   {ECO:0000313|EMBL:MVM10613.1}, GQX37_06090
GN   {ECO:0000313|EMBL:NUY12115.1}, GZ156_12715
GN   {ECO:0000313|EMBL:NDQ61383.1}, M1K003_0179
GN   {ECO:0000313|EMBL:GBV19215.1}, NCTC13131_02158
GN   {ECO:0000313|EMBL:CAD7354610.1}, NCTC6133_01707
GN   {ECO:0000313|EMBL:SUK45009.1}, QU38_13035
GN   {ECO:0000313|EMBL:KIT95850.1}, SA950122_02739
GN   {ECO:0000313|EMBL:QLI00595.1}, SAMEA2078260_01772
GN   {ECO:0000313|EMBL:CAA4381257.1}, SAMEA2078588_02050
GN   {ECO:0000313|EMBL:CAA6105777.1}, SAMEA2080344_02156
GN   {ECO:0000313|EMBL:CAA6373837.1}, SAMEA2081063_02080
GN   {ECO:0000313|EMBL:CAA4695463.1}, SAMEA4008575_02256
GN   {ECO:0000313|EMBL:CAC5805312.1}, SAMEA70146418_02764
GN   {ECO:0000313|EMBL:CAC8237480.1}, SAMEA70153168_00530
GN   {ECO:0000313|EMBL:CAC8217249.1};
OS   Staphylococcus aureus.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1280 {ECO:0000313|EMBL:KMR36519.1};
RN   [1] {ECO:0000313|EMBL:KMR36519.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CA15 {ECO:0000313|EMBL:KMR36519.1}, and M121
RC   {ECO:0000313|EMBL:KMR56115.1};
RX   PubMed=26048971; DOI=10.1093/infdis/jiv320;
RA   Planet P.J., Diaz L., Kolokotronis S.O., Narechania A., Reyes J., Xing G.,
RA   Rincon S., Smith H., Panesso D., Ryan C., Smith D.P., Guzman M., Zurita J.,
RA   Sebra R., Deikus G., Nolan R.L., Tenover F.C., Weinstock G.M.,
RA   Robinson D.A., Arias C.A.;
RT   "Parallel Epidemics of Community-Associated Methicillin-Resistant
RT   Staphylococcus aureus USA300 Infection in North and South America.";
RL   J. Infect. Dis. 212:1874-1882(2015).
RN   [2] {ECO:0000313|EMBL:KIT95850.1, ECO:0000313|Proteomes:UP000032274}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SA-120 {ECO:0000313|EMBL:KIT95850.1,
RC   ECO:0000313|Proteomes:UP000032274};
RA   Crovadore J., Chablais R., Tonacini J., Schnyder B., Lefort F.;
RT   "Characterization of Swiss Staphylococcus aureus strains involved in food
RT   poisoning.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Proteomes:UP000265645}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M1K003 {ECO:0000313|Proteomes:UP000265645};
RA   Nakamura Y., Takahashi H., Takaya A., Inoue Y., Katayama Y., Kusuya Y.,
RA   Shoji T., Takada S., Nakagawa S., Oguma R., Ozawa N., Yamaide F.,
RA   Suzuki S., Villaruz A., Otto M., Matsue H., Nunez G., Shimojo N.;
RT   "Protection against atopic dermatitis through acquisition of Staphylococcus
RT   quorum-sensing agr mutations in the skin.";
RL   Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:PPJ73260.1, ECO:0000313|Proteomes:UP000238775}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=G703N2B1 {ECO:0000313|EMBL:PPJ73260.1,
RC   ECO:0000313|Proteomes:UP000238775};
RA   Founou R.C., Founou L., Allam M., Ismail A., Essack S.Y.;
RL   Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:AWW96490.1, ECO:0000313|Proteomes:UP000249552}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CMRSA-3 {ECO:0000313|EMBL:AWW96490.1,
RC   ECO:0000313|Proteomes:UP000249552};
RA   McClure J.M., Shideler S.M., Zhang K.;
RT   "Complete genome sequence of Canadian epidemic MRSA strain CMRSA3.";
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:SUK45009.1, ECO:0000313|Proteomes:UP000255091}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC6133 {ECO:0000313|EMBL:SUK45009.1,
RC   ECO:0000313|Proteomes:UP000255091};
RG   Pathogen Informatics;
RA   Doyle S.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|EMBL:GBV19215.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=M1K003 {ECO:0000313|EMBL:GBV19215.1};
RA   Nakamura Y., Takahashi H., Takaya A., Inoue Y., Katayama Y., Kusuya Y.,
RA   Shoji T., Takada S., Nakagawa S., Oguma R., Ozawa N., Yamaide F.,
RA   Suzuki S., Villaruz A., Otto M., Matsue H., Nunez G., Shimojo N.;
RT   "Protection against atopic dermatitis through acquisition of Staphylococcus
RT   quorum-sensing agr mutations in the skin.";
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|EMBL:TJY14236.1, ECO:0000313|Proteomes:UP000306447}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=42 {ECO:0000313|EMBL:TJY14236.1,
RC   ECO:0000313|Proteomes:UP000306447};
RA   Fouts D., Sutton G., Singh I., Nguyen K.;
RT   "WGS of SAMN11458133.";
RL   Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN   [9] {ECO:0000313|EMBL:QLI00595.1, ECO:0000313|Proteomes:UP000509140}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=950122 {ECO:0000313|EMBL:QLI00595.1,
RC   ECO:0000313|Proteomes:UP000509140};
RA   Cortes M.F., Botelho A.M.N., Bandeira P.T., Mouton W., Badiou C., Bess M.,
RA   Lima N.C.B., Soares A.E.R., Souza R.C., Almeida L.G.P., Vasconcelos A.T.R.,
RA   Nicolas M.F., Vandenesch F., Laurent F., Planet P., Figueiredo A.M.S.;
RL   Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
RN   [10] {ECO:0000313|Proteomes:UP000430661, ECO:0000313|Proteomes:UP000471199}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S_1081.LBCF.DN {ECO:0000313|EMBL:MVM10613.1,
RC   ECO:0000313|Proteomes:UP000478867}, S_2062.LAUP.DI
RC   {ECO:0000313|EMBL:MVK34632.1, ECO:0000313|Proteomes:UP000471199}, and
RC   S_2078.LLFX.AN {ECO:0000313|EMBL:MVK03035.1,
RC   ECO:0000313|Proteomes:UP000430661};
RA   Stine O.C.;
RT   "Implementation of targeted gown and glove precautions to prevent
RT   Staphylococcus aureus acquisition in community-based nursing homes.";
RL   Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
RN   [11] {ECO:0000313|EMBL:NUY12115.1, ECO:0000313|Proteomes:UP000547874}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UE1097 {ECO:0000313|EMBL:NUY12115.1,
RC   ECO:0000313|Proteomes:UP000547874};
RX   PubMed=32562543;
RA   Castro B.E., Berrio M., Vargas M.L., Carvajal L.P., Millan L.V., Rios R.,
RA   Hernandez A.K., Rincon S., Cubides P., Forero E., Dinh A., Seas C.,
RA   Munita J.M., Arias C.A., Reyes J., Diaz L.;
RT   "Detection of heterogeneous vancomycin intermediate resistance in MRSA
RT   isolates from Latin America.";
RL   J. Antimicrob. Chemother. 0:0-0(2020).
RN   [12] {ECO:0000313|EMBL:NDQ61383.1, ECO:0000313|Proteomes:UP000462022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=67-013 {ECO:0000313|EMBL:NDQ61383.1,
RC   ECO:0000313|Proteomes:UP000462022};
RA   Little S.V., Hillhouse A.E., Cohen N.D., Lawhon S.D., Bryan L.K.;
RT   "Analysis of Virulence and Antimicrobial Resistance Gene Carriage in
RT   Staphylococcus aureus Infections in Equids Using Whole Genome Sequencing.";
RL   Submitted (JAN-2020) to the EMBL/GenBank/DDBJ databases.
RN   [13] {ECO:0000313|EMBL:NGW66643.1, ECO:0000313|Proteomes:UP000473113}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UG255 {ECO:0000313|EMBL:NGW66643.1,
RC   ECO:0000313|Proteomes:UP000473113};
RA   Castro-Cardozo B., Berrio M., Vargas M.L., Carvajal L.P., Millan L.V.,
RA   Rios R., Hernandez A., Rincon S.L., Cubides P., Forero E., Dinh A.,
RA   Seas C., Munita J.M., Arias C.A., Reyes J., Diaz L.;
RT   "Detection of Heterogeneous Vancomycin Intermediate Resistance in
RT   Methicillin Resistant Staphylococcus aureus Isolates from Latin-America.";
RL   Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
RN   [14] {ECO:0000313|Proteomes:UP000505390, ECO:0000313|Proteomes:UP000507112}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MOS105 {ECO:0000313|EMBL:CAC8237480.1,
RC   ECO:0000313|Proteomes:UP000507112}, MOS114
RC   {ECO:0000313|EMBL:CAC8217249.1, ECO:0000313|Proteomes:UP000507402},
RC   NCTC13131 {ECO:0000313|EMBL:CAD7354610.1}, SG160
RC   {ECO:0000313|EMBL:CAC5805312.1, ECO:0000313|Proteomes:UP000505390},
RC   T012_N10_C04 {ECO:0000313|EMBL:CAA6105777.1,
RC   ECO:0000313|Proteomes:UP000459702}, T012_N16_C08
RC   {ECO:0000313|EMBL:CAA4381257.1, ECO:0000313|Proteomes:UP000442696},
RC   T065_N03_C06 {ECO:0000313|EMBL:CAA4695463.1,
RC   ECO:0000313|Proteomes:UP000443506}, and T197_A02_C01
RC   {ECO:0000313|EMBL:CAA6373837.1, ECO:0000313|Proteomes:UP000459586};
RG   Pathogen Informatics;
RL   Submitted (JUN-2020) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H2O2 = 2 H2O + O2; Xref=Rhea:RHEA:20309, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15379, ChEBI:CHEBI:16240; EC=1.11.1.6;
CC         Evidence={ECO:0000256|ARBA:ARBA00000720,
CC         ECO:0000256|RuleBase:RU000498};
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413;
CC         Evidence={ECO:0000256|PIRSR:PIRSR038928-2};
CC   -!- SIMILARITY: Belongs to the catalase family.
CC       {ECO:0000256|ARBA:ARBA00005329, ECO:0000256|RuleBase:RU000498}.
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DR   EMBL; CP029685; AWW96490.1; -; Genomic_DNA.
DR   EMBL; CACTQT010000009; CAA4381257.1; -; Genomic_DNA.
DR   EMBL; CACTWD010000013; CAA4695463.1; -; Genomic_DNA.
DR   EMBL; CACUNS010000012; CAA6105777.1; -; Genomic_DNA.
DR   EMBL; CACURZ010000013; CAA6373837.1; -; Genomic_DNA.
DR   EMBL; CAIGXB010000009; CAC5805312.1; -; Genomic_DNA.
DR   EMBL; CAIIGN010000001; CAC8217249.1; -; Genomic_DNA.
DR   EMBL; CAIIGD010000016; CAC8237480.1; -; Genomic_DNA.
DR   EMBL; UAUZ02000003; CAD7354610.1; -; Genomic_DNA.
DR   EMBL; BDVT01000001; GBV19215.1; -; Genomic_DNA.
DR   EMBL; JXIG01000629; KIT95850.1; -; Genomic_DNA.
DR   EMBL; LALJ01000013; KMR36519.1; -; Genomic_DNA.
DR   EMBL; LALQ01000062; KMR56115.1; -; Genomic_DNA.
DR   EMBL; WPUV01000030; MVK03035.1; -; Genomic_DNA.
DR   EMBL; WPTS01000025; MVK34632.1; -; Genomic_DNA.
DR   EMBL; WPXC01000013; MVM10613.1; -; Genomic_DNA.
DR   EMBL; JAAFKS010000034; NDQ61383.1; -; Genomic_DNA.
DR   EMBL; JAALTR010000122; NGW66643.1; -; Genomic_DNA.
DR   EMBL; JAANEC010000064; NUY12115.1; -; Genomic_DNA.
DR   EMBL; PGWZ01000407; PPJ73260.1; -; Genomic_DNA.
DR   EMBL; CP045441; QLI00595.1; -; Genomic_DNA.
DR   EMBL; UHAP01000001; SUK45009.1; -; Genomic_DNA.
DR   EMBL; SULE01000026; TJY14236.1; -; Genomic_DNA.
DR   RefSeq; WP_000082539.1; NZ_WYDB01000002.1.
DR   KEGG; saud:CH52_12395; -.
DR   Proteomes; UP000032274; Unassembled WGS sequence.
DR   Proteomes; UP000238775; Unassembled WGS sequence.
DR   Proteomes; UP000249552; Chromosome.
DR   Proteomes; UP000251686; Unassembled WGS sequence.
DR   Proteomes; UP000255091; Unassembled WGS sequence.
DR   Proteomes; UP000265645; Unassembled WGS sequence.
DR   Proteomes; UP000306447; Unassembled WGS sequence.
DR   Proteomes; UP000430661; Unassembled WGS sequence.
DR   Proteomes; UP000442696; Unassembled WGS sequence.
DR   Proteomes; UP000443506; Unassembled WGS sequence.
DR   Proteomes; UP000459586; Unassembled WGS sequence.
DR   Proteomes; UP000459702; Unassembled WGS sequence.
DR   Proteomes; UP000462022; Unassembled WGS sequence.
DR   Proteomes; UP000471199; Unassembled WGS sequence.
DR   Proteomes; UP000473113; Unassembled WGS sequence.
DR   Proteomes; UP000478867; Unassembled WGS sequence.
DR   Proteomes; UP000505390; Unassembled WGS sequence.
DR   Proteomes; UP000507112; Unassembled WGS sequence.
DR   Proteomes; UP000507402; Unassembled WGS sequence.
DR   Proteomes; UP000509140; Chromosome.
DR   Proteomes; UP000547874; Unassembled WGS sequence.
DR   GO; GO:0004096; F:catalase activity; IEA:UniProtKB-EC.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0042744; P:hydrogen peroxide catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   CDD; cd08156; catalase_clade_3; 1.
DR   Gene3D; 2.40.180.10; Catalase core domain; 1.
DR   InterPro; IPR018028; Catalase.
DR   InterPro; IPR040333; Catalase_3.
DR   InterPro; IPR024708; Catalase_AS.
DR   InterPro; IPR024711; Catalase_clade1/3.
DR   InterPro; IPR011614; Catalase_core.
DR   InterPro; IPR002226; Catalase_haem_BS.
DR   InterPro; IPR010582; Catalase_immune_responsive.
DR   InterPro; IPR020835; Catalase_sf.
DR   PANTHER; PTHR11465; CATALASE; 1.
DR   PANTHER; PTHR11465:SF61; CATALASE; 1.
DR   Pfam; PF00199; Catalase; 1.
DR   Pfam; PF06628; Catalase-rel; 1.
DR   PIRSF; PIRSF038928; Catalase_clade1-3; 1.
DR   PRINTS; PR00067; CATALASE.
DR   SMART; SM01060; Catalase; 1.
DR   SUPFAM; SSF56634; Heme-dependent catalase-like; 1.
DR   PROSITE; PS00437; CATALASE_1; 1.
DR   PROSITE; PS00438; CATALASE_2; 1.
DR   PROSITE; PS51402; CATALASE_3; 1.
PE   3: Inferred from homology;
KW   Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|PIRSR:PIRSR038928-2};
KW   Hydrogen peroxide {ECO:0000256|ARBA:ARBA00023324,
KW   ECO:0000256|RuleBase:RU000498};
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR038928-2};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|PIRSR:PIRSR038928-2};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU000498};
KW   Peroxidase {ECO:0000256|ARBA:ARBA00022559, ECO:0000256|RuleBase:RU000498}.
FT   DOMAIN          9..398
FT                   /note="Catalase core"
FT                   /evidence="ECO:0000259|SMART:SM01060"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        56
FT                   /evidence="ECO:0000256|PIRSR:PIRSR038928-1"
FT   ACT_SITE        129
FT                   /evidence="ECO:0000256|PIRSR:PIRSR038928-1"
FT   BINDING         339
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR038928-2"
SQ   SEQUENCE   505 AA;  58380 MW;  F6A17136A32DCBCC CRC64;
     MSQQDKKLTG VFGHPVSDRE NSMTAGPRGP LLMQDIYFLE QMSQFDREVI PERRMHAKGS
     GAFGTFTVTK DITKYTNAKI FSEIGKQTEM FARFSTVAGE RGAADAERDI RGFALKFYTE
     EGNWDLVGNN TPVFFFRDPK LFVSLNRAVK RDPRTNMRDA QNNWDFWTGL PEALHQVTIL
     MSDRGIPKDL RHMHGFGSHT YSMYNDSGER VWVKFHFRTQ QGIENLTDEE AAEIIATDRD
     SSQRDLFEAI EKGDYPKWTM YIQVMTEEQA KNHKDNPFDL TKVWYHDEYP LIEVGEFELN
     RNPDNYFMDV EQAAFAPTNI IPGLDFSPDK MLQGRLFSYG DAQRYRLGVN HWQIPVNQPK
     GVGIENICPF SRDGQMRVVD NNQGGGTHYY PNNHGKFDSQ PEYKKPPFPT DGYGYEYNQR
     QDDDNYFEQP GKLFRLQSED AKERIFTNTA NAMEGVTDDV KRRHIRHCYK ADPEYGKGVA
     KALGIDINSI DLETENDETY ENFEK
//

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