KEGG   Tupaia chinensis (Chinese tree shrew): 102483329Help
Entry
102483329         CDS       T02978                                 

Gene name
PIK3CA
Definition
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Organism
tup  Tupaia chinensis (Chinese tree shrew)
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Signaling pathways regulating pluripotency of stem cells
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Central carbon metabolism in cancer
Choline metabolism in cancer
Module
PI3K-Akt signaling
Brite
KEGG Orthology (KO) [BR:tup00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    102483329 (PIK3CA)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    102483329 (PIK3CA)
   04015 Rap1 signaling pathway
    102483329 (PIK3CA)
   04012 ErbB signaling pathway
    102483329 (PIK3CA)
   04370 VEGF signaling pathway
    102483329 (PIK3CA)
   04630 Jak-STAT signaling pathway
    102483329 (PIK3CA)
   04668 TNF signaling pathway
    102483329 (PIK3CA)
   04066 HIF-1 signaling pathway
    102483329 (PIK3CA)
   04068 FoxO signaling pathway
    102483329 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    102483329 (PIK3CA)
   04024 cAMP signaling pathway
    102483329 (PIK3CA)
   04022 cGMP - PKG signaling pathway
    102483329 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    102483329 (PIK3CA)
   04152 AMPK signaling pathway
    102483329 (PIK3CA)
   04150 mTOR signaling pathway
    102483329 (PIK3CA)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    102483329 (PIK3CA)
  Cell growth and death
   04210 Apoptosis
    102483329 (PIK3CA)
  Cellular commiunity
   04510 Focal adhesion
    102483329 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    102483329 (PIK3CA)
 Organismal Systems
  Immune system
   04611 Platelet activation
    102483329 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    102483329 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    102483329 (PIK3CA)
   04660 T cell receptor signaling pathway
    102483329 (PIK3CA)
   04662 B cell receptor signaling pathway
    102483329 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    102483329 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    102483329 (PIK3CA)
   04670 Leukocyte transendothelial migration
    102483329 (PIK3CA)
   04062 Chemokine signaling pathway
    102483329 (PIK3CA)
  Endocrine system
   04910 Insulin signaling pathway
    102483329 (PIK3CA)
   04915 Estrogen signaling pathway
    102483329 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    102483329 (PIK3CA)
   04917 Prolactin signaling pathway
    102483329 (PIK3CA)
   04921 Oxytocin signaling pathway
    102483329 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    102483329 (PIK3CA)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    102483329 (PIK3CA)
  Digestive system
   04973 Carbohydrate digestion and absorption
    102483329 (PIK3CA)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    102483329 (PIK3CA)
  Nervous system
   04725 Cholinergic synapse
    102483329 (PIK3CA)
   04722 Neurotrophin signaling pathway
    102483329 (PIK3CA)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    102483329 (PIK3CA)
  Development
   04380 Osteoclast differentiation
    102483329 (PIK3CA)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    102483329 (PIK3CA)
   05230 Central carbon metabolism in cancer
    102483329 (PIK3CA)
   05231 Choline metabolism in cancer
    102483329 (PIK3CA)
   05205 Proteoglycans in cancer
    102483329 (PIK3CA)
   05203 Viral carcinogenesis
    102483329 (PIK3CA)
   05210 Colorectal cancer
    102483329 (PIK3CA)
   05212 Pancreatic cancer
    102483329 (PIK3CA)
   05214 Glioma
    102483329 (PIK3CA)
   05221 Acute myeloid leukemia
    102483329 (PIK3CA)
   05220 Chronic myeloid leukemia
    102483329 (PIK3CA)
   05218 Melanoma
    102483329 (PIK3CA)
   05211 Renal cell carcinoma
    102483329 (PIK3CA)
   05215 Prostate cancer
    102483329 (PIK3CA)
   05213 Endometrial cancer
    102483329 (PIK3CA)
   05222 Small cell lung cancer
    102483329 (PIK3CA)
   05223 Non-small cell lung cancer
    102483329 (PIK3CA)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    102483329 (PIK3CA)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    102483329 (PIK3CA)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    102483329 (PIK3CA)
   05166 HTLV-I infection
    102483329 (PIK3CA)
   05162 Measles
    102483329 (PIK3CA)
   05164 Influenza A
    102483329 (PIK3CA)
   05161 Hepatitis B
    102483329 (PIK3CA)
   05160 Hepatitis C
    102483329 (PIK3CA)
   05169 Epstein-Barr virus infection
    102483329 (PIK3CA)
   05146 Amoebiasis
    102483329 (PIK3CA)
   05145 Toxoplasmosis
    102483329 (PIK3CA)
   05142 Chagas disease (American trypanosomiasis)
    102483329 (PIK3CA)
Enzymes [BR:tup01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     102483329 (PIK3CA)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Position
Un
AA seq 1075 aa AA seqDB search
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLVTIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKISHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETATKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWSEWLNYDMYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
AXXXXXXSSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRA
ICTRDPLSEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPI
RPEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFL
LKKALTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLI
NLTDILKQEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMS
SAKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQSQGLDLRM
LPYGCLSIGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAA
IDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVP
FVLTQDFLIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPEL
QSFDDIAYIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3228 nt NT seq  +upstreamnt  +downstreamnt
atgcccccacggccgtcgtcgggtgagctgtggggcatccacttgatgcccccaagaatc
ctcgtggaatgtttactaccaaacgggatgatagtgactttagagtgcctccgtgaggcc
acgctggtgaccataaagcatgagctgtttaaagaagcaagaaagtaccccctccaccag
cttctgcaagatgagtcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgagacaagacgactttgcgaccttcggctttttcaaccgtttttaaaa
gtaatcgaacctgtaggcaaccgtgaagagaagatcctcaaccgagaaattggttttgct
atcggcatgccagtgtgtgaattcgatatggttaaagacccagaagtgcaggacttccgg
agaaacatcctgaacgtctgtaaagaagccgtggaccttagggacctcaattcacctcac
agtagggccatgtatgtctaccctccaaatgtggagtcttcgccagaactgccgaagcac
atttataataaactagacaaagggcaaataatagtggtgatctgggtaatagtttctcca
aataatgacaaacagaagtatactctgaagatcagccacgactgcgtgccagagcaggtc
attgctgaagcgatccggaagaaaactcgaagtatgctgctgtcctctgaacagctaaaa
ctctgcgtcttagaataccagggcaagtatattttaaaagtgtgtggatgtgatgaatac
ttcctagaaaaataccctctgagtcagtataagtatataagaagctgtataatgcttggg
aggatgcccaatttgatgctgatggctaaagagagtctttactcccaactgcccatggac
tgctttaccatgccgtcctactccaggcgcatctccacagccacgccgtacatgaacgga
gagaccgccacgaaatccctctgggttatcaacagcgcactcagaataaaaattctctgc
gctacatacgtgaatgtaaacattagagacatcgataagatctatgttcgaacaggtatc
taccatggaggagaacccttatgtgacaatgtgaatacccagagagtaccttgttccaat
cccaggtggagtgagtggctgaattatgacatgtacattcctgaccttcctcgcgctgct
cgactgtgtctctccatttgctctgttaaaggccgaaaaggtgctaaagaggagcactgc
ccattggcctggggaaatataaacctgttcgattacaccgacactctcgtatctggaaag
atggctttgaatctttggccagtccctcatgggttagaagacttgctgaaccctattggt
gttactgggtcaaacccaaataaagaaactccctgcttagagctggagtttgactggttc
gcannnnnnnnnnnnnnnnnnagcagtgttgtgaagtttccggatatgtctgtgatcgaa
gagcatgccaactggtctgtgtcccgcgaggcaggatttagttactcccacgcaggactg
agtaacagacttgctagagacaatgagttaagagaaaatgacaaagaacagctccgagcc
atctgtacccgagaccccctctctgaaattacggagcaagagaaagatttcctgtggagc
cacagacactattgtgtaactatccctgaaattctacccaaattgcttctgtctgttaaa
tggaactctagagatgaagtagcccagatgtactgcctggtcaaggactggcctcccatc
aggccggagcaggcgatggagcttctggactgtaactacccagaccccatggttcgaggc
tttgctgttcgatgcttggaaaaatatttaacagatgacaaactgtctcagtacctgatt
cagctggtgcaggttctaaaatatgaacaatatttggataacttgcttgtgagattttta
ctcaaaaaagcattgactaatcaaaggattgggcactttttcttttggcatttaaaatcc
gagatgcacaacaaaacggtgagccagaggttcggcctgctcttggagtcctattgccga
gcgtgtgggatgtacctgaagcacctgaacaggcaggtcgaggccatggagaagctcatc
aacctgacggacattctgaaacaggagaagaaggacgagacgcagaaggtacagatgaag
tttttggtagaacagatgaggcggccagacttcatggatgccctccagggctttctgtct
cctctcaaccccgctcatcagctgggaaacctcaggcttgaagagtgtcgaatcatgtcc
tcggcaaaaaggcctctgtggctgaactgggagaacccagacatcatgtccgagttactg
tttcagaacaacgagatcatctttaaaaatggggatgatttacggcaagatatgctgaca
cttcagattatccgcatcatggaaaacatctggcaaagtcaaggtcttgatcttcgaatg
ttaccctacggctgtctgtctatcggtgactgtgtggggctcatcgaggtggtgagaaac
tctcacaccatcatgcagatccagtgcaaaggcggcctgaagggggcgctgcagttcaac
agccacacgctgcaccagtggctcaaagacaagaacaaaggggagatatacgatgccgcc
attgacctgttcacacgctcgtgcgcggggtactgcgtcgccaccttcatcctggggatt
ggggaccgccacaacagcaacatcatggtgaaggacgacgggcagttgtttcatatagat
tttggacactttttggatcacaagaagaaaaagtttggttataaacgagaacgtgtgcca
tttgtattgacacaagatttcttaatagtgatcagcaaaggagcccaagaatgcacaaaa
acaagagaatttgagaggttccaggagatgtgttacaaggcttaccttgccatccggcag
cacgccaacctcttcatcaaccttttctccatgatgctcggctctgggatgccggaactg
cagtcttttgatgacattgcatacattcgaaagaccctggccttggataaaactgagcag
gaggctctggagtacttcatgaagcagatgaatgatgcacaccacggcggctggacgaca
aagatggactggatcttccacaccattaagcagcacgcgttgaactga

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