KEGG   Tupaia chinensis (Chinese tree shrew): 102484500
Entry
102484500         CDS       T02978                                 
Symbol
PIK3R1
Name
(RefSeq) phosphoinositide-3-kinase regulatory subunit 1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
tup  Tupaia chinensis (Chinese tree shrew)
Pathway
tup01521  EGFR tyrosine kinase inhibitor resistance
tup01522  Endocrine resistance
tup01524  Platinum drug resistance
tup04012  ErbB signaling pathway
tup04014  Ras signaling pathway
tup04015  Rap1 signaling pathway
tup04024  cAMP signaling pathway
tup04062  Chemokine signaling pathway
tup04066  HIF-1 signaling pathway
tup04068  FoxO signaling pathway
tup04070  Phosphatidylinositol signaling system
tup04071  Sphingolipid signaling pathway
tup04072  Phospholipase D signaling pathway
tup04140  Autophagy - animal
tup04150  mTOR signaling pathway
tup04151  PI3K-Akt signaling pathway
tup04152  AMPK signaling pathway
tup04210  Apoptosis
tup04211  Longevity regulating pathway
tup04213  Longevity regulating pathway - multiple species
tup04218  Cellular senescence
tup04360  Axon guidance
tup04370  VEGF signaling pathway
tup04380  Osteoclast differentiation
tup04510  Focal adhesion
tup04550  Signaling pathways regulating pluripotency of stem cells
tup04611  Platelet activation
tup04613  Neutrophil extracellular trap formation
tup04620  Toll-like receptor signaling pathway
tup04625  C-type lectin receptor signaling pathway
tup04630  JAK-STAT signaling pathway
tup04650  Natural killer cell mediated cytotoxicity
tup04660  T cell receptor signaling pathway
tup04662  B cell receptor signaling pathway
tup04664  Fc epsilon RI signaling pathway
tup04666  Fc gamma R-mediated phagocytosis
tup04668  TNF signaling pathway
tup04670  Leukocyte transendothelial migration
tup04722  Neurotrophin signaling pathway
tup04725  Cholinergic synapse
tup04750  Inflammatory mediator regulation of TRP channels
tup04810  Regulation of actin cytoskeleton
tup04910  Insulin signaling pathway
tup04914  Progesterone-mediated oocyte maturation
tup04915  Estrogen signaling pathway
tup04917  Prolactin signaling pathway
tup04919  Thyroid hormone signaling pathway
tup04923  Regulation of lipolysis in adipocytes
tup04926  Relaxin signaling pathway
tup04929  GnRH secretion
tup04930  Type II diabetes mellitus
tup04931  Insulin resistance
tup04932  Non-alcoholic fatty liver disease
tup04933  AGE-RAGE signaling pathway in diabetic complications
tup04935  Growth hormone synthesis, secretion and action
tup04960  Aldosterone-regulated sodium reabsorption
tup04973  Carbohydrate digestion and absorption
tup05010  Alzheimer disease
tup05017  Spinocerebellar ataxia
tup05020  Prion disease
tup05100  Bacterial invasion of epithelial cells
tup05135  Yersinia infection
tup05142  Chagas disease
tup05146  Amoebiasis
tup05160  Hepatitis C
tup05161  Hepatitis B
tup05162  Measles
tup05163  Human cytomegalovirus infection
tup05164  Influenza A
tup05165  Human papillomavirus infection
tup05166  Human T-cell leukemia virus 1 infection
tup05167  Kaposi sarcoma-associated herpesvirus infection
tup05168  Herpes simplex virus 1 infection
tup05169  Epstein-Barr virus infection
tup05170  Human immunodeficiency virus 1 infection
tup05171  Coronavirus disease - COVID-19
tup05200  Pathways in cancer
tup05203  Viral carcinogenesis
tup05205  Proteoglycans in cancer
tup05206  MicroRNAs in cancer
tup05207  Chemical carcinogenesis - receptor activation
tup05208  Chemical carcinogenesis - reactive oxygen species
tup05210  Colorectal cancer
tup05211  Renal cell carcinoma
tup05212  Pancreatic cancer
tup05213  Endometrial cancer
tup05214  Glioma
tup05215  Prostate cancer
tup05218  Melanoma
tup05220  Chronic myeloid leukemia
tup05221  Acute myeloid leukemia
tup05222  Small cell lung cancer
tup05223  Non-small cell lung cancer
tup05224  Breast cancer
tup05225  Hepatocellular carcinoma
tup05226  Gastric cancer
tup05230  Central carbon metabolism in cancer
tup05231  Choline metabolism in cancer
tup05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
tup05415  Diabetic cardiomyopathy
tup05417  Lipid and atherosclerosis
tup05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:tup00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    102484500 (PIK3R1)
   04014 Ras signaling pathway
    102484500 (PIK3R1)
   04015 Rap1 signaling pathway
    102484500 (PIK3R1)
   04370 VEGF signaling pathway
    102484500 (PIK3R1)
   04630 JAK-STAT signaling pathway
    102484500 (PIK3R1)
   04668 TNF signaling pathway
    102484500 (PIK3R1)
   04066 HIF-1 signaling pathway
    102484500 (PIK3R1)
   04068 FoxO signaling pathway
    102484500 (PIK3R1)
   04070 Phosphatidylinositol signaling system
    102484500 (PIK3R1)
   04072 Phospholipase D signaling pathway
    102484500 (PIK3R1)
   04071 Sphingolipid signaling pathway
    102484500 (PIK3R1)
   04024 cAMP signaling pathway
    102484500 (PIK3R1)
   04151 PI3K-Akt signaling pathway
    102484500 (PIK3R1)
   04152 AMPK signaling pathway
    102484500 (PIK3R1)
   04150 mTOR signaling pathway
    102484500 (PIK3R1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    102484500 (PIK3R1)
  09143 Cell growth and death
   04210 Apoptosis
    102484500 (PIK3R1)
   04218 Cellular senescence
    102484500 (PIK3R1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    102484500 (PIK3R1)
   04550 Signaling pathways regulating pluripotency of stem cells
    102484500 (PIK3R1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    102484500 (PIK3R1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    102484500 (PIK3R1)
   04613 Neutrophil extracellular trap formation
    102484500 (PIK3R1)
   04620 Toll-like receptor signaling pathway
    102484500 (PIK3R1)
   04625 C-type lectin receptor signaling pathway
    102484500 (PIK3R1)
   04650 Natural killer cell mediated cytotoxicity
    102484500 (PIK3R1)
   04660 T cell receptor signaling pathway
    102484500 (PIK3R1)
   04662 B cell receptor signaling pathway
    102484500 (PIK3R1)
   04664 Fc epsilon RI signaling pathway
    102484500 (PIK3R1)
   04666 Fc gamma R-mediated phagocytosis
    102484500 (PIK3R1)
   04670 Leukocyte transendothelial migration
    102484500 (PIK3R1)
   04062 Chemokine signaling pathway
    102484500 (PIK3R1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    102484500 (PIK3R1)
   04923 Regulation of lipolysis in adipocytes
    102484500 (PIK3R1)
   04929 GnRH secretion
    102484500 (PIK3R1)
   04915 Estrogen signaling pathway
    102484500 (PIK3R1)
   04914 Progesterone-mediated oocyte maturation
    102484500 (PIK3R1)
   04917 Prolactin signaling pathway
    102484500 (PIK3R1)
   04926 Relaxin signaling pathway
    102484500 (PIK3R1)
   04935 Growth hormone synthesis, secretion and action
    102484500 (PIK3R1)
   04919 Thyroid hormone signaling pathway
    102484500 (PIK3R1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    102484500 (PIK3R1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    102484500 (PIK3R1)
  09156 Nervous system
   04725 Cholinergic synapse
    102484500 (PIK3R1)
   04722 Neurotrophin signaling pathway
    102484500 (PIK3R1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    102484500 (PIK3R1)
  09158 Development and regeneration
   04360 Axon guidance
    102484500 (PIK3R1)
   04380 Osteoclast differentiation
    102484500 (PIK3R1)
  09149 Aging
   04211 Longevity regulating pathway
    102484500 (PIK3R1)
   04213 Longevity regulating pathway - multiple species
    102484500 (PIK3R1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102484500 (PIK3R1)
   05206 MicroRNAs in cancer
    102484500 (PIK3R1)
   05205 Proteoglycans in cancer
    102484500 (PIK3R1)
   05207 Chemical carcinogenesis - receptor activation
    102484500 (PIK3R1)
   05208 Chemical carcinogenesis - reactive oxygen species
    102484500 (PIK3R1)
   05203 Viral carcinogenesis
    102484500 (PIK3R1)
   05230 Central carbon metabolism in cancer
    102484500 (PIK3R1)
   05231 Choline metabolism in cancer
    102484500 (PIK3R1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102484500 (PIK3R1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    102484500 (PIK3R1)
   05212 Pancreatic cancer
    102484500 (PIK3R1)
   05225 Hepatocellular carcinoma
    102484500 (PIK3R1)
   05226 Gastric cancer
    102484500 (PIK3R1)
   05214 Glioma
    102484500 (PIK3R1)
   05221 Acute myeloid leukemia
    102484500 (PIK3R1)
   05220 Chronic myeloid leukemia
    102484500 (PIK3R1)
   05218 Melanoma
    102484500 (PIK3R1)
   05211 Renal cell carcinoma
    102484500 (PIK3R1)
   05215 Prostate cancer
    102484500 (PIK3R1)
   05213 Endometrial cancer
    102484500 (PIK3R1)
   05224 Breast cancer
    102484500 (PIK3R1)
   05222 Small cell lung cancer
    102484500 (PIK3R1)
   05223 Non-small cell lung cancer
    102484500 (PIK3R1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    102484500 (PIK3R1)
   05170 Human immunodeficiency virus 1 infection
    102484500 (PIK3R1)
   05161 Hepatitis B
    102484500 (PIK3R1)
   05160 Hepatitis C
    102484500 (PIK3R1)
   05171 Coronavirus disease - COVID-19
    102484500 (PIK3R1)
   05164 Influenza A
    102484500 (PIK3R1)
   05162 Measles
    102484500 (PIK3R1)
   05168 Herpes simplex virus 1 infection
    102484500 (PIK3R1)
   05163 Human cytomegalovirus infection
    102484500 (PIK3R1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102484500 (PIK3R1)
   05169 Epstein-Barr virus infection
    102484500 (PIK3R1)
   05165 Human papillomavirus infection
    102484500 (PIK3R1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    102484500 (PIK3R1)
   05100 Bacterial invasion of epithelial cells
    102484500 (PIK3R1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    102484500 (PIK3R1)
   05142 Chagas disease
    102484500 (PIK3R1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102484500 (PIK3R1)
   05017 Spinocerebellar ataxia
    102484500 (PIK3R1)
   05020 Prion disease
    102484500 (PIK3R1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    102484500 (PIK3R1)
   05418 Fluid shear stress and atherosclerosis
    102484500 (PIK3R1)
   05415 Diabetic cardiomyopathy
    102484500 (PIK3R1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    102484500 (PIK3R1)
   04932 Non-alcoholic fatty liver disease
    102484500 (PIK3R1)
   04931 Insulin resistance
    102484500 (PIK3R1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    102484500 (PIK3R1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102484500 (PIK3R1)
   01524 Platinum drug resistance
    102484500 (PIK3R1)
   01522 Endocrine resistance
    102484500 (PIK3R1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:tup04131]
    102484500 (PIK3R1)
Membrane trafficking [BR:tup04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    102484500 (PIK3R1)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH3_1 SH3_2 SH3_9 Laminin_I FWWh Exonuc_VII_L Bap31_Bap29_C
Other DBs
NCBI-GeneID: 102484500
NCBI-ProteinID: XP_006169589
Position
Un
AA seq 725 aa
MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVAHGFSDGQEARPEEIGWLNGYN
ETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKTETDSEQQALTLPDLAE
QFAPPDIAPPLLIKLVEAIEKKGLECSTLYRTQSSSTPAELRQLLDCDTASVDLEMIDVH
VLADAFKRYLLDLPNPVIPVAVYSEMISLAQEVQSSEEYTQLLKKLIRSPHIPHQYWLTL
QYLLKHFFKLSQTSSKNLLNARVLSEIFSPMLFRFPATSSDSTEHFTKVVEILIATEWSE
RQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDA
STKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKL
DVKLLYPVSKYQQDQVVKEDNIEAVGFKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQM
KRTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEII
DSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLG
NENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYAC
SVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVY
AQQRR
NT seq 2178 nt   +upstreamnt  +downstreamnt
atgagtgccgagggctaccagtaccgagcgctgtacgactataagaaggaacgagaggaa
gatatcgacttgcacttgggtgacattttgactgtgaataaaggatctttagtagcacat
ggattcagtgatggacaagaagccagacctgaagaaatcggctggttaaatggctataat
gaaaccacgggggagaggggagactttccgggaacttatgtagaatatattggaaggaaa
aaaatctcacccccgacaccaaagccccggccacctcgaccccttcctgttgcaccaggt
tcttctaaaactgaaacagacagtgaacaacaagctttgactcttccagatcttgcagag
cagttcgcccctcctgacattgccccacctcttctgatcaagcttgtggaagccattgaa
aagaaaggtctggaatgttcaactctatacagaacacagagctccagcaccccagcagaa
ttacgacagcttcttgattgtgatacggcttctgtggacttggaaatgatcgatgtgcac
gttttagcagatgctttcaaacgctatctcctggacttaccaaatcctgtcattccagta
gccgtttacagtgaaatgatttctttagcccaagaagtacaaagctccgaagaatatacc
cagctattgaagaagctcattagatcgcctcacatacctcatcagtattggcttacactt
cagtatctgctgaaacatttcttcaagctctctcaaacctccagcaaaaatctcttgaat
gcaagagtgctctcagaaattttcagccctatgcttttcagattcccagcaaccagctct
gatagtaccgaacacttcacaaaagttgtagaaattttaattgcaactgaatggagtgag
cgacagcctgcaccagcactgccacctaagccaccaaaacccactactgtagccaacaac
ggtatgaataacaatatgtccttacaagatgctgaatggtactggggtgatatctcaagg
gaagaagtaaatgaaaaacttcgagatacagcagatgggacctttctggtacgagatgca
tctactaaaatgcatggtgattatactcttacactaaggaaaggaggaaataacaaatta
atcaaaatatttcaccgagatgggaaatatggcttctctgacccattaaccttcaattct
gtggttgaattaataaaccactaccggaatgaatctctagctcagtataatcccaaactg
gatgtgaaattactttatccagtatccaaataccaacaggatcaggttgtcaaagaagat
aatattgaagctgtaggttttaaaaagttacatgaatataacactcagtttcaagaaaag
agtagagaatatgatagattgtatgaagaatatactcgtacttcccaggaaattcaaatg
aaaagaacagctattgaagcatttaatgaaaccataaaaatatttgaagaacagtgccaa
acccaggagaggtacagcaaagagtatatagagaagtttaaacgtgaaggcaatgaaaaa
gaaatacaaaggattatgcataattatgataagttaaagtctcgaatcagtgagattatt
gacagtagaagaagattggaggaagacctcaagaagcaggcagctgagtaccgagagatc
gacaaacgcatgaacagcattaaaccagacctcattcagctgagaaagacgagagaccaa
tacttgatgtggttgacccaaaaaggtgttcggcagaagaagttgaacgaatggttgggc
aatgaaaacactgaggaccaatattccctggtggaagacgatgaggatttgccccaccac
gatgagaagacgtggaatgtcggaagcagcaaccgaaataaagctgaaaacctgttgcgg
gggaagcgagatggcacatttctagtccgggagagcagtaaacagggctgctatgcctgc
tctgtagtggtggacggtgaagtaaagcactgtgtcatcaacaagacggcgaccggctat
ggctttgctgagccctataacttgtacagctctctgaaagaactggtgctacattaccaa
cacacctccctcgtgcagcacaatgactccctcaacgtcacactagcctacccggtatat
gcacagcagaggcgatga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (102)   
   KEGG PATHWAY (102)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (3)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (8)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (5)   
   RefSeq(nuc) (1)   
   GenBank (2)   
   EMBL (2)   
Protein domain (10)   
   Pfam (10)   
All databases (140)   

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