KEGG   Ursus maritimus (polar bear): 103661304
Entry
103661304         CDS       T03271                                 
Symbol
NOS1
Name
(RefSeq) nitric oxide synthase, brain
  KO
K13240  nitric-oxide synthase, brain [EC:1.14.13.39]
Organism
umr  Ursus maritimus (polar bear)
Pathway
umr00220  Arginine biosynthesis
umr00330  Arginine and proline metabolism
umr01100  Metabolic pathways
umr04020  Calcium signaling pathway
umr04145  Phagosome
umr04371  Apelin signaling pathway
umr04713  Circadian entrainment
umr04730  Long-term depression
umr04926  Relaxin signaling pathway
umr04970  Salivary secretion
umr05010  Alzheimer disease
umr05014  Amyotrophic lateral sclerosis
umr05022  Pathways of neurodegeneration - multiple diseases
umr05410  Hypertrophic cardiomyopathy
umr05412  Arrhythmogenic right ventricular cardiomyopathy
umr05414  Dilated cardiomyopathy
umr05416  Viral myocarditis
Brite
KEGG Orthology (KO) [BR:umr00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00220 Arginine biosynthesis
    103661304 (NOS1)
   00330 Arginine and proline metabolism
    103661304 (NOS1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    103661304 (NOS1)
   04020 Calcium signaling pathway
    103661304 (NOS1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    103661304 (NOS1)
 09150 Organismal Systems
  09152 Endocrine system
   04926 Relaxin signaling pathway
    103661304 (NOS1)
  09154 Digestive system
   04970 Salivary secretion
    103661304 (NOS1)
  09156 Nervous system
   04730 Long-term depression
    103661304 (NOS1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    103661304 (NOS1)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    103661304 (NOS1)
   05014 Amyotrophic lateral sclerosis
    103661304 (NOS1)
   05022 Pathways of neurodegeneration - multiple diseases
    103661304 (NOS1)
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    103661304 (NOS1)
   05412 Arrhythmogenic right ventricular cardiomyopathy
    103661304 (NOS1)
   05414 Dilated cardiomyopathy
    103661304 (NOS1)
   05416 Viral myocarditis
    103661304 (NOS1)
Enzymes [BR:umr01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.39  nitric-oxide synthase (NADPH)
     103661304 (NOS1)
SSDB
Motif
Pfam: NO_synthase FAD_binding_1 Flavodoxin_1 NAD_binding_1 PDZ PDZ_6 PDZ_2
Other DBs
NCBI-GeneID: 103661304
NCBI-ProteinID: XP_040475349
UniProt: A0A8M1F309
Position
Unknown
AA seq 1463 aa
MENQVFSVQQIQPNVISVRLFKRRVGGLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQA
GDIILAVNGQPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTI
RVTRPLGPATTAVDLSHQSSASKEHTPPVDGAAGPGSGPQHTQDSGREAGSLSNTNSLAP
RRPGQDPTKKSAGVAPQDGQNSELLKEIEPVLSLLTSGSKGIHGAGPSKAETKDAEVQVD
RGVDGKSHKPLPLGVENDRVFSDLWGKGHVPVVLNNPYSEKEQPPASGKQSPTKNGSPSK
CPRFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLPSQQIRRPEDVRTKEQLFP
LAKEFIDQYYSSIKRFGSKAHTERLEEVNKEIEATGTYQLKDTELIYGAKHAWRNASRCV
GRIQWSKLQVFDARDCTTAHGMFNYICNHIKYATNKGNLRSAITIFPQRTDGKHDFRVWN
SQLIRYAGYKQPDGSILGDPANVEFTEICVQQGWKPPRGRFDVLPLLLQANGNDPELFQI
PPELVLEVPIRHPKFEWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVR
DYCDNSRYNILEEVAKKMNLDMRKTSSLWKDQALVEINIAVLYSFQTDKVTIVDHHSATE
SFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPEPWNTHVW
KGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAKRVKATILYATETGKSQAYAKTLCEI
FKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVHE
ERKYPEPLRFFPRKGPPLPQGDPGVRGLAAARDSQQRSYKVRFNSVSSYSDSHKSSGDGP
DLRDNFESAGPLANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCG
QEEAFRTWAKKVFKAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTYMAEAPELTQ
GLSTVHKKRVSAARLLSRQNLQSPKSSRSTIFVRLHTNGNQELQYQPGDHLGVFPGNRED
LVNALIERLEDAPPVNQLVKVELLEERNTALGVISNWTDEHRLPPCTIFQAFKYYLDITT
PPTPLQLQQFASLATSEKEKQRLLVLSRGLQEYEEWKWGKNPTIVEVLEEFPSIQMPSTL
LLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYRTRDGEGPIHHGVCSSWLNRIQADE
VVPCFVRGAPSFHLPRNPQVPCILIGPGTGIAPFRSFWQQRQFDIQHKGMSPCPMVLVFG
CRQSKIDHIYREETLQAKNKGVFRELYTAYSREPDKPKKYVQDVLQEQLAEPVYRALKEQ
GGHIYVCGDVTMAADVLKAIQRIMTQQGKLSAEDAGVFISRLRDDNRYHEDIFGVTLRTY
EVTNRLRSESIAFIEESKKDTDE
NT seq 4392 nt   +upstreamnt  +downstreamnt
atggagaatcaggtgttcagtgttcagcagatccaacccaatgtcatttctgtccgcctc
ttcaagcgcagggtggggggcctgggcttcctggtgaaagagcgggtgagtaagccaccc
gtgatcatctccgacctgatccgagggggcgccgcggagcagagcggcctcatccaggcc
ggcgacatcatcctcgccgtcaacggccagcccttggtggacctgagctatgacagtgcc
ctggaggtgctcaggggcatcgcctctgagacccacgtggtccttattctgaggggcccc
gagggcttcaccactcacctggagaccaccttcaccggggacgggacccccaagaccatc
cgggtgacacggcccctgggccccgccaccacagccgtcgatctgtctcaccagtcatcg
gccagcaaagagcacacaccgccagtggatggggccgcgggtcctggcagtgggccacag
catacccaggacagtgggcgggaagccggctcgctctcaaataccaacagcctggctccc
agacgccctggccaggaccctaccaagaaaagtgccggggtggccccccaggacggccag
aacagtgaattgctcaaagagatagaacctgtgctgagccttctcaccagtgggagcaaa
gggatccatggagcgggaccttccaaggcagagacaaaagatgcggaagtccaggtggac
agaggtgtggacggcaagtcccacaaaccgctgcccctgggcgtggagaatgaccgagtc
ttcagtgacctgtgggggaagggccatgtgcccgtcgtcctcaacaacccgtattcagag
aaggagcagccccctgcctcgggaaaacagtctcccacaaagaatggcagcccctccaag
tgcccccgctttcttaaagtcaagaactgggagaccgacgtggttctcaccgacaccctt
caccttaagagcacactggaaacgggctgcaccgagcacatctgtatgggctccatcatg
ctcccttctcagcaaatacgaaggcctgaagatgtccgcacaaaagaacagctcttccct
cttgccaaagagttcattgatcagtactactcgtcaattaaaagatttggctccaaagcc
cacacagagaggctggaagaagtgaacaaagagatcgaggccacaggcacctaccagctc
aaagacacagagctcatctacggggcgaagcacgcctggcggaatgcctcccgctgcgtt
ggcaggatccagtggtccaagctgcaggtgttcgatgcccgagactgcaccacggctcac
gggatgttcaactacatctgcaaccacatcaagtacgccaccaacaaagggaacctcagg
tctgccatcaccatatttccgcagaggactgacggcaagcacgatttccgagtctggaac
tctcagctcatccgctacgccggctacaagcagcctgacggctccatcctaggggaccca
gccaatgtggaattcacagagatctgcgtacagcagggctggaaacccccaaggggccgc
ttcgatgtcctgccactcctgctccaggccaacggcaacgaccctgagctcttccagatt
cctccagagctggtgttggaagtgcccatcagacaccccaagtttgagtggttcaaggat
ctgggcctgaagtggtacggcctccccgctgtgtctaatatgctgctggagatcggcggc
ctggagttcagcgcctgccccttcagtggctggtacatgggcacagagatcggcgttcgc
gactactgtgacaactctcgatacaacatcctggaggaagtggccaagaagatgaacttg
gatatgaggaagacatcctccctgtggaaggatcaggcgctggtggaaatcaacattgct
gttctctacagcttccagactgacaaagtgaccatcgttgaccaccactctgccaccgag
tccttcattaagcacatggagaatgaataccgctgccgggggggctgccccgccgactgg
gtgtggatcgtgccccccatgtctggcagcatcaccccggtcttccaccaggagatgctc
aactaccggctcaccccctccttcgaataccagcctgagccttggaacacccacgtgtgg
aaaggtaccaatgggacccccacaaagcggcgagccatcggcttcaagaagctggcggaa
gccgtcaagttttcggccaagctcatggggcaggcaatggccaagagggtcaaggcaacc
atcctttatgccacagagacgggcaagtcgcaggcctatgctaaaaccttgtgcgagatc
ttcaaacacgcctttgatgccaaggtgatgtccatggaagaatatgacattgtacacctg
gaacatgaaactctggtcctggtggttaccagcacttttggcaatggagacccccctgag
aatggggagaaattcggctgtgctttgatggaaatgaggcaccccaactccgtgcatgag
gaaaggaagtacccggaacccttgcgtttctttccccgtaaagggcctcccctcccccaa
ggtgacccaggagtccgtggtctggctgcagcccgtgacagccagcagaggagctacaag
gtccgattcaatagcgtttcctcgtattctgactcccataaatcgtcgggcgatgggcca
gacctcagagacaactttgagagtgctggacccctggcaaatgtgaggttctctgtgttt
ggccttggctcccgtgcttacccgcacttctgtgcctttggacatgctgtggacaccctc
ctggaggagctgggaggagagaggatcctaaagatgagggaaggggatgagctgtgtggg
caggaagaggctttcaggacctgggccaagaaggtcttcaaggcagcctgtgatgtgttc
tgtgtgggagatgacgtcaacatcgagaaggccaacaactccctcatcagcaatgaccgc
agctggaagaggaacaaattccgcctcacctacatggccgaagctccagaacttacgcaa
ggtctgtccactgtccacaaaaagcgggtctcagccgctcgactcctcagccgtcagaac
cttcagagccctaaatccagccgatcaaccatcttcgtgcgtctccacaccaacgggaat
caggagctccagtaccagcctggggaccacctgggcgtcttcccaggcaaccgcgaggac
ctcgtgaacgccctgatcgagcggctggaggacgcacccccggtcaaccagctggtgaag
gtggagctgctggaggagcggaacacggctttgggagttatcagtaactggacagatgag
caccgcctcccgccctgcaccatcttccaggccttcaagtattacctggacatcaccacg
ccgccaacgccactgcagctgcagcagtttgcctccctggccaccagcgagaaagagaag
cagcgtctgctggtcctcagcaggggtttgcaggagtacgaggaatggaaatggggcaag
aaccccaccatcgtggaggtgctggaggagttcccgtccatccagatgccctccaccctg
ctcctgacccagctgtccctgctgcagccccgctactattccatcagctcctccccagac
atgtaccctgacgaggtgcacctcaccgtggccatcgtctcctaccgcacccgagatgga
gaaggaccaattcaccacggtgtgtgctcctcctggctcaaccggatacaggctgacgaa
gtggtcccgtgtttcgtgagaggagcacccagcttccacctgccccgaaatccccaagtg
ccctgcatcctcattggcccaggcactggcattgcccctttccgaagcttctggcagcag
cggcaatttgatatccaacacaaagggatgagcccctgccccatggtcctggtgttcggg
tgccggcaatccaagatagaccacatctacagggaggagacgctccaggccaagaacaag
ggggtcttcagagaactgtacacggcctactcccgggagccagacaaaccaaagaagtac
gtgcaggacgtcctgcaggagcagctggcagaaccggtgtaccgagccctgaaggagcaa
gggggccacatctatgtctgcggggacgtcaccatggccgccgatgtcctcaaagccatc
cagcgcatcatgacccagcaggggaaactctcagcagaggatgcgggcgtgttcatcagc
aggctgagggatgacaaccggtaccatgaggatattttcggggtcaccctgcgaacatat
gaagtgaccaaccgccttagatctgaatccattgccttcattgaggagagcaaaaaagac
accgacgagtaa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (17)   
   KEGG PATHWAY (17)   
Chemical substance (9)   
   KEGG COMPOUND (9)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (7)   
   Pfam (7)   
All databases (47)   

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