KEGG   Ursus maritimus (polar bear): 103671121
Entry
103671121         CDS       T03271                                 
Symbol
TH
Name
(RefSeq) tyrosine 3-monooxygenase
  KO
K00501  tyrosine 3-monooxygenase [EC:1.14.16.2]
Organism
umr  Ursus maritimus (polar bear)
Pathway
umr00350  Tyrosine metabolism
umr00790  Folate biosynthesis
umr01100  Metabolic pathways
umr04728  Dopaminergic synapse
umr04917  Prolactin signaling pathway
umr05012  Parkinson disease
umr05030  Cocaine addiction
umr05031  Amphetamine addiction
umr05034  Alcoholism
Module
umr_M00042  Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline
Brite
KEGG Orthology (KO) [BR:umr00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    103671121 (TH)
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    103671121 (TH)
 09150 Organismal Systems
  09152 Endocrine system
   04917 Prolactin signaling pathway
    103671121 (TH)
  09156 Nervous system
   04728 Dopaminergic synapse
    103671121 (TH)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    103671121 (TH)
  09165 Substance dependence
   05030 Cocaine addiction
    103671121 (TH)
   05031 Amphetamine addiction
    103671121 (TH)
   05034 Alcoholism
    103671121 (TH)
Enzymes [BR:umr01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.16  With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.16.2  tyrosine 3-monooxygenase
     103671121 (TH)
SSDB
Motif
Pfam: Biopterin_H TH_ACT TOH_N LTP_2
Other DBs
NCBI-GeneID: 103671121
NCBI-ProteinID: XP_040494728
UniProt: A0A8M1GGD9
Position
Unknown
AA seq 495 aa
MPTPSTASPQAKGFRRAVSELDAKQAEAIMSPRFIGRRQSLIEDARKEREKAEAASAAAS
EPGDPLEAAVVKDKDGKATLNLLFTLRGTKTAPLSRAVKAFETFEAQIHHLETRPAQRPR
AGGPHLEYFVRCEVPSADLPALLSSVRRVAEDVRGAGENKVLWFPRKVSELDKCHHLVTK
FDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYKHGDPIPRVEYTAEEIATWKEVYTTLKGL
YITHACREYLEAFQLLERFSGYREDNIPQLEDVSRFLKERTGFQLRPVAGLLSARDFLAS
LAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEE
IEKLSTLYWFTVEFGLCKQNGEVKAYGAGLLSSYGELLHSLSEEPEIRAFDPDAAAVQPY
QDQTYQSVYFVSESFSDAKDKLRNYASRIQRPFSVKFDPYTLAIDVLDSPHAIRRSLEGV
QEELHTLAHALSAIS
NT seq 1488 nt   +upstreamnt  +downstreamnt
atgcccactcccagcaccgcctccccgcaggccaagggcttccgcagggccgtctccgag
ctggacgccaagcaggccgaggccatcatgtccccgcgcttcattgggcggcgacagagc
ctcatcgaggacgctcgcaaggagcgagagaaggccgaggcagcgtcagccgctgcctcg
gagcccggagaccccctagaggccgccgtggtcaaggacaaggacgggaaggccacgctg
aaccttctcttcaccctacggggcaccaagaccgcgccactgtcccgggccgtgaaggcg
tttgaaacatttgaagcccaaatccaccacctggagacccggcctgcccagcggccacgg
gcaggcggcccccacctggagtactttgtgcgctgtgaggtgcccagcgccgacctgccg
gccctgctcagctccgtgcgccgggtggcggaggacgtgcgtggcgccggggagaacaag
gtcctctggttcccgaggaaagtttccgagctggacaagtgtcaccatctggtcaccaag
tttgaccctgacctggacttggatcacccgggcttctcggaccaggtgtaccgccagcgc
cggaagctgattgcggagatagcgttccagtacaagcacggtgaccctattccccgtgtg
gagtacacggccgaggagatagccacctggaaggaggtctacaccaccctcaagggcctc
tacatcacccacgcctgccgggagtacctggaggccttccagctgctggagcgcttcagc
gggtacagggaggacaacatcccgcagctggaggacgtgtcccgcttcctgaaggagcgg
acaggcttccagctgcggcccgtggctggcctgctgtccgcccgggacttcctggccagc
ctggccttccgagtgttccagtgcacccagtacatccggcacgcctcctcgcccatgcac
tcccctgagccggactgctgccatgagctgctggggcacgtgcccatgctggctgaccgg
acctttgctcagttctcccaggacatcgggctcgcgtccttgggggcttctgacgaggaa
attgagaagctgtccacgctatactggttcacggtggagttcgggctgtgtaagcagaac
ggcgaggtgaaggcctacggtgctgggctgctgtcctcctacggggagctcctgcactcc
ctgtctgaggaacccgagatccgggccttcgaccccgacgctgcggccgtgcagccttac
caggaccagacctaccagtctgtctactttgtgtccgaaagtttcagcgatgccaaggac
aagctcaggaactacgcttcccgcatccagcgccccttctccgtgaagttcgacccgtat
acactggccatcgacgtgctggacagtccccacgcgatccggcgctccctggagggcgtc
caggaggagctgcacacgctcgcacacgcgctgagcgccatcagctag

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (10)   
   KEGG PATHWAY (9)   
   KEGG MODULE (1)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (4)   
   Pfam (4)   
All databases (34)   

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