KEGG   Ursus maritimus (polar bear): 103676308Help
Entry
103676308         CDS       T03271                                 

Gene name
INSR
Definition
(RefSeq) insulin receptor
  KO
K04527  
insulin receptor [EC:2.7.10.1]
Organism
umr  Ursus maritimus (polar bear)
Pathway
MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phospholipase D signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Longevity regulating pathway
Longevity regulating pathway - multiple species
Adherens junction
Insulin signaling pathway
Ovarian steroidogenesis
Regulation of lipolysis in adipocytes
Type II diabetes mellitus
Insulin resistance
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Module
PI3K-Akt signaling
Brite
KEGG Orthology (KO) [BR:umr00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    103676308 (INSR)
   04015 Rap1 signaling pathway
    103676308 (INSR)
   04010 MAPK signaling pathway
    103676308 (INSR)
   04066 HIF-1 signaling pathway
    103676308 (INSR)
   04068 FoxO signaling pathway
    103676308 (INSR)
   04072 Phospholipase D signaling pathway
    103676308 (INSR)
   04022 cGMP - PKG signaling pathway
    103676308 (INSR)
   04151 PI3K-Akt signaling pathway
    103676308 (INSR)
   04152 AMPK signaling pathway
    103676308 (INSR)
   04150 mTOR signaling pathway
    103676308 (INSR)
 Cellular Processes
  Cellular community - eukaryotes
   04520 Adherens junction
    103676308 (INSR)
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    103676308 (INSR)
   04923 Regulation of lipolysis in adipocyte
    103676308 (INSR)
   04913 Ovarian Steroidogenesis
    103676308 (INSR)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    103676308 (INSR)
  Aging
   04211 Longevity regulating pathway - mammal
    103676308 (INSR)
   04213 Longevity regulating pathway - multiple species
    103676308 (INSR)
 Human Diseases
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    103676308 (INSR)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    103676308 (INSR)
   04931 Insulin resistance
    103676308 (INSR)
Enzymes [BR:umr01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     103676308 (INSR)
Protein kinases [BR:umr01001]
 Tyrosine protein kinases
  InsR family [OT]
   103676308 (INSR)
Enzyme-linked receptors [BR:umr01020]
 Receptor tyrosine kinases
  RTK class II (Insulin receptor family)
   103676308 (INSR)
Cytokine receptors [BR:umr04050]
 Receptor tyrosine kinase
  RTK class II (Insulin receptor family)
   103676308 (INSR)
CD molecules [BR:umr04090]
 Proteins
  103676308 (INSR)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
Position
Un
AA seq 1392 aa AA seqDB search
MGKQGVCAGEIRLHTREAGPATHSYNPSIACLLTCLAFCLFSLLVCPGMDIRNNLTRLHE
LANCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVI
RGSRLFFNYALVIFEMVHLKELGLYSLMNITRGSVRIEKNNELCYLATIDWSRILDSVED
NYIVLNKDDNEECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCT
AEGLCCHSECLGNCSEPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDL
HNKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLMCTPCLGPCPKVCHILEGEKTID
SVTSAQELRGCTVVNGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFF
RKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKM
EEVSGTKGRQERNDIALKTNGDQASCENELLKFSYIRTSYDKILLKWEPYWPPDFRDLLG
FMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQY
AIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPN
GNITHYLVFWERQAEDSELYELDYCLKGLKLPSRTWSPPFEAEGSQKHNQSEYEESAGEC
CSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRKSSSSPGAEDTRPSRKRRALGDVAN
VTAAPPTVPGFPNTSTSAPTSPEEHKPFEKVVNKESLVISGLRHFTGYRIELQACNQDSP
EERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRR
YGDEELHLCVSRRHFALERGCRLRGLPPGNYSVRVRATSLAGNGSWTEATYFYVTDYLDV
PSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSV
YVPDEWEVPREKITLLRELGQGSFGMVYEGNARDVVKGEAETRVAVKTVNESASLRERIE
FLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMAEDGVSWLRGPGKAPAPSRRNNPGRPP
PTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYY
RKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVM
DGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVDLLKDDLHPSFPEVSFFHSEENK
APESEELEMEFEDMESVPLDRASHSQREEAGGRDGGSSLGLKRNYEEHIPYTHMNGGKKN
GRILTLPRSNPS
NT seq 4179 nt NT seq  +upstreamnt  +downstreamnt
atgggcaagcagggtgtctgtgcaggggagatcaggttacacacccgtgaagctggccct
gccactcactcttataacccatccatcgcatgtttgctcacctgtcttgctttctgcttg
ttttcacttctagtgtgtcctggcatggatatccggaacaacctcacgaggttgcatgag
ctggccaactgctcagtcatcgaaggacatttgcagatactgttgatgttcaaaacgagg
cccgaggatttccgagacctcagtttccccaaactcatcatgatcaccgattacttgctg
ctcttccgggtctacgggctggagagcctgaaggacctgttccccaacctcacggtcatc
cggggctcgcgcctcttcttcaactacgcgctggtcatcttcgagatggttcacctgaag
gagcttggcctctatagcttgatgaacattaccaggggctccgtccgcatcgagaagaat
aatgagctctgctacctggccaccatcgactggtcacgcatcctggattccgtggaggat
aattacattgtgctgaacaaagacgacaatgaggagtgtggggacatctgtccaggcact
gcaaagggcaagaccaactgcccggccactgtcatcaacgggcagtttgtcgagaggtgt
tggacacacagccactgccagaaagtttgtcccaccatctgcaagtcgcacggctgcacc
gccgagggcctctgctgccacagcgagtgtttaggcaattgctccgagcccgatgacccc
accaagtgcgtggcctgtcgcaacttctacctggatggcaggtgcgtggagacctgcccg
cccccgtactaccacttccaagactggcgctgcgtgaacttcagcttctgccaggatttg
cacaacaaatgcaagaactcccggagacagggctgccaccagtacgtcattcacaataac
aagtgcatccccgagtgcccctctggctacacgatgaattccagcaacctgatgtgcacc
ccatgcctgggcccctgtcccaaggtctgccacatcctggagggcgagaagaccatcgac
tcggtgacctctgcccaggagcttcgaggctgcactgttgtcaacggaagcctcatcatc
aacattcgagggggcaacaacctggcagctgagctggaggccaacctcggactcattgaa
gaaatttccgggtatctgaaaatccggagatcctacgctcttgtgtccctttcctttttc
cggaagttacggctgattcgaggagagaccttggaaatcgggaactactctttctacgcc
ttggacaaccagaacctaaggcagctgtgggactggagcaaacacaacctcaccatcact
caggggaagctcttcttccactataatcccaaactctgcttgtcggaaattcacaagatg
gaggaagtttcaggaaccaaggggcgccaggagaggaacgacattgccctgaagaccaat
ggggaccaggcgtcttgtgaaaacgaactccttaaattttcttacattcggacatcatat
gacaagatcttgctgaaatgggagccatactggccccctgacttccgagacctcctgggc
ttcatgcttttctacaaagaggccccttatcagaatgtgaccgagttcgacgggcaggac
gcgtgtggctccaacagctggacggtggtggacattgacccgcctttgcggtccaatgac
cccaagtcacagaaccacccagggtggctgatgcggggtctcaagccctggacccagtat
gccatctttgtcaagaccttggtcaccttttctgatgaacgccgcacgtacggggccaag
agtgacatcatctatgtgcagacagatgccactaacccttccgtccccctggatccaatc
tccgtctcgaattcctcatcccagattattctgaagtggaagcctccctctgaccccaat
ggcaacatcacacactacctggttttctgggagaggcaggcagaagacagtgagctgtat
gaattggattattgcctcaaagggttgaagctgccctcccgcacctggtctccgccgttc
gaggccgagggctcgcagaagcacaaccagagtgagtacgaggagtctgccggcgagtgc
tgttcctgccccaagacggactctcagatcctcaaggagctggaggagtcctcgttcagg
aagaccttcgaggattacctgcacaatgtggtgttcgtccccagaaaatcctcttcaagc
cctggtgctgaggacactaggccatcgcggaaacgcagggccctcggtgacgttgccaat
gtgacggcggccccgcccacggttccgggtttccccaacacctccaccagcgcacccacg
agcccggaggagcacaagcccttcgagaaagtggtgaacaaggaatccctggtcatctct
gggctgcgtcacttcactggctaccgcatcgagctgcaggcttgcaaccaagactcccca
gaggagaggtgcagcgtggcggcttatgtcagcgccaggaccatgcccgaagctaaggca
gacgacattgttggccccgtgacccacgaaatcttcgagaacaacgttgttcacttgatg
tggcaggagccaaaggagcccaacggtctgatcgtgttgtatgaagtgagttaccgacgc
tacggtgatgaggagttgcacctctgtgtctcccgcagacactttgctctggagcggggc
tgcaggctgcgcgggctgccgccggggaattacagcgtgcgagtccgggccacctccctg
gccggcaacggctcctggacagaagccacttacttctacgtgacagactatttagatgtc
ccatcgaatattgcaaaaatcatcatcggccccctcatctttgtctttctcttcagtgtt
gtgattggaagtatttacctgttcctgagaaagaggcagccggatgggccactgggaccg
ctgtatgcttcttcaaaccctgagtacctcagtgcgagtgatgtgtttccatgttctgtg
tatgtgccggacgagtgggaggtcccccgggagaagatcactctgctgcgtgagctgggg
cagggctccttcggcatggtgtacgaaggcaacgccagagacgtcgtcaagggcgaggcg
gagacccgcgtggcggtgaagacggtcaatgagtcggccagtctgcgggagaggatcgag
tttctcaacgaggcctcggtcatgaagggcttcacctgtcatcacgtggtccgcctcctg
ggggtggtgtccaagggccagccgacgctggtggtgatggcggaggatggggtgagctgg
ctccggggacccggcaaggcgcccgctcccagccgccggaataaccccggccgccctccc
cctaccctgcaagagatgattcagatggcggcggagatcgccgacgggatggcctacctg
aacgccaagaagttcgtgcaccgggatctcgcggcccgaaactgcatggtcgcccacgac
ttcaccgtcaaaattggagactttgggatgaccagagacatctatgaaacggattactac
cggaaaggaggcaagggtctgctccccgtgcggtggatggccccggaatcgctgaaggac
ggggtctttaccacttcttctgacatgtggtcctttggcgtggtcctttgggaaatcacc
agcttggcagaacagccataccagggtctgtctaatgaacaggtgttgaaattcgtcatg
gatggagggtatctggatcaacccgacaattgtccagagagagtcaccgacctgatgcgc
atgtgctggcagttcaatcccaagatgcggcccaccttcctggagatcgtcgacctgctc
aaggacgacctgcaccccagctttccggaagtttccttcttccatagcgaggagaacaag
gcgcctgagagcgaggagctggagatggagttcgaggacatggagagtgtccccctggat
cgggcctcacactctcagagggaggaggccgggggccgggatggagggtcctccctgggc
ctcaagcgaaactacgaggagcacatcccctacacccacatgaacgggggcaagaaaaac
ggacggattctgactctgccgaggtcgaatccttcctaa

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