ID HXA3_MOUSE Reviewed; 443 AA.
AC P02831; Q4V9Z8; Q61197;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 19-JAN-2010, entry version 97.
DE RecName: Full=Homeobox protein Hox-A3;
DE AltName: Full=Hox-1.5;
DE AltName: Full=MO-10;
GN Name=Hoxa3; Synonyms=Hox-1.5, Hoxa-3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muroidea; Muridae; Murinae; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/c;
RA Hofmann M., Boehm T.;
RL Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 54-280.
RC STRAIN=ICR X Swiss Webster;
RX MEDLINE=96323206; PubMed=8710855; DOI=10.1073/pnas.93.16.8247;
RA Tan D.-P., Shao X., Pu L., Guo V., Nirenberg M.;
RT "Sequence and expression of the murine Hoxd-3 homeobox gene.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:8247-8252(1996).
RN [4]
RP NUCLEOTIDE SEQUENCE OF 185-258.
RA Ruddle F.H., Hart C.P., McGinnis W.;
RT "Structural and functional aspects of the mammalian homeo-box
RT sequences.";
RL Trends Genet. 1:48-51(1985).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 185-258.
RX MEDLINE=85024859; PubMed=6091896; DOI=10.1016/0092-8674(84)90262-9;
RA McGinnis W., Hart C.P., Gehring W.J., Ruddle F.H.;
RT "Molecular cloning and chromosome mapping of a mouse DNA sequence
RT homologous to homeotic genes of Drosophila.";
RL Cell 38:675-680(1984).
RN [6]
RP DNA-BINDING.
RX MEDLINE=87092283; PubMed=2879282; DOI=10.1073/pnas.83.24.9532;
RA Fainsod A., Bogarad L.D., Ruusala T., Lubin M., Crothers D.M.,
RA Ruddle F.H.;
RT "The homeo domain of a murine protein binds 5' to its own homeo box.";
RL Proc. Natl. Acad. Sci. U.S.A. 83:9532-9536(1986).
RN [7]
RP DEVELOPMENTAL STAGE.
RX MEDLINE=88030407; PubMed=2444477; DOI=10.1016/0012-1606(87)90465-9;
RA Fainsod A., Awgulewitsch A., Ruddle F.H.;
RT "Expression of the murine homeo box gene Hox 1.5 during
RT embryogenesis.";
RL Dev. Biol. 124:125-133(1987).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of
CC a developmental regulatory system that provides cells with
CC specific positional identities on the anterior-posterior axis.
CC Binds 5' to its own homeobox.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- DEVELOPMENTAL STAGE: Expressed in a spatially restricted manner in
CC embryos 8.5 dpc, expression is limited to the CNS with an anterior
CC boundary in the hindbrain and extending posteriorly through caudal
CC regions of the spinal cord. The same spatial expression is seen in
CC embryos 9.5 to 12.5 dpc.
CC -!- SIMILARITY: Belongs to the Antp homeobox family.
CC -!- SIMILARITY: Contains 1 homeobox DNA-binding domain.
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DR EMBL; Y11717; CAA72404.1; -; mRNA.
DR EMBL; BC096612; AAH96612.1; -; mRNA.
DR EMBL; U56399; AAC52778.1; -; mRNA.
DR EMBL; K02591; AAA37822.1; -; Genomic_DNA.
DR IPI; IPI00113737; -.
DR PIR; I49746; I49746.
DR RefSeq; NP_034582.1; -.
DR UniGene; Mm.159945; -.
DR SMR; P02831; 155-246, 192-251.
DR STRING; P02831; -.
DR PRIDE; P02831; -.
DR Ensembl; ENSMUST00000048882; ENSMUSP00000043008; ENSMUSG00000079560; Mus musculus.
DR Ensembl; ENSMUST00000114434; ENSMUSP00000110077; ENSMUSG00000079560; Mus musculus.
DR Ensembl; ENSMUST00000118397; ENSMUSP00000113224; ENSMUSG00000079560; Mus musculus.
DR GeneID; 15400; -.
DR KEGG; mmu:15400; -.
DR UCSC; uc009bya.1; mouse.
DR CTD; 15400; -.
DR MGI; MGI:96175; Hoxa3.
DR eggNOG; roNOG04624; -.
DR HOGENOM; HBG445573; -.
DR HOVERGEN; P02831; -.
DR InParanoid; P02831; -.
DR OMA; YDSSAIY; -.
DR OrthoDB; EOG9HHRMP; -.
DR PhylomeDB; P02831; -.
DR NextBio; 288094; -.
DR ArrayExpress; P02831; -.
DR Bgee; P02831; -.
DR CleanEx; MM_HOXA3; -.
DR Genevestigator; P02831; -.
DR GermOnline; ENSMUSG00000059723; Mus musculus.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0003700; F:transcription factor activity; IEA:InterPro.
DR GO; GO:0009952; P:anterior/posterior pattern formation; IGI:MGI.
DR GO; GO:0001974; P:blood vessel remodeling; IMP:MGI.
DR GO; GO:0051216; P:cartilage development; IGI:MGI.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; IGI:MGI.
DR GO; GO:0021615; P:glossopharyngeal nerve morphogenesis; IGI:MGI.
DR GO; GO:0048645; P:organ formation; IMP:MGI.
DR GO; GO:0060017; P:parathyroid gland development; IGI:MGI.
DR GO; GO:0008284; P:positive regulation of cell proliferation; IMP:MGI.
DR GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.
DR GO; GO:0010159; P:specification of organ position; IGI:MGI.
DR GO; GO:0048538; P:thymus development; IMP:MGI.
DR GO; GO:0030878; P:thyroid gland development; IMP:MGI.
DR GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR InterPro; IPR001356; Homeobox.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR020479; Homeobox_region.
DR InterPro; IPR009057; Homeodomain-like.
DR InterPro; IPR012287; Homeodomain-rel.
DR Gene3D; G3DSA:1.10.10.60; Homeodomain-rel; 1.
DR Pfam; PF00046; Homeobox; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Transcription;
KW Transcription regulation.
FT CHAIN 1 443 Homeobox protein Hox-A3.
FT /FTId=PRO_0000200044.
FT DNA_BIND 192 251 Homeobox.
FT MOTIF 156 161 Antp-type hexapeptide.
FT COMPBIAS 79 138 Pro-rich.
FT CONFLICT 185 185 S -> G (in Ref. 4 and 5).
FT CONFLICT 195 195 A -> G (in Ref. 4 and 5).
FT CONFLICT 201 202 SA -> RP (in Ref. 4 and 5).
FT CONFLICT 218 218 C -> M (in Ref. 4 and 5).
SQ SEQUENCE 443 AA; 46430 MW; 6C0E184B0F6F2D40 CRC64;
MQKATYYDSS AIYGGYPYQA ANGFAYNASQ QPYAPSAALG TDGVEYHRPA CSLQSPASAG
GHPKTHELSE ACLRTLSGPP SQPPGLGEPP LPPPPPQAAP PAPQPPQPPP QPPAPTPAAP
PPPSSVSPPQ SANSNPTPAS TAKSPLLNSP TVGKQIFPWM KESRQNTKQK TSGSSSGESC
AGDKSPPGQA SSKRARTAYT SAQLVELEKE FHFNRYLCRP RRVEMANLLN LTERQIKIWF
QNRRMKYKKD QKGKGMLTSS GGQSPSRSPV PPGAGGYLNS MHSLVNSVPY EPQSPPPFSK
PPQGAYGLPP ASYPAPLPSC APPPPPQKRY TAAGSGAGGT PDYDPHAHGL QGNGSYGTPH
LQGSPVFVGG SYVEPMSNSG PLFGLTHLPH TTSAAMDYGG TGPLGSGHHH GPGPGEPHPT
YTDLTAHHPS QGRIQEAPKL THL
//
