ID A0A010YQ44_9ACTN Unreviewed; 574 AA.
AC A0A010YQ44;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Thiamine pyrophosphate-dependent enzyme, putative carboligase or decarboxylase {ECO:0000313|EMBL:EXG82295.1};
GN ORFNames=CryarDRAFT_3461 {ECO:0000313|EMBL:EXG82295.1};
OS Cryptosporangium arvum DSM 44712.
OC Bacteria; Actinomycetota; Actinomycetes; Cryptosporangiales;
OC Cryptosporangiaceae; Cryptosporangium.
OX NCBI_TaxID=927661 {ECO:0000313|EMBL:EXG82295.1, ECO:0000313|Proteomes:UP000021053};
RN [1] {ECO:0000313|EMBL:EXG82295.1, ECO:0000313|Proteomes:UP000021053}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44712 {ECO:0000313|EMBL:EXG82295.1,
RC ECO:0000313|Proteomes:UP000021053};
RG DOE Joint Genome Institute;
RA Eisen J., Huntemann M., Han J., Chen A., Kyrpides N., Mavromatis K.,
RA Markowitz V., Palaniappan K., Ivanova N., Schaumberg A., Pati A.,
RA Liolios K., Nordberg H.P., Cantor M.N., Hua S.X., Woyke T.;
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- SIMILARITY: Belongs to the TPP enzyme family.
CC {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EXG82295.1}.
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DR EMBL; JFBT01000001; EXG82295.1; -; Genomic_DNA.
DR RefSeq; WP_035851984.1; NZ_KK073874.1.
DR AlphaFoldDB; A0A010YQ44; -.
DR PATRIC; fig|927661.3.peg.3422; -.
DR HOGENOM; CLU_013748_3_1_11; -.
DR OrthoDB; 4494979at2; -.
DR Proteomes; UP000021053; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR CDD; cd00568; TPP_enzymes; 1.
DR CDD; cd07035; TPP_PYR_POX_like; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR InterPro; IPR000399; TPP-bd_CS.
DR InterPro; IPR045229; TPP_enz.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR PANTHER; PTHR18968:SF13; ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL; 1.
DR PANTHER; PTHR18968; THIAMINE PYROPHOSPHATE ENZYMES; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR Pfam; PF00205; TPP_enzyme_M; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR PROSITE; PS00187; TPP_ENZYMES; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000313|EMBL:EXG82295.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000021053};
KW Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT DOMAIN 4..115
FT /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02776"
FT DOMAIN 196..333
FT /note="Thiamine pyrophosphate enzyme central"
FT /evidence="ECO:0000259|Pfam:PF00205"
FT DOMAIN 397..550
FT /note="Thiamine pyrophosphate enzyme TPP-binding"
FT /evidence="ECO:0000259|Pfam:PF02775"
SQ SEQUENCE 574 AA; 61093 MW; CD6B3AF434E7CDA6 CRC64;
MTTTAAAALT AQLESYGVEY VFGTCGHTNI ALLDALGRSS IEFVIARHEQ AAAHAADGYA
RASGKPGVVL LHVGPGMMNA VTGVATAALD SVPLIAIAGD IPSYYHGRHP HQEVNLHNDA
DQTAIYRPFV KRAWHVQRVE DLPRFTERAF TTAVSGRPGA VLLDVPMDLF SRPQTAESYP
MPGELTRPDL PEGTAERIAD ALVAAERPLI YVGGGLSAGP GREALTALVE HLDIPVAHSL
MAKGSLPDDH PLVMGMPGFW GLEETNRYAR EADVVLAIAT RFAETDASSW NDRYTWSFPP
TRLIQIDIDP AELGRNFPVE IGAVADAALA MRRIAAAALR RPEASRPALR ESITAARGAL
FAGSAERGRS DDFPLRPERI LLDLRETLPA DTVLVTDVGW NKNGVAQAYP LPVEGRFITP
GGASTMGFGP AAALGVQIAW PDRPVVALIG DGGMSAQLPA LPMAVERGLP VLFVVMNNQA
HGTIADLQAA NFGAGYGCEF TDADGNPYSP DFAALGQACG ADGYRIEEPG DLRKALHAAL
ANRRPAVLDV PMVNEPVPTP GHWNIKDIYA GIFE
//
