ID A0A011MU16_9PROT Unreviewed; 910 AA.
AC A0A011MU16;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN Name=kdpD {ECO:0000313|EMBL:EXI66036.1};
GN ORFNames=AW08_02775 {ECO:0000313|EMBL:EXI66036.1};
OS Candidatus Accumulibacter adjunctus.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Candidatus Accumulibacter.
OX NCBI_TaxID=1454001 {ECO:0000313|EMBL:EXI66036.1, ECO:0000313|Proteomes:UP000020218};
RN [1] {ECO:0000313|EMBL:EXI66036.1, ECO:0000313|Proteomes:UP000020218}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SK-12 {ECO:0000313|Proteomes:UP000020218};
RA Skennerton C.T., Barr J.J., Slater F.R., Bond P.L., Tyson G.W.;
RT "Expanding our view of genomic diversity in Candidatus Accumulibacter
RT clades.";
RL Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EXI66036.1}.
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DR EMBL; JFAX01000017; EXI66036.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A011MU16; -.
DR STRING; 1454001.AW08_02775; -.
DR PATRIC; fig|1454001.3.peg.2827; -.
DR Proteomes; UP000020218; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00075; HATPase; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd01987; USP_OKCHK; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.20.120.620; Backbone structure of the membrane domain of e. Coli histidine kinase receptor kdpd; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR038318; KdpD_sf.
DR InterPro; IPR025201; KdpD_TM.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR003852; Sig_transdc_His_kinase_KdpD_N.
DR PANTHER; PTHR45569; SENSOR PROTEIN KDPD; 1.
DR PANTHER; PTHR45569:SF1; SENSOR PROTEIN KDPD; 1.
DR Pfam; PF13493; DUF4118; 1.
DR Pfam; PF13492; GAF_3; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF02702; KdpD; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000020218};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EXI66036.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 410..430
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 442..468
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 488..507
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 682..897
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 910 AA; 99826 MW; 98E05FB154BFCA47 CRC64;
MAPQLGREMK DGRPDPDLIL DRIKEEEMRA ARGKLKIFFG ASAGVGKTYA MLSAARQQAE
QGTDVVIGVV ETHGRKETEA LLTGLERLPL QAVAYRDRVL PEFDIDGALA RKPALLLVDE
LAHSNVPGSR HAKRWQDVEE LQSSGIDVYS TVNVQHLETL NDVVGGITGI RVWETVPDHV
FDAADEVVLV DLTPDELLQR LKEGKVYLPQ QAERAIQNFF RKGNLIALRE LALRRTADRV
DSEMIQYRRD RSVTRAWHTS ESLLACIGPG DGSDRIIRSA ARIATKLDVP WHVIYVETPK
LRHLSDQRRL QILKSLKLAQ EMGAETASLP GSDAMATIID YARDHNLSKL LVGRDRAQAW
RPWKRSFADR VGKLAPDLDI IQVARVDTPA DRRQEESTGE SLLDRLHAPW QSFAMSSVFC
ALVTLIAMPL HTVFDRANIA MLFLMAVVLS AVRYGLGPAV AAAFLNVAAF DFFFVPPRFS
FAVGDVQYLM TFAVMLAVGL VTAKLTADLK FQARVASRRE QRVRALYEMS RDLSGALMPE
QIAEISQRFA ATGFGARAAI MLADERDRLH EAIPVPGGVP AVDVGISQWA FDHSAEAGWG
TDTLAGSPLL YVPLKAPMRT RGVLVLEPKH SRRLLAPEQR RLLDTFARLV AISLERVHYV
DVARATTVQM ESERLRNSLL SAISHDLRTP LAALVGLADS MSMTQPPPTG EQCDIAASMR
DEALRMNSLV NNLLDMARLQ AGAVKLNRQW QPLEEVVGSA IKAMRSTMAG HRLGVNLPDG
LPLLEFDAVL VERVLCNLLE NAVTYTPAGS LIEIGAAPGA RDQVDIWVED DGPGLPAGKE
ELIFSKFERG QKESAASGVG LGLAICRAIV TAHGGTIRAE NRRGGGARFV FSLPRGQPPS
LAGAEEDSPQ
//
