ID A0A011NQP2_9PROT Unreviewed; 427 AA.
AC A0A011NQP2;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Methionine gamma-lyase {ECO:0000313|EMBL:EXI66835.1};
DE EC=4.4.1.11 {ECO:0000313|EMBL:EXI66835.1};
GN Name=mdeA_1 {ECO:0000313|EMBL:EXI66835.1};
GN ORFNames=AW08_02422 {ECO:0000313|EMBL:EXI66835.1};
OS Candidatus Accumulibacter adjunctus.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Candidatus Accumulibacter.
OX NCBI_TaxID=1454001 {ECO:0000313|EMBL:EXI66835.1, ECO:0000313|Proteomes:UP000020218};
RN [1] {ECO:0000313|EMBL:EXI66835.1, ECO:0000313|Proteomes:UP000020218}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SK-12 {ECO:0000313|Proteomes:UP000020218};
RA Skennerton C.T., Barr J.J., Slater F.R., Bond P.L., Tyson G.W.;
RT "Expanding our view of genomic diversity in Candidatus Accumulibacter
RT clades.";
RL Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|RuleBase:RU362118};
CC -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC {ECO:0000256|ARBA:ARBA00009077, ECO:0000256|RuleBase:RU362118}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EXI66835.1}.
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DR EMBL; JFAX01000013; EXI66835.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A011NQP2; -.
DR STRING; 1454001.AW08_02422; -.
DR PATRIC; fig|1454001.3.peg.2464; -.
DR Proteomes; UP000020218; Unassembled WGS sequence.
DR GO; GO:0018826; F:methionine gamma-lyase activity; IEA:UniProtKB-EC.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0016765; F:transferase activity, transferring alkyl or aryl (other than methyl) groups; IEA:InterPro.
DR GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR CDD; cd00614; CGS_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR InterPro; IPR006235; OAc-hSer/O-AcSer_sulfhydrylase.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR NCBIfam; TIGR01326; OAH_OAS_sulfhy; 1.
DR PANTHER; PTHR43797; HOMOCYSTEINE/CYSTEINE SYNTHASE; 1.
DR PANTHER; PTHR43797:SF2; HOMOCYSTEINE_CYSTEINE SYNTHASE; 1.
DR Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR PIRSF; PIRSF001434; CGS; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR PROSITE; PS00868; CYS_MET_METAB_PP; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000313|EMBL:EXI66835.1};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR001434-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000020218}.
FT MOD_RES 204
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ SEQUENCE 427 AA; 45806 MW; 9B7277EEA3B6E7C5 CRC64;
MKLETLAVHA GYSPEPTTKA VAVPIYQTTS YSFDSTQHGA DLFDLKVAGN IYTRIMNPTQ
DVLEKRVAAM EGGIGGLALA SGQAAITYAI MTIAEAGDNI VSASTLYGGT YNLFAHTLPQ
YGIEVRFANH ADPASFERLI NGRTKALYCE SVGNPLGNIT DFEPLAEIAH RHGVPLIVDN
TVPSPYLCRP FEHGADIVVH SLTKYIGGHG NSIGGMIVDS GRFPWAEHKL KFRRLNEPDV
SYHGVVYTEA LGPAAFIGRA RVVPLRNMGA AISPMNSFLI LQGLETLPLR MDRICSNAEK
VAAYLRAHAK VAWVNYAGLA DHPDHPLVDK YMDGRASGIL TFGVQGSDCS GSVAGARFQD
ALQLFTRLVN IGDAKSLACH PASTTHRQLG AAELAKAGVS EEMIRLSIGI EHIDDLVADL
EQALAAV
//
