ID A0A014MDE7_9BURK Unreviewed; 780 AA.
AC A0A014MDE7;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=Competence protein ComEC {ECO:0000313|EMBL:EXU79751.1};
GN ORFNames=AX13_03645 {ECO:0000313|EMBL:EXU79751.1};
OS Comamonas aquatica DA1877.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Comamonas.
OX NCBI_TaxID=1457173 {ECO:0000313|EMBL:EXU79751.1, ECO:0000313|Proteomes:UP000020766};
RN [1] {ECO:0000313|EMBL:EXU79751.1, ECO:0000313|Proteomes:UP000020766}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DA1877 {ECO:0000313|EMBL:EXU79751.1,
RC ECO:0000313|Proteomes:UP000020766};
RA Watson E., Macneil L.T., Ritter A.D., Yilmaz L.S., Rosebrock A.P.,
RA Caudy A.A., Walhout A.J.;
RT "Interspecies Systems Biology Uncovers Metabolites Affecting C. elegans
RT Gene Expression and Life History Traits.";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EXU79751.1}.
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DR EMBL; JBOK01000013; EXU79751.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A014MDE7; -.
DR STRING; 225991.MA05_13660; -.
DR PATRIC; fig|1457173.3.peg.2397; -.
DR Proteomes; UP000020766; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0030420; P:establishment of competence for transformation; IEA:InterPro.
DR CDD; cd07731; ComA-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR035681; ComA-like_MBL.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR004797; Competence_ComEC/Rec2.
DR InterPro; IPR025405; DUF4131.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR NCBIfam; TIGR00360; ComEC_N-term; 1.
DR NCBIfam; TIGR00361; ComEC_Rec2; 1.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF13567; DUF4131; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000020766};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..38
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 251..274
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 286..310
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 330..348
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 355..374
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 394..418
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 425..447
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 467..490
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 530..714
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
SQ SEQUENCE 780 AA; 84894 MW; FD79DB30D10F1B99 CRC64;
MLGVVAGTAT QLQQAALLPW PVYAGWLAAA VLLGPLLWRR PAWRWGWLLW GAALAWGMTG
WRAASFAATA MPPAWEGRDV RVTGVITDMP QAVERGMRLR FAVEQAQSAE VPPQPVPLPP
QVALTWYGEL PPQGLQAGQR WAWTVRLKAP HGERNPHGMD WELWWWSQGI QATGYVRRGA
RDAPPQWLGQ TWQAPVARWR GQIHQRMQAP EGASARLQAS MGVVQALVTG AQSSIGRTDW
QLFRDTGVAH LVSISGLHIT MFAWLAMAVV QLCWRRSARL CLWQPAPVVA AWAGLALATA
YALFSGWGIP AQRTIGMLAV VVLLRSQARS WPWPCVWLTV LTVVVLIDPW SLLQAGFWLS
FVAVGVLFAA QPRLGGDTAR GWKPTLVRMA REQWIVGIAL APLTLLLFGQ VSVIGLLANL
WAIPWVTLVI TPLSMLGVLW SPLWWLAAQG VTAMVGLLDA MADWRGAVLF FAQPPWWAAL
AGVLGCLWLV MPWGWRWRML GLPLLVPLLG WQPQAPAWGH FEVLALDVGQ GSAALVRTQG
HSLLFDAGPQ WSEQANAGER TVVPVLRALG IAPDVLLVSH ADSDHAGGAE AVVAAFPRAH
RLGAGGVPCV RGQSWTWDGV QLEVLHPMAP ATHTPVGGAG RNAQSCVLRV RSVTGTVALL
TGDVEARQEQ ALLYAGSPLR ADLVLMPHHG SKTSSTVAWV QAVQPVVAIA QSGYRNRFGH
PHPAVVQRYQ AQGARTVTSA GCGAARWRSW APRAVQCERT LARRYWQHAV PEAAGAGYTE
//
