ID A0A016RYK5_9BILA Unreviewed; 783 AA.
AC A0A016RYK5;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EYB83034.1};
GN Name=Acey_s0345.g3127 {ECO:0000313|EMBL:EYB83034.1};
GN Synonyms=Acey-lov-1 {ECO:0000313|EMBL:EYB83034.1};
GN ORFNames=Y032_0345g3127 {ECO:0000313|EMBL:EYB83034.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYB83034.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYB83034.1}.
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DR EMBL; JARK01001681; EYB83034.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016RYK5; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR046791; Polycystin_dom.
DR PANTHER; PTHR10877:SF195; POLYCYSTIC KIDNEY DISEASE 1 LIKE 2A-RELATED; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR Pfam; PF20519; Polycystin_dom; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 61..84
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 96..119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 184..204
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 463..481
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 501..530
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 561..582
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 602..624
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 663..688
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 232..448
FT /note="Polycystin"
FT /evidence="ECO:0000259|Pfam:PF20519"
FT DOMAIN 506..691
FT /note="Polycystin cation channel PKD1/PKD2"
FT /evidence="ECO:0000259|Pfam:PF08016"
SQ SEQUENCE 783 AA; 89915 MW; 2A907F9EB0AA0524 CRC64;
MREEVAYALL LSIIILPFTS LLPLMKSKML SYDELREVEL IKSRDKDTKL PSYWPFALRE
ILQLLLTWLT IGFFILDVSL ACSLAEDASI AFTRRYVITL FFWIAITEPL KGMLCAYIIL
KKNPSHFISC EFDEAILPLD YVDNCKPAPE CLRNDVVGTT ESDLKQLQDN KDKKTREELF
FETMREVACL LASLVVIMGL VFYYRDNTGF LYQQQVRSLL NLEQIPYGPV AFGSINQIEQ
FWTWANDSLA PALLASWYDG GPAWAMRGFA NDKVSRAMGI GHIRQIRSVP LSQCYTVPQL
AAYSGNCTRD ITFGNEDRHP QYARGWKPYV EVDGVDPPAE YKYRTADEHQ SAYLFSFVTR
HAAVEGRLHS YGGGGYSVLL KGTPLQIQDT LKRLKQEHWI DKNTRVILVE LSMYNAQVNY
FAVVELVIEI PAEGYLLPSS WVEAVRLIKY QGRDGDIIMT FEFLYIAFAI FSFLKNTFYY
GTNVVNAFKT LPPKGGPIRN FLYILLGRFW DFVDFFVGIL AICSVIAFFL RQQYIEQALE
NFAANNGNAY INLSQQRNME LMFTFCVAGV VFFVSCKLIK ILRFNRRIAF LADTLDYAGV
SITDFAVVFV LIICAFNASL YCLLWNKLES YKSAVATFET TTAGMLGKFV VADIFQITML
GSIIFMIFMY TGTLFLINIF VMIVMYEFEQ VRNDSSRQTN QYEIIDHIQT KVLRSIGMYG
RENVPACYVR DSMKDYELLT TLTAKADLLL HRVLRWRINY DNDDDDIVLP PRRAQDMPDP
LYL
//
