ID A0A016S3N7_9BILA Unreviewed; 1103 AA.
AC A0A016S3N7;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Reverse transcriptase domain-containing protein {ECO:0000259|PROSITE:PS50878};
GN Name=Acey_s0301.g1829 {ECO:0000313|EMBL:EYB85285.1};
GN ORFNames=Y032_0301g1829 {ECO:0000313|EMBL:EYB85285.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYB85285.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYB85285.1}.
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DR EMBL; JARK01001637; EYB85285.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016S3N7; -.
DR STRING; 53326.A0A016S3N7; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR CDD; cd01650; RT_nLTR_like; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR19446:SF415; REVERSE TRANSCRIPTASE-RELATED PROTEIN; 1.
DR PANTHER; PTHR19446; REVERSE TRANSCRIPTASES; 1.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000024635}.
FT DOMAIN 477..731
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
SQ SEQUENCE 1103 AA; 127257 MW; A8F27FEFF871B74E CRC64;
MMTICTFNTR TLASEATIED LMVQARKIRC DVIGLTETRR HRPLNATFDT GEELFGTCDS
RGVGGVGVLV NTNLAMNIDS FELLTTRIGR LRLRRCGSMP ALTVFVAYAP TSSYDEDEIE
AFYMDLEKFY REDHTFYKVI VGDFNAKIGP RRTPEELHIG THGLQWNEQG ERLSEFIMTT
RTIHGNSQFQ KPTSLRWTWE SPGGEYHNEI DHIIVNRRYC LTDVGVVPKF YTGSDHRLLR
ARFFFSRKGE KAAKYKKRSP KPTINWDLFT TLAGFWEDTV VDNIDEEYER LIQHLRDSAK
KAEGLRTTKR RLSHETLELI RQRGAARAAG NYQLTSELAR RCREAIKEDL KERRAAVLAE
AAEAGRSIRN TRRDFANRKT KMTALRRPDG TITSSRRVME KVIYDFYSDL FDSHVHLPPC
HLREDEYVIP SVLPSEVRHA IKSVKNRTAP GPDRIRPEHL KNLPTALVNT LARLFTRYLS
ECKVPSQWKT SRTVLLYKKG DPQDIGNYRP ICLLSVVYKL FTRVILNRIE RTLDEGQPCE
QAGFRKGFST IDHIHTVTRL IEVSREYKMP LCLTFIDLKK AFDTVETEAV LEALGNQGVP
TQYIRIFREL YSNFTTRISP FYDDITIDVR RGVRQGDTVS PKLFTATLED VMRRLEWDNM
GVRVDGRLLH HLRFADDIVL ITPSISQAER MLADFDDACG KIGLQLNLTK TMFMRNGWVP
DAPFSLNGTT ISECSSYVYL GREVNMMNDL APELGRRKRA AWGAYKSIED VVKKTKNIRL
RAHLFNTTVL PALTYASETW ALRKQDENAV SVIERSIERV MLGMTRLTQV RAGIRSSTLR
QQSKIRDAAV YAKSSKIRWA GHVMRLNDHR WTRAVSDWTP RNVKRTTGRP PTRWSDFFTK
SFKERYDALR VSRTNRTHLT TLARERDKWK DCWRPLGLPD DQRESSIFRE SQNVWILSSL
FLNLTGLSSP QPVVTTLCCA LVILAICPCG YQCNQGIGTK FESRRSNRKE EGDKRSQVHT
YCSPLCYSFS SRKNNINMMI AVSDRRLVYW RPMYVLNCIP IRSAKDKESR RIKEDKKCAG
LSSRVVWQDL QDFIEECGNE DPK
//
