ID   A0A016S7K3_9BILA        Unreviewed;       408 AA.
AC   A0A016S7K3;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=Thioredoxin domain-containing protein {ECO:0000259|PROSITE:PS51352};
GN   Name=Acey_s0279.g1209 {ECO:0000313|EMBL:EYB86436.1};
GN   ORFNames=Y032_0279g1209 {ECO:0000313|EMBL:EYB86436.1};
OS   Ancylostoma ceylanicum.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=53326 {ECO:0000313|EMBL:EYB86436.1, ECO:0000313|Proteomes:UP000024635};
RN   [1] {ECO:0000313|Proteomes:UP000024635}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX   PubMed=25730766; DOI=10.1038/ng.3237;
RA   Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA   Aroian R.V.;
RT   "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT   ceylanicum identify infection-specific gene families.";
RL   Nat. Genet. 47:416-422(2015).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EYB86436.1}.
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DR   EMBL; JARK01001615; EYB86436.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A016S7K3; -.
DR   Proteomes; UP000024635; Unassembled WGS sequence.
DR   Gene3D; 3.40.30.10; Glutaredoxin; 3.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   PANTHER; PTHR46295; ENDOPLASMIC RETICULUM RESIDENT PROTEIN 44; 1.
DR   PANTHER; PTHR46295:SF4; ENDOPLASMIC RETICULUM RESIDENT PROTEIN 44.2; 1.
DR   Pfam; PF00085; Thioredoxin; 1.
DR   Pfam; PF13848; Thioredoxin_6; 1.
DR   SUPFAM; SSF52833; Thioredoxin-like; 2.
DR   PROSITE; PS51352; THIOREDOXIN_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           17..408
FT                   /note="Thioredoxin domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5001486470"
FT   DOMAIN          9..128
FT                   /note="Thioredoxin"
FT                   /evidence="ECO:0000259|PROSITE:PS51352"
FT   REGION          364..390
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        364..378
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   408 AA;  47336 MW;  4632E32C67C4ED3C CRC64;
     MRELVVLAIS IHLALPNDVA FMTSDNADEL LKKHQLVFVS FGADWCPYSQ ALRPIFNEAA
     TKFKQDNPLA DVLWVYVDCV MEAEVCTRFF ISKYPTMKVF VYGDMMKNEY RSSRTVDSLV
     AFVAGHYAGS VKEFHKHEDL SKRMDKSRRN VVAYVKRGGE EYKNIYNLAL LLRDYCDIWV
     PAVGTLLSDT ETRLYYVPPD NERTTDFVGD IKNYTYLKQW LSDKCIPLVR EVTFENVEGL
     TEEGLPFLIY FRDPAKKDDE KVFTDAVVRE LYDQRMSINP LLADGMKFVH PLRHLGKTTK
     DLPVLAIDSF VHMYLFPDIS QLSQPGVLKQ FVEDLHSGAL HKRFHQEAEI KRVELEKFKK
     EHNIEADLED RREEQNPVEP VKTAPPESVF KELKPSEKRY SLLQKTEL
//