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Database: UniProt
Entry: A0A016S8K6_9BILA
LinkDB: A0A016S8K6_9BILA
Original site: A0A016S8K6_9BILA 
ID   A0A016S8K6_9BILA        Unreviewed;       502 AA.
AC   A0A016S8K6;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   25-OCT-2017, entry version 10.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=Acey_s0275.g1067 {ECO:0000313|EMBL:EYB86677.1};
GN   ORFNames=Y032_0275g1067 {ECO:0000313|EMBL:EYB86677.1};
OS   Ancylostoma ceylanicum.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Strongylida; Ancylostomatoidea; Ancylostomatidae; Ancylostomatinae;
OC   Ancylostoma.
OX   NCBI_TaxID=53326 {ECO:0000313|EMBL:EYB86677.1, ECO:0000313|Proteomes:UP000024635};
RN   [1] {ECO:0000313|Proteomes:UP000024635}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX   PubMed=25730766; DOI=10.1038/ng.3237;
RA   Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA   Aroian R.V.;
RT   "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT   ceylanicum identify infection-specific gene families.";
RL   Nat. Genet. 47:416-422(2015).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EYB86677.1}.
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DR   EMBL; JARK01001611; EYB86677.1; -; Genomic_DNA.
DR   Proteomes; UP000024635; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   PANTHER; PTHR11629; PTHR11629; 2.
DR   Pfam; PF01496; V_ATPase_I; 2.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000024635};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    233    257       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    278    296       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    370    389       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    410    429       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   502 AA;  57359 MW;  068ADF8E7815D216 CRC64;
     MATSEEDAHS HPGMQSDNAP LKIQLRFVAG VIRRERLPAF ERLLWRACRG NVFLRTSEID
     DVLNDTVTGE PVNKTVFIIF FQGDQLKTKV KKICEGFRAT LYPCPDTPQE RREMSIGVMT
     RIEDLKTVLG QTQDHRHRVL VAASKNVRMW LTKVRKIKSI YHTLNLFNID VTHEESGSQV
     PSILNRMETT EAPPTYHKTN KFTRGFQNIV DAYGIATYRE INPAPYTMIS FPFLFAVMFG
     DLGHGTIMLL AALFFILKEK QLEAARIKDE IFQTFFGGRY VIFLMGAFSI YTGLLYNDVF
     SKSLNIFGSG WTNCYDLQQI ARLGYGPEKN LMLIPEKAYD DAAGPYPIGV DPVWNLAESN
     KLNFLNSLKM KLSVILGITQ MTFGVLLSYQ NYKYFKSDLD IKFMFIPQMI FLACIFIYLC
     LEIVVKWIWF TAGPQDSIFG YKYPGSNCAP SLLIGLINMF MMKTMGTGFV EEDGSQKFQC
     YLNNWYPGQV LFSTVVYSYF AA
//
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