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Database: UniProt
Entry: A0A016S8T5_9BILA
LinkDB: A0A016S8T5_9BILA
Original site: A0A016S8T5_9BILA 
ID   A0A016S8T5_9BILA        Unreviewed;       536 AA.
AC   A0A016S8T5;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   05-OCT-2016, entry version 9.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=Acey_s0275.g1067 {ECO:0000313|EMBL:EYB86679.1};
GN   ORFNames=Y032_0275g1067 {ECO:0000313|EMBL:EYB86679.1};
OS   Ancylostoma ceylanicum.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Strongylida; Ancylostomatoidea; Ancylostomatidae; Ancylostomatinae;
OC   Ancylostoma.
OX   NCBI_TaxID=53326 {ECO:0000313|EMBL:EYB86679.1, ECO:0000313|Proteomes:UP000024635};
RN   [1] {ECO:0000313|Proteomes:UP000024635}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX   PubMed=25730766; DOI=10.1038/ng.3237;
RA   Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA   Aroian R.V.;
RT   "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT   ceylanicum identify infection-specific gene families.";
RL   Nat. Genet. 47:416-422(2015).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EYB86679.1}.
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DR   EMBL; JARK01001611; EYB86679.1; -; Genomic_DNA.
DR   Proteomes; UP000024635; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000024635};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    267    291       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    312    330       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    404    423       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    444    463       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   536 AA;  61287 MW;  D5B5DCE010B4B6DA CRC64;
     MATSEEDAHS HPGMQSDNAP LKIQLRFVAG VIRRERLPAF ERLLWRACRG NVFLRTSEID
     DVLNDTVTGE PVNKTVFIIF FQGDQLKTKV KKICEGFRAT LYPCPDTPQE RREMSIGVMT
     RIEDLKTVLG QTQDHRHRVL VAASKNVRMW LTKVRKIKSI YHTLNLFNID VTHLHHRIVA
     LQKCLIAECW CPLSELDRIK MALKRGTEES GSQVPSILNR METTEAPPTY HKTNKFTRGF
     QNIVDAYGIA TYREINPAPY TMISFPFLFA VMFGDLGHGT IMLLAALFFI LKEKQLEAAR
     IKDEIFQTFF GGRYVIFLMG AFSIYTGLLY NDVFSKSLNI FGSGWTNCYD LQQIARLGYG
     PEKNLMLIPE KAYDDAAGPY PIGVDPVWNL AESNKLNFLN SLKMKLSVIL GITQMTFGVL
     LSYQNYKYFK SDLDIKFMFI PQMIFLACIF IYLCLEIVVK WIWFTAGPQD SIFGYKYPGS
     NCAPSLLIGL INMFMMKTMG TGFVEEDGSQ KFQCYLNNWY PGQVLFSTVV YSYFAA
//
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