ID   A0A016S9V0_9BILA        Unreviewed;       736 AA.
AC   A0A016S9V0;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=Rho-GAP domain-containing protein {ECO:0000259|PROSITE:PS50238};
GN   Name=Acey_s0262.g571 {ECO:0000313|EMBL:EYB87463.1};
GN   Synonyms=Acey-Y34B4A.8 {ECO:0000313|EMBL:EYB87463.1};
GN   ORFNames=Y032_0262g571 {ECO:0000313|EMBL:EYB87463.1};
OS   Ancylostoma ceylanicum.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=53326 {ECO:0000313|EMBL:EYB87463.1, ECO:0000313|Proteomes:UP000024635};
RN   [1] {ECO:0000313|Proteomes:UP000024635}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX   PubMed=25730766; DOI=10.1038/ng.3237;
RA   Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA   Aroian R.V.;
RT   "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT   ceylanicum identify infection-specific gene families.";
RL   Nat. Genet. 47:416-422(2015).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EYB87463.1}.
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DR   EMBL; JARK01001598; EYB87463.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A016S9V0; -.
DR   STRING; 53326.A0A016S9V0; -.
DR   Proteomes; UP000024635; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR004148; BAR_dom.
DR   InterPro; IPR047165; RHG17/44/SH3BP1-like.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   PANTHER; PTHR14130; 3BP-1 RELATED RHOGAP; 1.
DR   PANTHER; PTHR14130:SF14; RHO GTPASE-ACTIVATING PROTEIN 92B; 1.
DR   Pfam; PF03114; BAR; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000024635}.
FT   DOMAIN          252..435
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   REGION          445..532
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          544..649
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          159..193
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        447..483
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        506..532
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        566..585
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        595..609
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        626..646
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   736 AA;  82130 MW;  ACB8F01948D8F2D9 CRC64;
     MEKAKKDVGQ KFRRIKHNLV NSTRKDDDDD LKIVNALEHR NQRVVNAVYT YRKHVSNTVK
     TGLREENVDK RRKKLDEFSL CTDLREISTE LEALHTTCLH KVIQKITQAL QVVVDEKVKH
     DMMIEKRVLD DLVQFQDMEK ALTKSRERLN NAFTDVDIAK KALEKADSTS SNISQLQDTL
     DAAQLKLENQ KDNTITDVYS LAAKEQEIAK VFTALLEEQL EYHRVAMRTL EMVLPEIRRD
     IDNARPRPVF GVDLTEHLRH TQGRVAIVLE KCCSMLRASG FTEKGLFRVN GNNTKIRRMK
     AAFDAGQIDT DERAYYLDPH SVCSVLKSYL RELPDPLLTH RLHNEWVNAA KLEDEAKLQA
     FERCIGELPA CHRHNLTYLI NFLSEMLQHQ DQTAMNCGNL AIVFGPNLLG GDIDGNNAVG
     TKIVETLLKH ASRLFGCPVV NNGSGGGHQP AGRSLTVDTN SPPKPGQSKD RSEYGSISSW
     GTSPRGRPKE RAPPPPYVTP KTGSLIDLSD ECNNTDQTAH TSTTARIDPS LTQSQSLMSA
     DLSESFGMSP TATAESDDSF DEYQDESLPG SMSRSQGDIT AASLTTPQRP PPPTFRNGSE
     SSNNRPLSYN KAVGAEPIPV PRSRTSRSVV MENNSSSSSG SGSIKRPSIL NREDIVGADV
     SNRTPPEFPT PGFSSDQGVC SPVPLWSAPE ITLVLTVFRY HVNDSPICRN YEVKYIATSF
     ITNHSSWNRI WSLYQV
//