ID   A0A016SVE9_9BILA        Unreviewed;       783 AA.
AC   A0A016SVE9;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Pre-rRNA-processing protein TSR1 homolog {ECO:0000256|ARBA:ARBA00040070};
GN   Name=Acey_s0172.g358 {ECO:0000313|EMBL:EYB94382.1};
GN   Synonyms=Acey-tag-151 {ECO:0000313|EMBL:EYB94382.1};
GN   ORFNames=Y032_0172g358 {ECO:0000313|EMBL:EYB94382.1};
OS   Ancylostoma ceylanicum.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=53326 {ECO:0000313|EMBL:EYB94382.1, ECO:0000313|Proteomes:UP000024635};
RN   [1] {ECO:0000313|Proteomes:UP000024635}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX   PubMed=25730766; DOI=10.1038/ng.3237;
RA   Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA   Aroian R.V.;
RT   "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT   ceylanicum identify infection-specific gene families.";
RL   Nat. Genet. 47:416-422(2015).
CC   -!- FUNCTION: Required during maturation of the 40S ribosomal subunit in
CC       the nucleolus. {ECO:0000256|ARBA:ARBA00037087}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000256|ARBA:ARBA00004604}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC       superfamily. Bms1-like GTPase family. TSR1 subfamily.
CC       {ECO:0000256|ARBA:ARBA00038288}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EYB94382.1}.
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DR   EMBL; JARK01001508; EYB94382.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A016SVE9; -.
DR   STRING; 53326.A0A016SVE9; -.
DR   Proteomes; UP000024635; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR012948; AARP2CN.
DR   InterPro; IPR039761; Bms1/Tsr1.
DR   InterPro; IPR007034; BMS1_TSR1_C.
DR   InterPro; IPR030387; G_Bms1/Tsr1_dom.
DR   PANTHER; PTHR12858:SF1; PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG; 1.
DR   PANTHER; PTHR12858; RIBOSOME BIOGENESIS PROTEIN; 1.
DR   Pfam; PF08142; AARP2CN; 1.
DR   Pfam; PF04950; RIBIOP_C; 1.
DR   SMART; SM00785; AARP2CN; 1.
DR   SMART; SM01362; DUF663; 1.
DR   PROSITE; PS51714; G_BMS1; 1.
PE   3: Inferred from homology;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW   Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517}.
FT   DOMAIN          83..243
FT                   /note="Bms1-type G"
FT                   /evidence="ECO:0000259|PROSITE:PS51714"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          333..450
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        353..373
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        389..450
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   783 AA;  88797 MW;  0C3359FA0BB45CBC CRC64;
     MSTGHQPGLF KRPAKAHKTF KGKRSKGQID AENRGRVGVS SAIRARKRLL SKEERHQQAV
     HIRANKRRAA FEQRRGLDGG ISAPTLITVI AFDGSQAPAA FVEQIAGCDE TIVRTLGHNV
     DYLGIPRFKS RVGFISADLS KLDYVLDSVK VSDVVCFLWP VQGQLSDEEH LLLTALKAHG
     LPSFVNVVPH LGSIPVGKKR EDAKKHVQSL VAEVSLNTNK LFCCDTDPER IILLRHFIDM
     KKNKMLLQKR RPHILVEKLD VVDDNDGICS VLASGYLRGP TWNVNHLVHI QGWGDFQIGR
     ILAHVDPHPL KQRENTGGDA VIEPKVLVVA DESRRESLQS EIVPDPLDAE QTWPDEYDVK
     EDAQLKKTSE KRSVPKGTSS YQAAWIVDGE EEDSVDGSEE ESEEDEDEEE NEAGMEVEAA
     DENDTEDQEN NEDMEDYMSE SGDDGGDEAD DLDEVEKYRR ERENAQFPDE IDTPIGDLAR
     IRFQKYRGLK SFRTSPWDPK ENLPSDYARI FQFQNYKKTR KTVLSTIGEY DSTSCVFSGQ
     YVTLQIDRVP VTFAQQWNVN APMVLYQLLP HEQRMSVLNF VIRKHPSCRV PIMNKQKLIF
     NVGFRKFEAC PIFSQHTNGD KFKLERFLPT NSSCVATVFA PIIFPPASVL VFREGKAGKE
     ELVATGSILD INPDRIVLKR IVLSGHPFKI NKRSVVCRYM FFNREDIEWF KPVELYTPSG
     RRGHIKEPLG THGHMKCRFD QQLNAGDSVM MSLYKRVFPK WTYNPRVKCA NTGTVQESEE
     MDV
//