ID A0A016SYG1_9BILA Unreviewed; 1103 AA.
AC A0A016SYG1;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=RhoGAP domain protein {ECO:0008006|Google:ProtNLM};
GN Name=Acey_s0160.g3321 {ECO:0000313|EMBL:EYB95369.1};
GN Synonyms=Acey-gei-1 {ECO:0000313|EMBL:EYB95369.1};
GN ORFNames=Y032_0160g3321 {ECO:0000313|EMBL:EYB95369.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYB95369.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYB95369.1}.
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DR EMBL; JARK01001496; EYB95369.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016SYG1; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.287.2070; -; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR023393; START-like_dom_sf.
DR InterPro; IPR002913; START_lipid-bd_dom.
DR PANTHER; PTHR12659:SF7; CROSSVEINLESS C, ISOFORM C; 1.
DR PANTHER; PTHR12659; RHO-TYPE GTPASE ACTIVATING PROTEIN; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF01852; START; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00234; START; 1.
DR SUPFAM; SSF55961; Bet v1-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50848; START; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000024635}.
FT DOMAIN 652..865
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 898..1099
FT /note="START"
FT /evidence="ECO:0000259|PROSITE:PS50848"
FT REGION 127..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 262..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 436..515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..173
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..188
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 189..224
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 281..308
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 350..368
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 444..469
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 479..515
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1103 AA; 124242 MW; 4808DF612854B239 CRC64;
MQLIDSVLIS EEDALECCHW LRQAGFPQYA KQYQEGRFPI DIRSVQSDHE FLGPDSLRAL
YRRLNTLNRC AIMRIDQVVL RRRNDDYSYG MYDGFDDDDS IALSGNWRYQ RHSHTWSRVG
NEQMYGVPGR TVCPKPNWDS YRDQLDPRSR YDVREMRDPY AGKRSDRQLE RYTESPDCNG
NSASNKLQRS HSERIKERAR AIMKKMDLRS SSRRRKDSRH RDPNAMVIGD PVLVSYDSAS
PETMRMMPRP NNLDARSARV TNATTANVAS DRHSRSKSAR RQGMVVLSPS SPDSSDDSFL
SSTHRRPTGS SAHARRDRSV PPQLVDTTEY DYAPQDRLRR ERMPPYETYL YPTSPNSLTR
TTAPPRPSRR ALQQAVSAAA AAGGYDASSG GSPYYGSGGY SSSPAYSSPY STRSYQSPPV
VARNLVIQPD GYFMHDVSPD TSLSRLRPPR SESPSTSSGV PQLRVDTHAN KSESSLDNTD
EEQSSGTTTM NHNRRDSGVG SSLSRSPSGP SSQRLRQSIL PYSTNSFSFL LNANHVGSLQ
SKRRAADRNL MSSSILSSCS SDDAFFTDVQ LARCVDSLSV LELARLNKLA YLRVTAILEK
HMGPGSTVKI GDVSPTQNGA VKNWTVQKLF KKIKMDGKTG REIEVANQVF GQPLTVIYRR
SGLCLPRTIL EVLRYLRQMA PDTVGIFRKN GVKSRILEVR ALCDRDADAD VFVDENRLDP
GQVHDVADML KQYLRELPEP LMTARLSETF ANIFIHVPEN ERLLALQYAI LLLPDENREA
LQTLLLFLSD ISKHSDNNSM PAQNLAVCFT PSLFQLSASR LDKVTPTRRH KTIGAAGMPT
EREMRETRAA QQCLTYLIQH CRSVFVAAET GPEDRIQADS DAPLLKELGL NGPRAYLIDR
VLDLVKEHSD RWKSWIVEGI HEDVEISCKV PNDCHPLKLF RVWVDVAAPP KQVMNRIMRE
RSVWDTSVVN WRTIDVLHAP DTDLHQYVLN DTVGHPTRDC FVARFHRADL SEIRGACAIA
ERSVQCSETQ LLGGTSAAVL DSRFLIEPKA GHSRVTYISR IDLRGRGPAW YNKVYGNIVA
RQMIRLRDSF QSSSENIGPE TKV
//
